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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1993 2
1996 1
1998 2
1999 3
2000 2
2001 8
2002 7
2003 6
2004 9
2005 15
2006 14
2007 20
2008 20
2009 14
2010 31
2011 35
2012 46
2013 41
2014 62
2015 70
2016 73
2017 79
2018 71
2019 89
2020 100
2021 118
2022 109
2023 113
2024 45

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1,100 results

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Page 1
MYC reshapes CTCF-mediated chromatin architecture in prostate cancer.
Wei Z, Wang S, Xu Y, Wang W, Soares F, Ahmed M, Su P, Wang T, Orouji E, Xu X, Zeng Y, Chen S, Liu X, Jia T, Liu Z, Du L, Wang Y, Chen S, Wang C, He HH, Guo H. Wei Z, et al. Nat Commun. 2023 Mar 30;14(1):1787. doi: 10.1038/s41467-023-37544-3. Nat Commun. 2023. PMID: 36997534 Free PMC article.
MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is the main architectural protein of three-dimensional genome organization. However, the functional link between the two master regulators has not been reported. In this study, w …
MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is the main architectural protein of t …
CTCF and CTCFL in cancer.
Debaugny RE, Skok JA. Debaugny RE, et al. Curr Opin Genet Dev. 2020 Apr;61:44-52. doi: 10.1016/j.gde.2020.02.021. Epub 2020 Apr 22. Curr Opin Genet Dev. 2020. PMID: 32334335 Free PMC article. Review.
CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed CTCF. It plays a unique role in spermatogenesis by regulating expression of testis-specific genes. Genetic alteration …
CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquit …
CTCF: A misguided jack-of-all-trades in cancer cells.
Segueni J, Noordermeer D. Segueni J, et al. Comput Struct Biotechnol J. 2022 May 27;20:2685-2698. doi: 10.1016/j.csbj.2022.05.044. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35685367 Free PMC article. Review.
Here, we summarize how CTCF is involved in the multi-level organization of the human genome and we discuss emerging insights into how perturbed CTCF function and DNA binding causes the activation of oncogenes in cancer cells, mostly through a process of enhan …
Here, we summarize how CTCF is involved in the multi-level organization of the human genome and we discuss emerging insights into how …
Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation.
Fang C, Wang Z, Han C, Safgren SL, Helmin KA, Adelman ER, Serafin V, Basso G, Eagen KP, Gaspar-Maia A, Figueroa ME, Singer BD, Ratan A, Ntziachristos P, Zang C. Fang C, et al. Genome Biol. 2020 Sep 15;21(1):247. doi: 10.1186/s13059-020-02152-7. Genome Biol. 2020. PMID: 32933554 Free PMC article.
However, hitherto there is no comprehensive survey of genome-wide CTCF binding patterns across different human cancers. RESULTS: To dissect functions of CTCF binding, we systematically analyze over 700 CTCF ChIP-seq profiles across human tissues and …
However, hitherto there is no comprehensive survey of genome-wide CTCF binding patterns across different human cancers. RESULT …
CTCF and BORIS in genome regulation and cancer.
Marshall AD, Bailey CG, Rasko JE. Marshall AD, et al. Curr Opin Genet Dev. 2014 Feb;24:8-15. doi: 10.1016/j.gde.2013.10.011. Epub 2013 Dec 14. Curr Opin Genet Dev. 2014. PMID: 24657531 Review.
CTCF and BORIS can be deregulated in cancer. The tumour suppressor gene CTCF can be mutated or deleted in cancer, or CTCF DNA binding can be altered by epigenetic changes. ...However, BORIS can inhibit cell proliferation, and is mutated in ca …
CTCF and BORIS can be deregulated in cancer. The tumour suppressor gene CTCF can be mutated or deleted in cancer …
CTCF promotes colorectal cancer cell proliferation and chemotherapy resistance to 5-FU via the P53-Hedgehog axis.
Lai Q, Li Q, He C, Fang Y, Lin S, Cai J, Ding J, Zhong Q, Zhang Y, Wu C, Wang X, He J, Liu Y, Yan Q, Li A, Liu S. Lai Q, et al. Aging (Albany NY). 2020 Jul 20;12(16):16270-16293. doi: 10.18632/aging.103648. Epub 2020 Jul 20. Aging (Albany NY). 2020. PMID: 32688344 Free PMC article.
CTCF is overexpressed in several cancers and plays crucial roles in regulating aggressiveness, but little is known about whether CTCF drives colorectal cancer progression. Here, we identified a tumor-promoting role for CTCF in colorectal canc …
CTCF is overexpressed in several cancers and plays crucial roles in regulating aggressiveness, but little is known about wheth …
Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress.
Larsen BD, Benada J, Yung PYK, Bell RAV, Pappas G, Urban V, Ahlskog JK, Kuo TT, Janscak P, Megeney LA, Elsässer SJ, Bartek J, Sørensen CS. Larsen BD, et al. Science. 2022 Apr 29;376(6592):476-483. doi: 10.1126/science.abi6378. Epub 2022 Apr 28. Science. 2022. PMID: 35482866
Genotoxic therapy such as radiation serves as a frontline cancer treatment, yet acquired resistance that leads to tumor reoccurrence is frequent. ...In turn, loss of CAD activity impairs cell fate decisions, rendering cancer cells vulnerable to radiation-induced DNA …
Genotoxic therapy such as radiation serves as a frontline cancer treatment, yet acquired resistance that leads to tumor reoccurrence …
Phase separation drives aberrant chromatin looping and cancer development.
Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, Zheng D, Legant WR, Phanstiel DH, Wang GG. Ahn JH, et al. Nature. 2021 Jul;595(7868):591-595. doi: 10.1038/s41586-021-03662-5. Epub 2021 Jun 23. Nature. 2021. PMID: 34163069 Free PMC article.
The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regions (IDRs). ...Deeply sequenced Hi-C revealed that phase-separated NUP98-HOXA9 induces CTCF-independent chromatin loops that are enri …
The development of cancer is intimately associated with genetic abnormalities that target proteins with intrinsically disordered regi …
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia.
Luo H, Zhu G, Eshelman MA, Fung TK, Lai Q, Wang F, Zeisig BB, Lesperance J, Ma X, Chen S, Cesari N, Cogle C, Chen B, Xu B, Yang FC, So CWE, Qiu Y, Xu M, Huang S. Luo H, et al. Mol Cell. 2022 Feb 17;82(4):833-851.e11. doi: 10.1016/j.molcel.2022.01.014. Mol Cell. 2022. PMID: 35180428 Free PMC article.
However, the mechanism through which HOTTIP accesses CCCTC-binding factor (CTCF) chromatin boundaries and regulates CTCF-mediated genome topology remains unknown. Here, we show that HOTTIP directly interacts with and regulates a fraction of CTCF-binding sites …
However, the mechanism through which HOTTIP accesses CCCTC-binding factor (CTCF) chromatin boundaries and regulates CTCF-media …
The co-evolution of the genome and epigenome in colorectal cancer.
Heide T, Househam J, Cresswell GD, Spiteri I, Lynn C, Mossner M, Kimberley C, Fernandez-Mateos J, Chen B, Zapata L, James C, Barozzi I, Chkhaidze K, Nichol D, Gunasri V, Berner A, Schmidt M, Lakatos E, Baker AM, Costa H, Mitchinson M, Piazza R, Jansen M, Caravagna G, Ramazzotti D, Shibata D, Bridgewater J, Rodriguez-Justo M, Magnani L, Graham TA, Sottoriva A. Heide T, et al. Nature. 2022 Nov;611(7937):733-743. doi: 10.1038/s41586-022-05202-1. Epub 2022 Oct 26. Nature. 2022. PMID: 36289335 Free PMC article.
Colorectal malignancies are a leading cause of cancer-related death(1 )and have undergone extensive genomic study(2,3). ...This study provides a map of genetic and epigenetic tumour heterogeneity, with fundamental implications for understanding colorectal cancer bio …
Colorectal malignancies are a leading cause of cancer-related death(1 )and have undergone extensive genomic study(2,3). ...This study …
1,100 results