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Year Number of Results
1975 1
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1988 1
1989 2
1990 1
1991 3
1992 3
1993 3
1994 1
1995 4
1997 4
1998 6
1999 2
2000 2
2001 5
2002 5
2003 4
2004 7
2005 11
2006 4
2007 10
2008 6
2009 6
2010 16
2011 26
2012 16
2013 13
2014 14
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2020 32
2021 23
2022 31
2023 25
2024 18

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361 results

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CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer.
Li K, Chen Y. Li K, et al. Cancer Biol Ther. 2020 Dec 1;21(12):1145-1153. doi: 10.1080/15384047.2020.1840886. Epub 2020 Nov 12. Cancer Biol Ther. 2020. PMID: 33180658 Free PMC article.
A cornucopia of literatures has characterized the involvement of a host of functional molecules in liver cancer. Herein, according to online datasets, we found that cytochrome P450 family 2 subfamily C member 8 (CYP2C8) was downregulated in liver cancer …
A cornucopia of literatures has characterized the involvement of a host of functional molecules in liver cancer. Herein, according to …
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments.
Gougis P, Hilmi M, Geraud A, Mir O, Funck-Brentano C. Gougis P, et al. Crit Rev Oncol Hematol. 2021 Oct;166:103342. doi: 10.1016/j.critrevonc.2021.103342. Epub 2021 Apr 28. Crit Rev Oncol Hematol. 2021. PMID: 33930533 Free article. Review.
Herbs, food and dietary supplements (HFDS), can interact significantly with anticancer drug treatments via cytochrome p450 isoforms (CYP) CYP3A4, CYP2D6, CYP1A2, and CYP2C8. The objective of this review was to assess the influence of HFDS compounds on these cytochro …
Herbs, food and dietary supplements (HFDS), can interact significantly with anticancer drug treatments via cytochrome p450 isoforms ( …
The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility.
Qu W, Zhang F, Cheng Y, Li J, Zhou J. Qu W, et al. Front Endocrinol (Lausanne). 2022 Sep 28;13:989030. doi: 10.3389/fendo.2022.989030. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36246885 Free PMC article.
Previous studies have indicated that genetic factors are significantly associated with bladder cancer progression-for instance, the CYP2C8 gene is involved in bladder cancer progression. However, little is known about the impact of CYP2C8 genetic polym …
Previous studies have indicated that genetic factors are significantly associated with bladder cancer progression-for instance, the …
Lovastatin enhances chemosensitivity of paclitaxel-resistant prostate cancer cells through inhibition of CYP2C8.
Li Y, Chen S, Zhu J, Zheng C, Wu M, Xue L, He G, Fu S, Deng X. Li Y, et al. Biochem Biophys Res Commun. 2022 Jan 22;589:85-91. doi: 10.1016/j.bbrc.2021.12.007. Epub 2021 Dec 3. Biochem Biophys Res Commun. 2022. PMID: 34896780
Chemotherapy is the mainstay of treatment for prostate cancer, with paclitaxel being commonly used for hormone-resistant prostate cancer. ...Our results suggest that LV might increase the sensitivity of resistant prostate cancer cells to paclitaxel through in …
Chemotherapy is the mainstay of treatment for prostate cancer, with paclitaxel being commonly used for hormone-resistant prostate …
Drug metabolism and drug transport of the 100 most prescribed oral drugs.
Iversen DB, Andersen NE, Dalgård Dunvald AC, Pottegård A, Stage TB. Iversen DB, et al. Basic Clin Pharmacol Toxicol. 2022 Nov;131(5):311-324. doi: 10.1111/bcpt.13780. Epub 2022 Aug 24. Basic Clin Pharmacol Toxicol. 2022. PMID: 35972991 Free PMC article. Review.
CYP3A4/5 is the most important Phase I enzyme involved in metabolism of 43 drugs followed by CYP2D6 (23 drugs), CYP2C9 (23 drugs), CYP2C19 (22 drugs), CYP1A2 (14 drugs) and CYP2C8 (11 drugs). More than half of the drugs (54 drugs) are known substrates for drug transporters …
CYP3A4/5 is the most important Phase I enzyme involved in metabolism of 43 drugs followed by CYP2D6 (23 drugs), CYP2C9 (23 drugs), CYP2C19 ( …
Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective.
Nthontho KC, Ndlovu AK, Sharma K, Kasvosve I, Hertz DL, Paganotti GM. Nthontho KC, et al. Pharmgenomics Pers Med. 2022 Jun 21;15:613-652. doi: 10.2147/PGPM.S308531. eCollection 2022. Pharmgenomics Pers Med. 2022. PMID: 35761855 Free PMC article. Review.
Breast cancer is the most frequent cause of cancer death in low- and middle-income countries, in particular among sub-Saharan African women, where response to available anticancer treatment therapy is often limited by the recurrent breast tumours and metastasis, ult …
Breast cancer is the most frequent cause of cancer death in low- and middle-income countries, in particular among sub-Saharan …
CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel.
Hertz DL, Motsinger-Reif AA, Drobish A, Winham SJ, McLeod HL, Carey LA, Dees EC. Hertz DL, et al. Breast Cancer Res Treat. 2012 Jul;134(1):401-10. doi: 10.1007/s10549-012-2054-0. Epub 2012 Apr 18. Breast Cancer Res Treat. 2012. PMID: 22527101 Free PMC article.
Patient and tumor characteristics and treatment outcomes were collected prospectively for breast cancer patients treated with paclitaxel-containing regimens in the neoadjuvant setting. ...Overall, cCR was 30.1% to the paclitaxel component. CYP2C8*3 carriers (23/111, …
Patient and tumor characteristics and treatment outcomes were collected prospectively for breast cancer patients treated with paclita …
Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy.
Manhas D, Bhatt S, Rai G, Kumar V, Bharti S, Dhiman S, Jain SK, Sharma DK, Ojha PK, Gandhi SG, Goswami A, Nandi U. Manhas D, et al. Chem Biol Interact. 2023 Aug 1;380:110524. doi: 10.1016/j.cbi.2023.110524. Epub 2023 May 3. Chem Biol Interact. 2023. PMID: 37146929
CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids (EETs) that cause cancer progression. ...Rottlerin substantially hindered the EET formation in HLM. Overall results of rottlerin on CYP2C8 inhibition and EET formation insinuate further exploration …
CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids (EETs) that cause cancer progression. ...Rottlerin substantially …
Polymorphisms in Phase I (CYP450) Genes CYP1A1 (rs4646421), CYP1B1 (rs1056836), CYP19A1 (rs749292) and CYP2C8 (rs1058930) and Their Relation to Risk of Breast Cancer: A Case-Control Study in Mazandaran Province in North of Iran.
Golmohammadzadeh G, Mohammadpour A, Ahangar N, Shokrzadeh M. Golmohammadzadeh G, et al. Open Access Maced J Med Sci. 2019 Aug 10;7(15):2488-2496. doi: 10.3889/oamjms.2019.667. eCollection 2019 Aug 15. Open Access Maced J Med Sci. 2019. PMID: 31666853 Free PMC article.
Based on using a logistic regression model in two normalized and age-adjusted models to finding relationship between the genotypes of each gene and breast cancer risk, it was determined that in the CYP2C8 genotype, those who have the CG allele have a 7.74 degree inc …
Based on using a logistic regression model in two normalized and age-adjusted models to finding relationship between the genotypes of each g …
Buprenorphine in cancer pain.
Davis MP. Davis MP. Support Care Cancer. 2005 Nov;13(11):878-87. doi: 10.1007/s00520-005-0849-9. Epub 2005 Jul 12. Support Care Cancer. 2005. PMID: 16010532 Review.
Buprenorphine can be given by several routes. Metabolism is through CYP3A4 and CYP2C8 and by conjugases. Constipation and sexual dysfunction appear to be less with buprenorphine than with other opioids. ...Sublingual buprenorphine has been combined with naloxone to prevent …
Buprenorphine can be given by several routes. Metabolism is through CYP3A4 and CYP2C8 and by conjugases. Constipation and sexual dysf …
361 results