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19 results

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Page 1
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Wang K, Yuen ST, Xu J, Lee SP, Yan HH, Shi ST, Siu HC, Deng S, Chu KM, Law S, Chan KH, Chan AS, Tsui WY, Ho SL, Chan AK, Man JL, Foglizzo V, Ng MK, Chan AS, Ching YP, Cheng GH, Xie T, Fernandez J, Li VS, Clevers H, Rejto PA, Mao M, Leung SY. Wang K, et al. Nat Genet. 2014 Jun;46(6):573-82. doi: 10.1038/ng.2983. Epub 2014 May 11. Nat Genet. 2014. PMID: 24816253
Gastric cancer is a heterogeneous disease with diverse molecular and histological subtypes. ...We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes. ...
Gastric cancer is a heterogeneous disease with diverse molecular and histological subtypes. ...We identified previously known (TP53, …
Novel-miR-4885 Promotes Migration and Invasion of Esophageal Cancer Cells Through Targeting CTNNA2.
Song J, Zhang P, Liu M, Xie M, Gao Z, Wang X, Wang T, Yin J, Liu R. Song J, et al. DNA Cell Biol. 2019 Feb;38(2):151-161. doi: 10.1089/dna.2018.4377. Epub 2018 Dec 8. DNA Cell Biol. 2019. PMID: 30526004
Esophageal cancer is one of the most common cancers worldwide. It is critical to find early diagnostic biomarkers for esophageal cancer. ...Novel-miR-4885 can bind to 3' untranslated region of CTNNA2 to reduce cell adhesion and promote epithelial-mesen …
Esophageal cancer is one of the most common cancers worldwide. It is critical to find early diagnostic biomarkers for esophage …
Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors.
Wen Y, Lin A, Zhu W, Wei T, Luo P, Guo L, Zhang J. Wen Y, et al. Front Pharmacol. 2021 Jun 7;12:645862. doi: 10.3389/fphar.2021.645862. eCollection 2021. Front Pharmacol. 2021. PMID: 34163353 Free PMC article.
Background: Lung cancer has always been the most prevalent cancer. Lung adenocarcinoma (LUAD) is the most common lung cancer subtype and has a high tumor mutation rate. ...Analysis of the cohort from the Cancer Genome Atlas showed that patients with …
Background: Lung cancer has always been the most prevalent cancer. Lung adenocarcinoma (LUAD) is the most common lung cance …
Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases.
Zhao S, Wang R, Song S, Hao D, Han G, Song X, Zhang J, Pizzi MP, Shanbhag N, Futreal A, Badgwell B, Harada K, Calin G, Vykoukal J, Yu CY, Katayama H, Hanash SM, Wang L, Ajani JA. Zhao S, et al. iScience. 2023 May 19;26(6):106913. doi: 10.1016/j.isci.2023.106913. eCollection 2023 Jun 16. iScience. 2023. PMID: 37305699 Free PMC article.
Integrated analysis revealed enriched biological pathways and notably, some druggable targets (cancer-testis antigens, kinases, and receptors) that could be exploited to develop effective therapies and/or tumor stratifications. Systematic comparison of expression levels of …
Integrated analysis revealed enriched biological pathways and notably, some druggable targets (cancer-testis antigens, kinases, and r …
A novel intergenic (between REG3A and CTNNA2-AS1)-ALK fusion responds to alectinib in lung adenocarcinoma.
Liu Z, Wu Q, Li W, Li P, Huang L, Wang T, Zhou Q. Liu Z, et al. Lung Cancer. 2023 Dec;186:107386. doi: 10.1016/j.lungcan.2023.107386. Epub 2023 Oct 5. Lung Cancer. 2023. PMID: 37922771
Herein, we reported a case of lung adenocarcinoma harboring a novel intergenic (between REG3A and CTNNA2-AS1)-ALK fusion which is sensitive to alectinib. MATERIALS AND METHODS: Hematoxylin-eosin staining (HE), immunohistochemistry (IHC), and DNA-based next-generation seque …
Herein, we reported a case of lung adenocarcinoma harboring a novel intergenic (between REG3A and CTNNA2-AS1)-ALK fusion which is sen …
New functions for alpha-catenins in health and disease: from cancer to heart regeneration.
Vite A, Li J, Radice GL. Vite A, et al. Cell Tissue Res. 2015 Jun;360(3):773-83. doi: 10.1007/s00441-015-2123-x. Epub 2015 Feb 12. Cell Tissue Res. 2015. PMID: 25673211 Free PMC article. Review.
There are three alpha-catenin isoforms expressed in mouse and human: alphaE-catenin (CTNNA1), alphaN-catenin (CTNNA2) and alphaT-catenin (CTNNA3). This review summarizes recent progress in understanding the in vivo function(s) of alpha-catenins in tissue morphogenesis, hom …
There are three alpha-catenin isoforms expressed in mouse and human: alphaE-catenin (CTNNA1), alphaN-catenin (CTNNA2) and alphaT-cate …
Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.
Fanjul-Fernández M, Quesada V, Cabanillas R, Cadiñanos J, Fontanil T, Obaya A, Ramsay AJ, Llorente JL, Astudillo A, Cal S, López-Otín C. Fanjul-Fernández M, et al. Nat Commun. 2013;4:2531. doi: 10.1038/ncomms3531. Nat Commun. 2013. PMID: 24100690 Free article.
Among the 569 genes found to present somatic mutations, and based on their recurrence or functional relevance in cancer, we select 40 for further validation in 86 additional laryngeal carcinomas. We detect frequent mutations (14 of 90, 15%) in CTNNA2 and CTNNA3-enco …
Among the 569 genes found to present somatic mutations, and based on their recurrence or functional relevance in cancer, we select 40 …
Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.
Nakagawa T, Matsusaka K, Misawa K, Ota S, Takane K, Fukuyo M, Rahmutulla B, Shinohara KI, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Nakatani Y, Okamoto Y, Kaneda A. Nakagawa T, et al. Cancer Lett. 2017 Oct 28;407:21-31. doi: 10.1016/j.canlet.2017.08.008. Epub 2017 Aug 18. Cancer Lett. 2017. PMID: 28823962
We performed genome-wide DNA methylation analysis using an Infinium 450k BeadArray for clinical OPSCC and non-cancerous samples and cancer cell lines with/without 5-aza-2'-deoxycytidine and/or trichostatin A treatment. ...The methylation of nine genes (GHSR, ITGA4, …
We performed genome-wide DNA methylation analysis using an Infinium 450k BeadArray for clinical OPSCC and non-cancerous samples and …
Reactivation of silenced α-N-catenin induces retinoic acid sensitivity in neuroblastoma cells.
Clark RA, Newton M, Qiao J, Lee S, Chung DH. Clark RA, et al. Surgery. 2021 Nov;170(5):1546-1553. doi: 10.1016/j.surg.2021.04.039. Epub 2021 Jun 3. Surgery. 2021. PMID: 34092372
We have previously found that alpha-N-catenin, a cell-adhesion protein encoded by the gene CTNNA2, plays a tumor suppressor role in neuroblastoma by inhibiting the NF-kappaB signaling pathway. ...METHODS: Two human neuroblastoma cell lines, SK-N-AS and BE(2)-C, were stably …
We have previously found that alpha-N-catenin, a cell-adhesion protein encoded by the gene CTNNA2, plays a tumor suppressor role in n …
Identification of α-N-catenin as a novel tumor suppressor in neuroblastoma.
Qiao J, Rellinger EJ, Kim KW, Powers CM, Lee S, Correa H, Chung DH. Qiao J, et al. Oncotarget. 2019 Aug 20;10(49):5028-5040. doi: 10.18632/oncotarget.27096. eCollection 2019 Aug 20. Oncotarget. 2019. PMID: 31489113 Free PMC article.
We correlated CTNNA2 (encodes alpha-N-catenin) expression to neuroblastoma disease relapse-free survival probability using publicly accessible human neuroblastoma datasets in R2 platform. ...Forced expression of CTNNA2 decreased cell migration and invasion. Further, …
We correlated CTNNA2 (encodes alpha-N-catenin) expression to neuroblastoma disease relapse-free survival probability using publicly a …
19 results