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2002 1
2005 1
2006 1
2007 3
2009 1
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2013 1
2014 5
2015 7
2016 3
2017 2
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2019 6
2020 9
2021 5
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2023 5
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56 results

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Page 1
Mechanisms and potential applications of COPS6 in pan-cancer therapy.
Wu T, Ji MR, Luo LX. Wu T, et al. World J Clin Oncol. 2024 Mar 24;15(3):367-370. doi: 10.5306/wjco.v15.i3.367. World J Clin Oncol. 2024. PMID: 38576589 Free PMC article.
The COP9 signalosome subunit 6 (COPS6) is abnormally overexpressed in many malignancies, yet its precise role in carcinogenesis is unknown. ...This suggests that COPS6 may be a potential target for cancer treatment. Overall, this research provides insight into CO …
The COP9 signalosome subunit 6 (COPS6) is abnormally overexpressed in many malignancies, yet its precise role in carcinogenesis is un …
Proteomics and transcriptomics explore the effect of mixture of herbal extract on diabetic wound healing process.
Liu Y, Zhang X, Yang L, Zhou S, Li Y, Shen Y, Lu S, Zhou J, Liu Y. Liu Y, et al. Phytomedicine. 2023 Jul 25;116:154892. doi: 10.1016/j.phymed.2023.154892. Epub 2023 May 24. Phytomedicine. 2023. PMID: 37267693
Proteomics results showed that the following proteins were important in wounds treated with MHE: Rack1, LOC100362366, Cops2, Cops6, Eif4e, Eif3c, Rpl12, Srp54, Rpl13 and Lsm7. Autophagy, PI3-Akt and mTOR signaling pathways were enriched after treatment with MHE compared to …
Proteomics results showed that the following proteins were important in wounds treated with MHE: Rack1, LOC100362366, Cops2, Cops6, E …
COPS6 promotes tumor progression and reduces CD8(+) T cell infiltration by repressing IL-6 production to facilitate tumor immune evasion in breast cancer.
Du WQ, Zhu ZM, Jiang X, Kang MJ, Pei DS. Du WQ, et al. Acta Pharmacol Sin. 2023 Sep;44(9):1890-1905. doi: 10.1038/s41401-023-01085-8. Epub 2023 Apr 24. Acta Pharmacol Sin. 2023. PMID: 37095198
Flow cytometry was conducted to identify the role of COPS6 on tumor-infiltrating CD8(+) T cells. By analyzing the TCGA and GTEx cohort, we found that COPS6 expression was significantly up-regulated in a variety of cancers. In human osteosarcoma cell line U2OS and no …
Flow cytometry was conducted to identify the role of COPS6 on tumor-infiltrating CD8(+) T cells. By analyzing the TCGA and GTEx cohor …
CSN6-COP1 axis in cancer.
Choi HH, Lee MH. Choi HH, et al. Aging (Albany NY). 2015 Jul;7(7):461-2. doi: 10.18632/aging.100778. Aging (Albany NY). 2015. PMID: 26186957 Free PMC article. No abstract available.
Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes.
Lewno MT, Cui T, Wang X. Lewno MT, et al. Front Physiol. 2021 Jun 28;12:690423. doi: 10.3389/fphys.2021.690423. eCollection 2021. Front Physiol. 2021. PMID: 34262479 Free PMC article.
As revealed by cardiomyocyte-restricted knockout of Cops8 (Cops8-cko) in mice, perturbation of Cullin deneddylation in cardiomyocytes impairs not only the functioning of the ubiquitin-proteasome system (UPS) but also the autophagic-lysosomal pathway (ALP). Similar cardiac abnorma …
As revealed by cardiomyocyte-restricted knockout of Cops8 (Cops8-cko) in mice, perturbation of Cullin deneddylation in cardiomyocytes impair …
Computational exploration of the significance of COPS6 in cancer: Functional and clinical relevance across tumor types.
Wang SL, Zhuo GZ, Wang LP, Jiang XH, Liu GH, Pan YB, Li YR. Wang SL, et al. World J Clin Oncol. 2023 Nov 24;14(11):479-503. doi: 10.5306/wjco.v14.i11.479. World J Clin Oncol. 2023. PMID: 38059183 Free PMC article.
The correlation between COPS6 expression level and macrophage infiltration was closely related to macrophage type. ...CONCLUSION: In conclusion, this study systematically explored the significance of COPS6 across different tumor types, providing a solid foundation f …
The correlation between COPS6 expression level and macrophage infiltration was closely related to macrophage type. ...CONCLUSION: In …
The deubiquitylating enzyme Cops6 regulates different developmental processes during early zebrafish embryogenesis.
Tse WK, You MS, Ho SH, Jiang YJ. Tse WK, et al. Int J Dev Biol. 2011;55(1):19-24. doi: 10.1387/ijdb.103089wt. Int J Dev Biol. 2011. PMID: 21425078 Free article.
Zebrafish cops6 encodes a putative deubiquitylating enzyme (DUB) that belongs to the JAMM family. ...Here, we report our findings regarding the general function of the cops6 gene, as a continuation of our previous studies involving DUB knockdown screening. ...
Zebrafish cops6 encodes a putative deubiquitylating enzyme (DUB) that belongs to the JAMM family. ...Here, we report our findings reg …
Analysis of expression profiles and prognostic value of COP9 signalosome subunits for patients with head and neck squamous cell carcinoma.
Zhou H, Sun W, Zou J. Zhou H, et al. Oncol Lett. 2021 Nov;22(5):803. doi: 10.3892/ol.2021.13064. Epub 2021 Sep 23. Oncol Lett. 2021. PMID: 34630710 Free PMC article.
High mRNA expression level of COPS2, COPS5, COPS6, COPS7A, COPS7B, COPS8 and COPS9 had prognostic significance of patients with HNSCC. Knockdown of COPS5 and COPS6 inhibited cell growth and migration of the CAL27 and SCC25 cell lines. ...
High mRNA expression level of COPS2, COPS5, COPS6, COPS7A, COPS7B, COPS8 and COPS9 had prognostic significance of patients with HNSCC …
56 results