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55 results

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Page 1
CSDE1 promotes miR-451 biogenesis.
Kakumani PK, Ko Y, Ramakrishna S, Christopher G, Dodgson M, Shrinet J, Harvey LM, Shin C, Simard MJ. Kakumani PK, et al. Nucleic Acids Res. 2023 Sep 22;51(17):9385-9396. doi: 10.1093/nar/gkad619. Nucleic Acids Res. 2023. PMID: 37493604 Free PMC article.
CSDE1 binds miR-451 and regulates AGO2 processing of pre-miR-451 through its N-terminal domains. ...Together, our results demonstrate that CSDE1 promotes biogenesis of miR-451 in erythroid progenitors....
CSDE1 binds miR-451 and regulates AGO2 processing of pre-miR-451 through its N-terminal domains. ...Together, our results demonstrate …
Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells.
Lv J, Zhou Y, Zhou N, Wang Z, Chen J, Chen H, Wang D, Zhou L, Wei K, Zhang H, Tang K, Ma J, Liu Y, Wan Y, Zhang Y, Zhang H, Huang B. Lv J, et al. Sci Transl Med. 2023 Feb;15(681):eabq6024. doi: 10.1126/scitranslmed.abq6024. Epub 2023 Feb 1. Sci Transl Med. 2023. PMID: 36724242
Thus, owing to the differential epigenetic modification and subsequent differential expression of CSDE1, nascent tumorigenic cells may exhibit either a high or low immunogenicity. This identified SMYD3-CSDE1 pathway represents a potential prognostic marker for ca …
Thus, owing to the differential epigenetic modification and subsequent differential expression of CSDE1, nascent tumorigenic cells ma …
UNR/CSDE1 Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer through Regulation of c-MYC and Epithelial-to-Mesenchymal Transition.
Martinez-Useros J, Garcia-Carbonero N, Li W, Fernandez-Aceñero MJ, Cristobal I, Rincon R, Rodriguez-Remirez M, Borrero-Palacios A, Garcia-Foncillas J. Martinez-Useros J, et al. J Clin Med. 2019 Apr 25;8(4):560. doi: 10.3390/jcm8040560. J Clin Med. 2019. PMID: 31027221 Free PMC article.
In cancer, CSDE1 has been shown to regulate c-Fos, c-Myc, Pten, Rac1, or Vimentin. UNR/CSDE1 has been studied in breast, melanoma, pancreatic and prostate cancer. ...
In cancer, CSDE1 has been shown to regulate c-Fos, c-Myc, Pten, Rac1, or Vimentin. UNR/CSDE1 has been studied in breast …
Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.
Fishbein L, Leshchiner I, Walter V, Danilova L, Robertson AG, Johnson AR, Lichtenberg TM, Murray BA, Ghayee HK, Else T, Ling S, Jefferys SR, de Cubas AA, Wenz B, Korpershoek E, Amelio AL, Makowski L, Rathmell WK, Gimenez-Roqueplo AP, Giordano TJ, Asa SL, Tischler AS; Cancer Genome Atlas Research Network; Pacak K, Nathanson KL, Wilkerson MD. Fishbein L, et al. Cancer Cell. 2017 Feb 13;31(2):181-193. doi: 10.1016/j.ccell.2017.01.001. Epub 2017 Feb 2. Cancer Cell. 2017. PMID: 28162975 Free PMC article.
Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). ...Integrated analysis classified PCCs/PGLs into four molecularly defined g …
Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gen …
Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer.
Kim Y, Ko JY, Lee SB, Oh S, Park JW, Kang HG, Kim DH, Chung D, Lim S, Kong H, Kim J, Yoo KH, Han W, Chun KH, Park JH. Kim Y, et al. Oncogene. 2022 May;41(22):3151-3161. doi: 10.1038/s41388-022-02326-6. Epub 2022 Apr 30. Oncogene. 2022. PMID: 35490208 Free PMC article.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer; however, specific prognostic biomarkers have not yet been developed. ...Mechanistically, CSDE1, phosphorylated C-terminal domain (p-CTD) of RNA polymerase II (RNAPII), and C …
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer; however, specific prognostic biomarkers …
The role of CSDE1 in translational reprogramming and human diseases.
Guo AX, Cui JJ, Wang LY, Yin JY. Guo AX, et al. Cell Commun Signal. 2020 Jan 27;18(1):14. doi: 10.1186/s12964-019-0496-2. Cell Commun Signal. 2020. PMID: 31987048 Free PMC article. Review.
CSDE1 connects with different RNAs and their regulators for different purposes. ...Meanwhile, a number of recent studies have found important roles for CSDE1 in human diseases. This model will help us to understand the role of CSDE1 in translational reprogram …
CSDE1 connects with different RNAs and their regulators for different purposes. ...Meanwhile, a number of recent studies have found i …
CSDE1: a versatile regulator of gene expression in cancer.
Ciocia A, Mestre-Farràs N, Vicent-Nacht I, Guitart T, Gebauer F. Ciocia A, et al. NAR Cancer. 2024 Apr 10;6(2):zcae014. doi: 10.1093/narcan/zcae014. eCollection 2024 Jun. NAR Cancer. 2024. PMID: 38600987 Free PMC article.
This review focuses on one such modulator, the protein CSDE1, and its pivotal role in regulating cancer hallmarks. We discuss context-specific functions of CSDE1 in tumor development, its mechanisms of action, and highlight features that support its role as a …
This review focuses on one such modulator, the protein CSDE1, and its pivotal role in regulating cancer hallmarks. We discuss …
CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
Kakumani PK, Guitart T, Houle F, Harvey LM, Goyer B, Germain L, Gebauer F, Simard MJ. Kakumani PK, et al. Oncogene. 2021 May;40(18):3231-3244. doi: 10.1038/s41388-021-01767-9. Epub 2021 Apr 8. Oncogene. 2021. PMID: 33833398
We find an association of CSDE1 with AGO2, the essential component of miRISC, which is facilitated by target mRNAs and depends on the first cold shock domain of CSDE1. Both CSDE1 and AGO2 bind to 3' UTR of PMEPA1. CSDE1 counters AGO2 binding, leading t …
We find an association of CSDE1 with AGO2, the essential component of miRISC, which is facilitated by target mRNAs and depends on the …
LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1.
Xie P, Guo Y. Xie P, et al. Biosci Rep. 2020 Oct 30;40(10):BSR20190701. doi: 10.1042/BSR20190701. Biosci Rep. 2020. PMID: 32808651 Free PMC article.
Lung cancer (LC) is characterized by high morbidity and mortality. Numerous long noncoding RNAs (lncRNAs) have been reported to be involved in the initiation and progression of human cancers, including LC. ...Moreover, we found that LINC00205 recruited FUS to mainta …
Lung cancer (LC) is characterized by high morbidity and mortality. Numerous long noncoding RNAs (lncRNAs) have been reported to be in …
Cold Shock Domain Containing E1 (CSDE1) Protein is Overexpressed and Can be Targeted to Inhibit Invasiveness in Pancreatic Cancer Cells.
Liu H, Li X, Dun MD, Faulkner S, Jiang CC, Hondermarck H. Liu H, et al. Proteomics. 2020 May;20(10):e1900331. doi: 10.1002/pmic.201900331. Epub 2020 Apr 24. Proteomics. 2020. PMID: 32170829
The expression of CSDE1 in pancreatic cancer cells is confirmed by Western blotting and immunohistochemistry of human pancreatic tumors. ...Together, this study reveals that CSDE1 is overexpressed in pancreatic cancer and is a potential therapeutic tar …
The expression of CSDE1 in pancreatic cancer cells is confirmed by Western blotting and immunohistochemistry of human pancreat …
55 results