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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 1
2006 1
2007 3
2008 4
2009 8
2010 2
2011 6
2012 2
2013 15
2014 23
2015 27
2016 17
2017 21
2018 26
2019 27
2020 31
2021 25
2022 31
2023 31
2024 14

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272 results

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Page 1
Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.
Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW. Maxson JE, et al. N Engl J Med. 2013 May 9;368(19):1781-90. doi: 10.1056/NEJMoa1214514. N Engl J Med. 2013. PMID: 23656643 Free PMC article.
BACKGROUND: The molecular causes of many hematologic cancers remain unclear. Among these cancers are chronic neutrophilic leukemia (CNL) and atypical (BCR-ABL1-negative) chronic myeloid leukemia (CML), both of which are diagnosed on the basis of neoplastic expansion …
BACKGROUND: The molecular causes of many hematologic cancers remain unclear. Among these cancers are chronic neutrophilic leuk …
The MPL mutation.
Guglielmelli P, Calabresi L. Guglielmelli P, et al. Int Rev Cell Mol Biol. 2021;365:163-178. doi: 10.1016/bs.ircmb.2021.09.003. Epub 2021 Oct 2. Int Rev Cell Mol Biol. 2021. PMID: 34756243 Review.
Myeloproliferative neoplasms (MPN) patients share driver mutations in JAK2, MPL or CALR genes leading to the activation of the thrombopoietin receptor (TPOR) and downstream signaling pathways. JAK2 mutation drives all the three major entities of MPN (Polycythemia Vera, Ess …
Myeloproliferative neoplasms (MPN) patients share driver mutations in JAK2, MPL or CALR genes leading to the activation of the thromb …
Severe congenital neutropenias.
Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K. Skokowa J, et al. Nat Rev Dis Primers. 2017 Jun 8;3:17032. doi: 10.1038/nrdp.2017.32. Nat Rev Dis Primers. 2017. PMID: 28593997 Free PMC article. Review.
Molecular events in the malignant progression include acquired mutations in CSF3R (encoding G-CSF receptor) and subsequently in other leukaemia-associated genes (such as RUNX1) in a majority of patients. ...
Molecular events in the malignant progression include acquired mutations in CSF3R (encoding G-CSF receptor) and subsequently in other …
CSF3R and SETBP1 getting high on LSD1.
Zhao H, Deininger MW. Zhao H, et al. Blood. 2022 Aug 11;140(6):529-530. doi: 10.1182/blood.2022016740. Blood. 2022. PMID: 35951346 Free PMC article. No abstract available.
Oral Cancer Cells Release Vesicles that Cause Pain.
Dubeykovskaya ZA, Tu NH, Garcia PDR, Schmidt BL, Albertson DG. Dubeykovskaya ZA, et al. Adv Biol (Weinh). 2022 Sep;6(9):e2200073. doi: 10.1002/adbi.202200073. Epub 2022 Jul 8. Adv Biol (Weinh). 2022. PMID: 35802912 Free PMC article.
Oral cancer pain is attributed to the release from cancers of mediators that sensitize and activate sensory neurons. ...These studies confirm the recent discovery of the role of cancer EVs in pain and add to the repertoire of algesic and analgesic cancer …
Oral cancer pain is attributed to the release from cancers of mediators that sensitize and activate sensory neurons. ...These …
Differential Implications of CSF3R Mutations in t(8;21) and CEBPA Double Mutated Acute Myeloid Leukemia.
Wang B, Wen L, Wang Z, Chen S, Qiu H. Wang B, et al. Clin Lymphoma Myeloma Leuk. 2022 Jun;22(6):393-404. doi: 10.1016/j.clml.2021.11.013. Epub 2021 Dec 2. Clin Lymphoma Myeloma Leuk. 2022. PMID: 34975010 Free article.
The purpose of this study was to analyze the CSF3R mutations (CSF3R(mut)) in AML with recurrent genetic abnormalities for potential synergistic pathomechanism. ...Cases with CSF3R(mut) had a lower WBC count versus those with CSF3R wild-type (CSF3R …
The purpose of this study was to analyze the CSF3R mutations (CSF3R(mut)) in AML with recurrent genetic abnormalities for pote …
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, Magrini E, Gianni F, Kunderfranco P, Polentarutti N, Pasqualini F, Di Marco S, Supino D, Peano C, Cananzi F, Colombo P, Pilotti S, Alomar SY, Bonavita E, Galdiero MR, Garlanda C, Mantovani A, Jaillon S. Ponzetta A, et al. Cell. 2019 Jul 11;178(2):346-360.e24. doi: 10.1016/j.cell.2019.05.047. Epub 2019 Jun 27. Cell. 2019. PMID: 31257026 Free PMC article.
Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene- …
Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a gen …
Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis.
Yip RKH, Rimes JS, Capaldo BD, Vaillant F, Mouchemore KA, Pal B, Chen Y, Surgenor E, Murphy AJ, Anderson RL, Smyth GK, Lindeman GJ, Hawkins ED, Visvader JE. Yip RKH, et al. Nat Commun. 2021 Nov 26;12(1):6920. doi: 10.1038/s41467-021-26556-6. Nat Commun. 2021. PMID: 34836954 Free PMC article.
Bone marrow is a preferred metastatic site for multiple solid tumours and is associated with poor prognosis and significant morbidity. Accumulating evidence indicates that cancer cells colonise specialised niches within the bone marrow to support their long-term propagatio …
Bone marrow is a preferred metastatic site for multiple solid tumours and is associated with poor prognosis and significant morbidity. Accum …
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW. Dao KT, et al. J Clin Oncol. 2020 Apr 1;38(10):1006-1018. doi: 10.1200/JCO.19.00895. Epub 2019 Dec 27. J Clin Oncol. 2020. PMID: 31880950 Free PMC article. Clinical Trial.
In the larger cohort of 44 patients, 35% had a response (11 PR [9 CNL and 2 aCML] and 4 CR [CNL]), and 50% had oncogenic CSF3R mutations. The mean absolute allele burden reduction of CSF3R-T618I after 6 cycles was greatest in the CR group, compared with the PR and n …
In the larger cohort of 44 patients, 35% had a response (11 PR [9 CNL and 2 aCML] and 4 CR [CNL]), and 50% had oncogenic CSF3R mutati …
Identification of CSF3R Mutations in B-Lineage Acute Lymphoblastic Leukemia Using Comprehensive Cancer Panel and Next-Generation Sequencing.
Rashid M, Alasiri A, Al Balwi MA, Alkhaldi A, Alsuhaibani A, Alsultan A, Alharbi T, Alomair L, Almuzzaini B. Rashid M, et al. Genes (Basel). 2021 Aug 27;12(9):1326. doi: 10.3390/genes12091326. Genes (Basel). 2021. PMID: 34573308 Free PMC article.
Here, we use the advantage of Next-generation sequencing (NGS) technology to study the mutation landscape of 12 patients with B-ALL using Comprehensive Cancer Panel (CCP) which covers the most common mutated cancer genes. Our results describe new mutations in CSF …
Here, we use the advantage of Next-generation sequencing (NGS) technology to study the mutation landscape of 12 patients with B-ALL using Co …
272 results