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CRISPLD1 promotes gastric cancer progression by regulating the Ca(2+)/PI3K-AKT signaling pathway.
Hu L, Shi J, Zhu Z, Lu X, Jiang H, Yu H, Liu H, Chen W. Hu L, et al. Heliyon. 2024 Mar 7;10(5):e27569. doi: 10.1016/j.heliyon.2024.e27569. eCollection 2024 Mar 15. Heliyon. 2024. PMID: 38486747 Free PMC article.
Gastric cancer (GC) is a malignant tumor with poor prognosis. Studies have shown that cysteine-rich secretory protein LCCL domain containing 1 (CRISPLD1) is associated with tumor progression. ...The present study aimed to determine the pathogenic mechanism of CRI …
Gastric cancer (GC) is a malignant tumor with poor prognosis. Studies have shown that cysteine-rich secretory protein LCCL domain con …
The functions of CAP superfamily proteins in mammalian fertility and disease.
Gaikwad AS, Hu J, Chapple DG, O'Bryan MK. Gaikwad AS, et al. Hum Reprod Update. 2020 Sep 1;26(5):689-723. doi: 10.1093/humupd/dmaa016. Hum Reprod Update. 2020. PMID: 32378701 Review.
Although many CAP superfamily proteins remain poorly characterized, over the past decade evidence has accumulated, which provides insights into the functional roles of these proteins in various processes, including fertilization, immune defence and subversion, pathogen virulence, …
Although many CAP superfamily proteins remain poorly characterized, over the past decade evidence has accumulated, which provides insights i …
The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense.
Gibbs GM, Roelants K, O'Bryan MK. Gibbs GM, et al. Endocr Rev. 2008 Dec;29(7):865-97. doi: 10.1210/er.2008-0032. Epub 2008 Sep 29. Endocr Rev. 2008. PMID: 18824526 Review.
Within humans and mice, there are 31 and 33 individual family members, respectively, and although many are poorly characterized, the majority show a notable expression bias to the reproductive tract and immune tissues or are deregulated in cancers. CAP superfamily proteins …
Within humans and mice, there are 31 and 33 individual family members, respectively, and although many are poorly characterized, the majorit …
Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line.
Li W, Wang S, Qiu C, Liu Z, Zhou Q, Kong D, Ma X, Jiang J. Li W, et al. J Transl Med. 2019 Feb 27;17(1):58. doi: 10.1186/s12967-019-1814-6. J Transl Med. 2019. PMID: 30813939 Free PMC article.
The aim of this study was to elucidate the molecular mechanisms of progesterone resistance and to identify the key genes and pathways mediating progesterone resistance in endometrial cancer using bioinformatics analysis. METHODS: We developed a stable MPA (medroxyprogester …
The aim of this study was to elucidate the molecular mechanisms of progesterone resistance and to identify the key genes and pathways mediat …
Searching for a signature involving 10 genes to predict the survival of patients with acute myelocytic leukemia through a combined multi-omics analysis.
Zhuang H, Chen Y, Sheng X, Hong L, Gao R, Zhuang X. Zhuang H, et al. PeerJ. 2020 Jun 25;8:e9437. doi: 10.7717/peerj.9437. eCollection 2020. PeerJ. 2020. PMID: 32617195 Free PMC article.
METHODS: First of all, the copy number variation (CNV), mutation, RNA-Seq, and single nucleotide polymorphism (SNP) data, as well as those clinical follow-up data, were obtained based on The Cancer Genome Atlas (TCGA) database. Thereafter, all samples (n = 229) were random …
METHODS: First of all, the copy number variation (CNV), mutation, RNA-Seq, and single nucleotide polymorphism (SNP) data, as well as those c …
Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex-Associated Renal Cell Carcinoma.
Park JH, Lee C, Chang MS, Kim K, Choi S, Lee H, Lee HS, Moon KC. Park JH, et al. Transl Oncol. 2018 Aug;11(4):962-970. doi: 10.1016/j.tranon.2018.05.010. Epub 2018 Jun 18. Transl Oncol. 2018. PMID: 29925043 Free PMC article.
The mTOR pathway activation and the germline mutations of TSC2 were identified in both TSC-RCC cases. The WES revealed several cancer gene alterations. In Case 1, genetic alterations of CHD8, CRISPLD1, EPB41L4A, GNA11, NOTCH3, PBRM1, PTPRU, RGS12, SETBP1, SMARCA4, S …
The mTOR pathway activation and the germline mutations of TSC2 were identified in both TSC-RCC cases. The WES revealed several cancer …
MicroRNA-374a, -4680, and -133b suppress cell proliferation through the regulation of genes associated with human cleft palate in cultured human palate cells.
Suzuki A, Li A, Gajera M, Abdallah N, Zhang M, Zhao Z, Iwata J. Suzuki A, et al. BMC Med Genomics. 2019 Jul 1;12(1):93. doi: 10.1186/s12920-019-0546-z. BMC Med Genomics. 2019. PMID: 31262291 Free PMC article.
We found that several downstream target CP genes predicted by the bioinformatics analyses were significantly downregulated through induction of these miRNAs (FGFR1, GCH1, PAX7, SMC2, and SUMO1 by miR-133b; ARNT, BMP2, CRISPLD1, FGFR2, JARID2, MSX1, NOG, RHPN2, RUNX2, WNT5A …
We found that several downstream target CP genes predicted by the bioinformatics analyses were significantly downregulated through induction …