Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
Zuo T, Xie Q, Liu J, Yang J, Shi J, Kong D, Wang Y, Zhang Z, Gao H, Zeng DB, Wang X, Tao P, Wei W, Wang J, Li Y, Long Q, Li C, Chang L, Ning H, Li Y, Cui C, Ge X, Wu J, Li G, Hong X, Yang X, Dai E, He F, Wu J, Ruan Y, Lu S, Xu P.
Zuo T, et al.
Gastroenterology. 2023 Sep;165(3):746-761.e16. doi: 10.1053/j.gastro.2023.05.039. Epub 2023 May 30.
Gastroenterology. 2023.
PMID: 37263311
Increased serum CTSS levels efficiently predicted liver fibrosis, even at an early stage. ...Further studies identified macrophages as the main source of hepatic CTSS, and splenectomy effectively attenuated macrophage infiltration and CTSS expression in the f …
Increased serum CTSS levels efficiently predicted liver fibrosis, even at an early stage. ...Further studies identified macrophages a …