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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2006 1
2007 1
2008 1
2009 1
2010 2
2011 1
2013 3
2014 2
2015 5
2016 9
2017 7
2018 8
2019 10
2020 14
2021 13
2022 11
2023 20
2024 7

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103 results

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Page 1
Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential.
Smyth P, Sasiwachirangkul J, Williams R, Scott CJ. Smyth P, et al. Mol Aspects Med. 2022 Dec;88:101106. doi: 10.1016/j.mam.2022.101106. Epub 2022 Jul 19. Mol Aspects Med. 2022. PMID: 35868042 Free article. Review.
Increasingly, aberrant CTSS expression has been demonstrated in a variety of conditions and disease states, marking it out as both a biomarker and potential therapeutic target. This review seeks to contextualise CTSS within the cysteine cathepsin family before provi …
Increasingly, aberrant CTSS expression has been demonstrated in a variety of conditions and disease states, marking it out as both a …
Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
Zuo T, Xie Q, Liu J, Yang J, Shi J, Kong D, Wang Y, Zhang Z, Gao H, Zeng DB, Wang X, Tao P, Wei W, Wang J, Li Y, Long Q, Li C, Chang L, Ning H, Li Y, Cui C, Ge X, Wu J, Li G, Hong X, Yang X, Dai E, He F, Wu J, Ruan Y, Lu S, Xu P. Zuo T, et al. Gastroenterology. 2023 Sep;165(3):746-761.e16. doi: 10.1053/j.gastro.2023.05.039. Epub 2023 May 30. Gastroenterology. 2023. PMID: 37263311
Increased serum CTSS levels efficiently predicted liver fibrosis, even at an early stage. ...Further studies identified macrophages as the main source of hepatic CTSS, and splenectomy effectively attenuated macrophage infiltration and CTSS expression in the f …
Increased serum CTSS levels efficiently predicted liver fibrosis, even at an early stage. ...Further studies identified macrophages a …
Neutralization of NET-associated human ARG1 enhances cancer immunotherapy.
Canè S, Barouni RM, Fabbi M, Cuozzo J, Fracasso G, Adamo A, Ugel S, Trovato R, De Sanctis F, Giacca M, Lawlor R, Scarpa A, Rusev B, Lionetto G, Paiella S, Salvia R, Bassi C, Mandruzzato S, Ferrini S, Bronte V. Canè S, et al. Sci Transl Med. 2023 Mar 15;15(687):eabq6221. doi: 10.1126/scitranslmed.abq6221. Epub 2023 Mar 15. Sci Transl Med. 2023. PMID: 36921034
NET-associated hARG1 suppresses T lymphocytes whose proliferation is restored by either adding a hARG1-specific monoclonal antibody (mAb) or preventing CTSS-mediated cleavage, whereas small-molecule inhibitors are not effective. ...Thus, this study shows that extracellular …
NET-associated hARG1 suppresses T lymphocytes whose proliferation is restored by either adding a hARG1-specific monoclonal antibody (mAb) or …
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails.
Shy BR, Vykunta VS, Ha A, Talbot A, Roth TL, Nguyen DN, Pfeifer WG, Chen YY, Blaeschke F, Shifrut E, Vedova S, Mamedov MR, Chung JJ, Li H, Yu R, Wu D, Wolf J, Martin TG, Castro CE, Ye L, Esensten JH, Eyquem J, Marson A. Shy BR, et al. Nat Biotechnol. 2023 Apr;41(4):521-531. doi: 10.1038/s41587-022-01418-8. Epub 2022 Aug 25. Nat Biotechnol. 2023. PMID: 36008610 Free PMC article.
Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with Cas9 target sequences (CTSs) can be toxic to primary cells. Here, we develop single-stranded DNA (ssDNA) H …
Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-directed repair (HDR) using high concentrations of double …
Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response.
Pagadala M, Sears TJ, Wu VH, Pérez-Guijarro E, Kim H, Castro A, Talwar JV, Gonzalez-Colin C, Cao S, Schmiedel BJ, Goudarzi S, Kirani D, Au J, Zhang T, Landi T, Salem RM, Morris GP, Harismendy O, Patel SP, Alexandrov LB, Mesirov JP, Zanetti M, Day CP, Fan CC, Thompson WK, Merlino G, Gutkind JS, Vijayanand P, Carter H. Pagadala M, et al. Nat Commun. 2023 May 12;14(1):2744. doi: 10.1038/s41467-023-38271-5. Nat Commun. 2023. PMID: 37173324 Free PMC article.
With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. ...To assess whether an eQTL-informed approa …
With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune micr …
Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers.
Ren F, Jin Q, Liu T, Ren X, Zhan Y. Ren F, et al. J Transl Med. 2023 Sep 21;21(1):646. doi: 10.1186/s12967-023-04525-5. J Transl Med. 2023. PMID: 37735436 Free PMC article.
BACKGROUND: The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatment strategies have been developed and employed, there are still significant limitations and challenges in the early diagnosis and tar …
BACKGROUND: The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted …
BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma.
Kremenovic M, Chan AA, Feng B, Bäriswyl L, Robatel S, Gruber T, Tang L, Lee DJ, Schenk M. Kremenovic M, et al. J Immunother Cancer. 2022 Jun;10(6):e004133. doi: 10.1136/jitc-2021-004133. J Immunother Cancer. 2022. PMID: 35732347 Free PMC article.
In human patients with melanoma, intralesional-BCG treatment was associated with enhanced M1 Mphi, mature DC, antigen processing and presentation, as well as with increased CTSS expression which positively correlated with patient survival. CONCLUSIONS: These findings provi …
In human patients with melanoma, intralesional-BCG treatment was associated with enhanced M1 Mphi, mature DC, antigen processing and present …
Prognostic value and immunological role of cathepsin S gene in pan-cancer.
Liang S, Dang B, Chen S, Mi H. Liang S, et al. Oncol Lett. 2023 Dec 4;27(1):41. doi: 10.3892/ol.2023.14175. eCollection 2024 Jan. Oncol Lett. 2023. PMID: 38108072 Free PMC article.
Nevertheless, the precise impact of CTSS on predicting pan-cancer prognosis and its influence on the tumor microenvironment and immune infiltration in human cancers remains unknown. ...The current study demonstrated abnormal expression and distinct genomic al …
Nevertheless, the precise impact of CTSS on predicting pan-cancer prognosis and its influence on the tumor microenvironment an …
Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells.
Choi E, Jeon KH, Lee H, Mun GI, Kim JA, Shin JH, Kwon Y, Na Y, Lee YS. Choi E, et al. Cancer Sci. 2024 Apr 13. doi: 10.1111/cas.16174. Online ahead of print. Cancer Sci. 2024. PMID: 38613358 Free article.
Triple-negative breast cancer (TNBC) patients harboring wild-type breast cancer susceptibility gene 1 (BRCA1) account for most TNBC patients but lack adequate targeted therapeutic options. ...Publicly available data and human tissue microarray slides were analyzed t …
Triple-negative breast cancer (TNBC) patients harboring wild-type breast cancer susceptibility gene 1 (BRCA1) account for most …
Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion.
Guo Z, Zhang H, Liu X, Zhao Y, Chen Y, Jin J, Guo C, Zhang M, Gu F, Ma Y. Guo Z, et al. J Exp Clin Cancer Res. 2023 Feb 20;42(1):49. doi: 10.1186/s13046-023-02616-1. J Exp Clin Cancer Res. 2023. PMID: 36803413 Free PMC article.
Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a crucial target in breast cancer local invasion. ...In addition, cytoplasmic AQP1 recruited cytosolic free Rab1b to the Golgi apparatus to form …
Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a crucial ta …
103 results