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54 results

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Page 1
CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination.
Kong Y, Wang Z, Huang M, Zhou Z, Li Y, Miao H, Wan X, Huang J, Mao X, Chen C. Kong Y, et al. Int J Cancer. 2019 Sep 1;145(5):1371-1381. doi: 10.1002/ijc.32239. Epub 2019 Mar 18. Int J Cancer. 2019. PMID: 30807646 Free article.
Accumulated evidence suggests that CUL7 is oncogenic. However, the mechanism by which CUL7 improves cancer cell survival has not been fully elucidated. ...CUL7 knockdown sensitized cancer cells to TRAIL-induced apoptosis in vitro and in nude mic …
Accumulated evidence suggests that CUL7 is oncogenic. However, the mechanism by which CUL7 improves cancer cell surviva …
Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-kappaB activation.
Xu J, Zhang Z, Qian M, Wang S, Qiu W, Chen Z, Sun Z, Xiong Y, Wang C, Sun X, Zhao R, Xue H, Li G. Xu J, et al. J Exp Clin Cancer Res. 2020 Apr 6;39(1):59. doi: 10.1186/s13046-020-01553-7. J Exp Clin Cancer Res. 2020. PMID: 32252802 Free PMC article.
CUL7 overexpression was performed using the GV141-CUL7 plasmid construct. ...Furthermore, CUL7 might be a candidate molecular target for the treatment of glioma....
CUL7 overexpression was performed using the GV141-CUL7 plasmid construct. ...Furthermore, CUL7 might be a candidate mol …
Identification and verification of the prognostic value of CUL7 in colon adenocarcinoma.
Wang C, Zhao Z, Zhang Y, Liang W, Zhou C, Lin W, He Y, Wu M, Meng Z, Liao Y, Li M, El Akkawi M, Zhao J, He Y. Wang C, et al. Front Immunol. 2022 Oct 11;13:1043512. doi: 10.3389/fimmu.2022.1043512. eCollection 2022. Front Immunol. 2022. PMID: 36304472 Free PMC article.
In colorectal cancer, CUL7 was overexpressed in tumor tissues by IHC with a mutation frequency of about 4%. CUL7 is an independent prognostic factor for colorectal cancer. The nomogram constructed has effective predictive performance, and external data …
In colorectal cancer, CUL7 was overexpressed in tumor tissues by IHC with a mutation frequency of about 4%. CUL7 is an …
Cullin 7 in tumor development: a novel potential anti-cancer target.
Li Y, Zang A, Fu J, Jia Y. Li Y, et al. Neoplasma. 2021 May;68(3):572-579. doi: 10.4149/neo_2021_201207N1324. Epub 2021 Feb 24. Neoplasma. 2021. PMID: 33618520 Review.
Cul7 is highly expressed in breast cancer, lung cancer, hepatocellular carcinoma, pancreatic cancer, ovarian cancer, and other malignant tumors where Cul7 promotes tumor development, cell transformation, and cell survival by regulating co …
Cul7 is highly expressed in breast cancer, lung cancer, hepatocellular carcinoma, pancreatic cancer, ovarian …
The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer.
Shi L, Du D, Peng Y, Liu J, Long J. Shi L, et al. Oncogenesis. 2020 Oct 31;9(10):98. doi: 10.1038/s41389-020-00276-w. Oncogenesis. 2020. PMID: 33130829 Free PMC article. Review.
Cullin (CUL) proteins have critical roles in development and cancer, however few studies on CUL7 have been reported due to its characteristic molecular structure. ...Currently, the mechanism of CUL7 in cancer remains unclear, and no studies have addres …
Cullin (CUL) proteins have critical roles in development and cancer, however few studies on CUL7 have been reported due to its …
Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer.
Pan ZQ. Pan ZQ. Adv Exp Med Biol. 2020;1217:285-296. doi: 10.1007/978-981-15-1025-0_17. Adv Exp Med Biol. 2020. PMID: 31898234 Free PMC article. Review.
This chapter provides an update on studies linking CRL7(Fbxw8) to hereditary human growth retardation disease, as at least 64 cul7 germ line mutations were found in patients with autosomal recessive 3-M syndrome. ...Discussion focuses on the possible impact of CRL7(Fbxw8)- …
This chapter provides an update on studies linking CRL7(Fbxw8) to hereditary human growth retardation disease, as at least 64 cul7 ge …
CUL7 is a novel antiapoptotic oncogene.
Kim SS, Shago M, Kaustov L, Boutros PC, Clendening JW, Sheng Y, Trentin GA, Barsyte-Lovejoy D, Mao DY, Kay R, Jurisica I, Arrowsmith CH, Penn LZ. Kim SS, et al. Cancer Res. 2007 Oct 15;67(20):9616-22. doi: 10.1158/0008-5472.CAN-07-0644. Cancer Res. 2007. PMID: 17942889
Deregulated expression of the Myc oncogene drives cellular proliferation yet also sensitizes cells to undergo p53-dependent and p53-independent apoptosis. Here, we report that CUL7 exerts its antiapoptotic function through p53. CUL7 binds directly to p53, and small …
Deregulated expression of the Myc oncogene drives cellular proliferation yet also sensitizes cells to undergo p53-dependent and p53-independ …
The role of cullin proteins in gastric cancer.
Chen P, Yao GD. Chen P, et al. Tumour Biol. 2016 Jan;37(1):29-37. doi: 10.1007/s13277-015-4154-z. Epub 2015 Oct 15. Tumour Biol. 2016. PMID: 26472722 Review.
There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein. All of these proteins contain a conserved cullin homology domain that binds to RING box proteins. ...The …
There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associate …
PARC and CUL7 form atypical cullin RING ligase complexes.
Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA. Skaar JR, et al. Cancer Res. 2007 Mar 1;67(5):2006-14. doi: 10.1158/0008-5472.CAN-06-3241. Cancer Res. 2007. PMID: 17332328
Multidimensional protein identification technology analysis revealed that the CUL7 interaction with FBXW8 was mutually exclusive of CUL7 binding to PARC or p53. Notably, although heterodimers of CUL7 and PARC bind p53, p53 is not required for the dimerization …
Multidimensional protein identification technology analysis revealed that the CUL7 interaction with FBXW8 was mutually exclusive of …
A novel p53-binding domain in CUL7.
Kasper JS, Arai T, DeCaprio JA. Kasper JS, et al. Biochem Biophys Res Commun. 2006 Sep 15;348(1):132-8. doi: 10.1016/j.bbrc.2006.07.013. Epub 2006 Jul 13. Biochem Biophys Res Commun. 2006. PMID: 16875676
CUL7 is a member of the cullin RING ligase family and forms an SCF-like complex with SKP1 and FBXW8. ...The presence of p53 stabilized expression of this domain and we demonstrate that this p53-binding domain of CUL7 contributes to the cytoplasmic localization of …
CUL7 is a member of the cullin RING ligase family and forms an SCF-like complex with SKP1 and FBXW8. ...The presence of p53 stabilize …
54 results