Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 4
1989 6
1990 11
1991 19
1992 18
1993 17
1994 14
1995 11
1996 9
1997 12
1998 10
1999 16
2000 6
2001 7
2002 12
2003 6
2004 15
2005 15
2006 20
2007 20
2008 33
2009 44
2010 47
2011 50
2012 57
2013 64
2014 98
2015 91
2016 117
2017 115
2018 168
2019 209
2020 233
2021 260
2022 261
2023 296
2024 107

Text availability

Article attribute

Article type

Publication date

Search Results

2,227 results

Results by year

Filters applied: . Clear all
Page 1
CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.
Wen J, Wang S, Guo R, Liu D. Wen J, et al. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114884. doi: 10.1016/j.ejmech.2022.114884. Epub 2022 Oct 29. Eur J Med Chem. 2023. PMID: 36335744 Review.
Mutations of CSF1R have been implicated in neurodegeneration, skeletal anomalies, and cancers. ...Herein, we've comprehensively reviewed the latest progression of CSF1R inhibitors under clinical and preclinical studies. Key findings of CSF1R targeted therapie …
Mutations of CSF1R have been implicated in neurodegeneration, skeletal anomalies, and cancers. ...Herein, we've comprehensively revie …
CSF1R-related leukoencephalopathy: A major player in primary microgliopathies.
Konno T, Kasanuki K, Ikeuchi T, Dickson DW, Wszolek ZK. Konno T, et al. Neurology. 2018 Dec 11;91(24):1092-1104. doi: 10.1212/WNL.0000000000006642. Epub 2018 Nov 14. Neurology. 2018. PMID: 30429277 Free PMC article. Review.
These mice develop clinical, radiologic, and pathologic phenotypes consistent with those of human patients with CSF1R mutations. In vitro, perturbation of CSF1R signaling is shown in cultured cells expressing mutant CSF1R. ...Given that CSF1R mainly ex …
These mice develop clinical, radiologic, and pathologic phenotypes consistent with those of human patients with CSF1R mutations. In v …
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy.
Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, Rüttinger D. Cannarile MA, et al. J Immunother Cancer. 2017 Jul 18;5(1):53. doi: 10.1186/s40425-017-0257-y. J Immunother Cancer. 2017. PMID: 28716061 Free PMC article. Review.
We review the currently available clinical safety and efficacy data with CSF1/CSF1R-targeting agents and provide a comprehensive overview of ongoing clinical studies. Furthermore, we discuss the local tissue macrophage and tumor-type specificities and their potential impac …
We review the currently available clinical safety and efficacy data with CSF1/CSF1R-targeting agents and provide a comprehensive over …
CSF1R-Related Disorder.
Dulski J, Sundal C, Wszolek ZK. Dulski J, et al. 2012 Aug 30 [updated 2024 Apr 4]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2012 Aug 30 [updated 2024 Apr 4]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 22934315 Free Books & Documents. Review.
Death most commonly results from pneumonia or other infections. About 500 individuals with CSF1R-related disorder have been reported to date. DIAGNOSIS/TESTING: The diagnosis of CSF1R-related disorder is established in a proband with suggestive findings and a hetero …
Death most commonly results from pneumonia or other infections. About 500 individuals with CSF1R-related disorder have been reported …
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Rojo R, et al. Nat Commun. 2019 Jul 19;10(1):3215. doi: 10.1038/s41467-019-11053-8. Nat Commun. 2019. PMID: 31324781 Free PMC article.
The proliferation, differentiation and survival of mononuclear phagocytes depend on signals from the receptor for macrophage colony-stimulating factor, CSF1R. The mammalian Csf1r locus contains a highly conserved super-enhancer, the fms-intronic regulatory element ( …
The proliferation, differentiation and survival of mononuclear phagocytes depend on signals from the receptor for macrophage colony-stimulat …
Small-Molecule CSF1R Inhibitors as Anticancer Agents.
Xun Q, Wang Z, Hu X, Ding K, Lu X. Xun Q, et al. Curr Med Chem. 2020;27(23):3944-3966. doi: 10.2174/1573394715666190618121649. Curr Med Chem. 2020. PMID: 31215373 Review.
Consequently, CSF1R kinase has been a target of great interest in cancer treatment and significant research efforts have focused on the development of smallmolecule CSF1R inhibitors. In this review, we highlight current progress on the development of these small mol …
Consequently, CSF1R kinase has been a target of great interest in cancer treatment and significant research efforts have focused on t …
CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple.
Hume DA, Batoon L, Sehgal A, Keshvari S, Irvine KM. Hume DA, et al. Curr Osteoporos Rep. 2022 Dec;20(6):516-531. doi: 10.1007/s11914-022-00757-4. Epub 2022 Oct 5. Curr Osteoporos Rep. 2022. PMID: 36197652 Free PMC article. Review.
PURPOSE OF REVIEW: The purpose of the review is to summarize the expression and function of CSF1R and its ligands in bone homeostasis and constraints on therapeutic targeting of this axis. ...Loss-of-function mutations in CSF1 or CSF1R lead to loss of OCL and macrop …
PURPOSE OF REVIEW: The purpose of the review is to summarize the expression and function of CSF1R and its ligands in bone homeostasis …
CSF1R-related leukoencephalopathy.
Shetty D, Desai A, Gupta V, Agarwal A. Shetty D, et al. J Clin Neurosci. 2023 Jul;113:60-61. doi: 10.1016/j.jocn.2023.05.008. Epub 2023 May 18. J Clin Neurosci. 2023. PMID: 37209513 No abstract available.
Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice.
Wang Y, Wernersbach I, Strehle J, Li S, Appel D, Klein M, Ritter K, Hummel R, Tegeder I, Schäfer MKE. Wang Y, et al. Brain Behav Immun. 2022 Nov;106:49-66. doi: 10.1016/j.bbi.2022.07.164. Epub 2022 Aug 3. Brain Behav Immun. 2022. PMID: 35933030 Free article.
Microglia/macrophage (M/M) depletion and repopulation after treatment with colony stimulating factor 1 receptor (CSF1R) inhibitors reduces neurodegeneration. The present study investigates short- and long-term consequences after CSF1R inhibition during the early pha …
Microglia/macrophage (M/M) depletion and repopulation after treatment with colony stimulating factor 1 receptor (CSF1R) inhibitors re …
Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits.
Henry RJ, Ritzel RM, Barrett JP, Doran SJ, Jiao Y, Leach JB, Szeto GL, Wu J, Stoica BA, Faden AI, Loane DJ. Henry RJ, et al. J Neurosci. 2020 Apr 1;40(14):2960-2974. doi: 10.1523/JNEUROSCI.2402-19.2020. Epub 2020 Feb 24. J Neurosci. 2020. PMID: 32094203 Free PMC article.
Microglia, the primary innate immune cells in brain, are dependent on colony stimulating factor 1 receptor (CSF1R) signaling for their survival. In this preclinical study, we examined the effects of delayed depletion of chronically activated microglia on functional recover …
Microglia, the primary innate immune cells in brain, are dependent on colony stimulating factor 1 receptor (CSF1R) signaling for thei …
2,227 results