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CXXC5 expression in prostate cancer: implications for cancer progression.
Benedetti I, De Marzo AM, Geliebter J, Reyes N. Benedetti I, et al. Int J Exp Pathol. 2017 Aug;98(4):234-243. doi: 10.1111/iep.12241. Int J Exp Pathol. 2017. PMID: 29027288 Free PMC article.
We previously found differential expression of CXXC5 transcripts in metastatic prostate cancer cell lines of both rat and human origin. ...Additional studies are required to determine the biological and clinical significance of CXXC5 in prostate cancer …
We previously found differential expression of CXXC5 transcripts in metastatic prostate cancer cell lines of both rat and huma …
A noncanonical AR addiction drives enzalutamide resistance in prostate cancer.
He Y, Wei T, Ye Z, Orme JJ, Lin D, Sheng H, Fazli L, Jeffrey Karnes R, Jimenez R, Wang L, Wang L, Gleave ME, Wang Y, Shi L, Huang H. He Y, et al. Nat Commun. 2021 Mar 9;12(1):1521. doi: 10.1038/s41467-021-21860-7. Nat Commun. 2021. PMID: 33750801 Free PMC article.
Resistance to next-generation anti-androgen enzalutamide (ENZ) constitutes a major challenge for the treatment of castration-resistant prostate cancer (CRPC). By performing genome-wide ChIP-seq profiling in ENZ-resistant CRPC cells we identify a set of androgen receptor (A …
Resistance to next-generation anti-androgen enzalutamide (ENZ) constitutes a major challenge for the treatment of castration-resistant prost …
CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.
Geng T, Sun Q, He J, Chen Y, Cheng W, Shen J, Liu B, Zhang M, Wang S, Asan K, Song M, Gao Q, Song Y, Liu R, Liu X, Ding Y, Jing A, Ye X, Ren H, Zeng K, Zhou Y, Zhang B, Ma S, Liu W, Liu S, Ji J. Geng T, et al. Cell Signal. 2024 Jul;119:111180. doi: 10.1016/j.cellsig.2024.111180. Epub 2024 Apr 19. Cell Signal. 2024. PMID: 38642782
Despite its known role in cancer, CXXC5's function and mechanism in ovarian cancer are unclear. ...Through in vitro and in vivo experiments, we confirmed ZNF143 and EGR1 as downstream transcription factors of CXXC5, mediating its proliferative potentia …
Despite its known role in cancer, CXXC5's function and mechanism in ovarian cancer are unclear. ...Through in vitro and …
Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer.
Fang L, Wang Y, Gao Y, Chen X. Fang L, et al. Oncol Lett. 2018 Jul;16(1):395-401. doi: 10.3892/ol.2018.8647. Epub 2018 May 7. Oncol Lett. 2018. PMID: 29928427 Free PMC article.
Basal-like breast cancer and triple-negative breast cancer also suggest a poor prognosis, however their CXXC5 expression was low and could not be used as a prognostic factor. ...However, the role of CXXC5 in breast cancer requires further invest …
Basal-like breast cancer and triple-negative breast cancer also suggest a poor prognosis, however their CXXC5 expressio …
Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
Wang W, Zhang Z, Zhao M, Wang Y, Ge Y, Shan L. Wang W, et al. J Biol Chem. 2023 Jan;299(1):102812. doi: 10.1016/j.jbc.2022.102812. Epub 2022 Dec 17. J Biol Chem. 2023. PMID: 36539038 Free PMC article.
We also found that the CXXC5-CRL4B-NuRD complex promotes the proliferation of tumor cells in vitro and accelerates the growth of breast cancer in vivo. The expression of CXXC5, CUL4B, and MTA1 increased during the occurrence and development of breast cance …
We also found that the CXXC5-CRL4B-NuRD complex promotes the proliferation of tumor cells in vitro and accelerates the growth of brea …
CXXC5: A novel regulator and coordinator of TGF-beta, BMP and Wnt signaling.
Xiong X, Tu S, Wang J, Luo S, Yan X. Xiong X, et al. J Cell Mol Med. 2019 Feb;23(2):740-749. doi: 10.1111/jcmm.14046. Epub 2018 Nov 27. J Cell Mol Med. 2019. PMID: 30479059 Free PMC article. Review.
Intriguingly, increasing evidence indicates that expression of the CXXC5 gene is controlled by multiple signaling pathways and a variety of transcription factors, positioning CXXC5 as an important signal integrator. ...This review summarizes the current understandin …
Intriguingly, increasing evidence indicates that expression of the CXXC5 gene is controlled by multiple signaling pathways and a vari …
Undifferentially Expressed CXXC5 as a Transcriptionally Regulatory Biomarker of Breast Cancer.
Li X, Lv X, Li H, Zhang G, Long Y, Li K, Fan Y, Jin D, Zhou F, Liu H. Li X, et al. Adv Biol (Weinh). 2023 Dec;7(12):e2300189. doi: 10.1002/adbi.202300189. Epub 2023 Jul 9. Adv Biol (Weinh). 2023. PMID: 37423953
This work hypothesizes that some genes undergo radically changed transcription regulations (TRs) in breast cancer (BC), but don't show differential expressions for unknown reasons. ...Although CXXC5 does not show differential expressions in BC, its transcription reg …
This work hypothesizes that some genes undergo radically changed transcription regulations (TRs) in breast cancer (BC), but don't sho …
CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation.
Ayaz G, Razizadeh N, Yaşar P, Kars G, Kahraman DC, Saatci Ö, Şahin Ö, Çetin-Atalay R, Muyan M. Ayaz G, et al. Sci Rep. 2020 Apr 6;10(1):5971. doi: 10.1038/s41598-020-62912-0. Sci Rep. 2020. PMID: 32249801 Free PMC article.
Furthermore, we found that the overexpression of CXXC5, which correlates with mRNA and protein levels of ERalpha, associates with poor prognosis in ER-positive breast cancer patients. Thus, CXXC5 as an unmethylated CpG binder contributes to E2-mediated gene e …
Furthermore, we found that the overexpression of CXXC5, which correlates with mRNA and protein levels of ERalpha, associates with poo …
A prelude to the proximity interaction mapping of CXXC5.
Ayaz G, Turan G, Olgun ÇE, Kars G, Karakaya B, Yavuz K, Demiralay ÖD, Can T, Muyan M, Yaşar P. Ayaz G, et al. Sci Rep. 2021 Sep 2;11(1):17587. doi: 10.1038/s41598-021-97060-6. Sci Rep. 2021. PMID: 34475492 Free PMC article.
Furthermore, an interplay between CXXC5 and MeCP2 was critical for a subset of CXXC5 target gene expressions. ...Providing a prelude for CXXC5 actions, our results could also contribute to a better understanding of CXXC5-mediated cellular processes in …
Furthermore, an interplay between CXXC5 and MeCP2 was critical for a subset of CXXC5 target gene expressions. ...Providing a p …
A CpG island promoter drives the CXXC5 gene expression.
Yaşar P, Kars G, Yavuz K, Ayaz G, Oğuztüzün Ç, Bilgen E, Suvacı Z, Çetinkol ÖP, Can T, Muyan M. Yaşar P, et al. Sci Rep. 2021 Aug 2;11(1):15655. doi: 10.1038/s41598-021-95165-6. Sci Rep. 2021. PMID: 34341443 Free PMC article.
CXXC5 is a member of the zinc-finger CXXC family that binds to unmethylated CpG dinucleotides. ...Of the TFs, we verified that ELF1 and MAZ contribute to CXXC5 expression. Moreover, the first exon of variant 2 may contain a G-quadruplex forming region that could mod …
CXXC5 is a member of the zinc-finger CXXC family that binds to unmethylated CpG dinucleotides. ...Of the TFs, we verified that ELF1 a …
42 results