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Page 1
Cytochrome P450 omega-Hydroxylases in Inflammation and Cancer.
Johnson AL, Edson KZ, Totah RA, Rettie AE. Johnson AL, et al. Adv Pharmacol. 2015;74:223-62. doi: 10.1016/bs.apha.2015.05.002. Epub 2015 Jun 27. Adv Pharmacol. 2015. PMID: 26233909 Free PMC article. Review.
Eicosanoids, derived from arachidonic acid, are key substrates in the latter category. Human CYP4 enzymes, mainly CYP4A11, CYP4F2, and CYP4F3B, hydroxylate arachidonic acid at the omega position to form 20-HETE, which has important effects in tumor progression and on angio …
Eicosanoids, derived from arachidonic acid, are key substrates in the latter category. Human CYP4 enzymes, mainly CYP4A11, CYP4F2, an …
Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications.
Kim S, Kim JM, Lee HJ, Lim JS, Seong IO, Kim KH. Kim S, et al. J Cancer. 2020 Jan 14;11(6):1478-1485. doi: 10.7150/jca.36438. eCollection 2020. J Cancer. 2020. PMID: 32047554 Free PMC article.
Background: Cytochrome P-450 4A11 (CYP4A11) and peroxisome proliferator-activated receptor-alpha (PPARalpha) are expressed at high levels in renal proximal tubules, and upregulation of CYP4A11 protein levels is known to be influenced by PPAR agonists. ...Conclusion: …
Background: Cytochrome P-450 4A11 (CYP4A11) and peroxisome proliferator-activated receptor-alpha (PPARalpha) are expressed at high le …
Immunohistochemical expression of cytochrome P4A11 (CYP4A11), carbonic anhydrase 9 (CAIX) and Ki67 in renal cell carcinoma; diagnostic relevance and relations to clinicopathological parameters.
Elfakharany HK, Ghoraba HM, Gaweesh KA, Eldeen AAS, Eid AM. Elfakharany HK, et al. Pathol Res Pract. 2024 Jan;253:155070. doi: 10.1016/j.prp.2023.155070. Epub 2024 Jan 3. Pathol Res Pract. 2024. PMID: 38183818
Carbonic Anhydrase 9 (CAIX) is a transmembrane protein that plays an integral part in regulating hypoxia which affects cancer cell metabolism, proliferation and promotes metastasis. The aim of this study was to evaluate the immunohistochemical expression of CYP4A11, …
Carbonic Anhydrase 9 (CAIX) is a transmembrane protein that plays an integral part in regulating hypoxia which affects cancer cell me …
CYP4A11 is repressed by retinoic acid in human liver cells.
Antoun J, Amet Y, Simon B, Dréano Y, Corlu A, Corcos L, Salaun JP, Plée-Gautier E. Antoun J, et al. FEBS Lett. 2006 Jun 12;580(14):3361-7. doi: 10.1016/j.febslet.2006.05.006. Epub 2006 May 11. FEBS Lett. 2006. PMID: 16712844 Free article.
CYP4A11, the major fatty acid omega-hydroxylase in human liver is involved in the balance of lipids, but its role and regulation are both poorly understood. ...Such a strong suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metab …
CYP4A11, the major fatty acid omega-hydroxylase in human liver is involved in the balance of lipids, but its role and regulation are …
Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity.
Quintanilha JCF, de Sousa VM, Visacri MB, Amaral LS, Santos RMM, Zambrano T, Salazar LA, Moriel P. Quintanilha JCF, et al. Cancer Chemother Pharmacol. 2017 Aug;80(2):223-233. doi: 10.1007/s00280-017-3358-x. Epub 2017 Jun 13. Cancer Chemother Pharmacol. 2017. PMID: 28612092 Review.
RESULTS: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2E1 and CYP4A11. The studies also suggested that the cisplatin and CYP2E1 interaction leads to the generation of reactive oxygen speci …
RESULTS: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2 …
Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data.
de Matos Simoes R, Dalleau S, Williamson KE, Emmert-Streib F. de Matos Simoes R, et al. BMC Syst Biol. 2015 May 14;9:21. doi: 10.1186/s12918-015-0165-z. BMC Syst Biol. 2015. PMID: 25971253 Free PMC article.
We investigated the structural and functional properties of GRNs for the identification of molecular targets associated to urothelial cancer. RESULTS: We found that the urothelial cancer (UC) GRNs show a significant enrichment of subnetworks that are associated with …
We investigated the structural and functional properties of GRNs for the identification of molecular targets associated to urothelial can …
Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer.
Hertz DL, Kidwell KM, Seewald NJ, Gersch CL, Desta Z, Flockhart DA, Storniolo AM, Stearns V, Skaar TC, Hayes DF, Henry NL, Rae JM. Hertz DL, et al. Pharmacogenomics J. 2017 Dec;17(6):521-527. doi: 10.1038/tpj.2016.60. Epub 2016 Aug 23. Pharmacogenomics J. 2017. PMID: 27549341 Free PMC article.
Additional SNPs in genes relevant to exemestane metabolism (CYP1A1/2, CYP1B1, CYP3A4, CYP4A11, AKR1C3/4, AKR7A2) were screened in secondary analyses and adjusted for clinical covariates. ...These genetic and clinical predictors of exemestane concentration may be useful for …
Additional SNPs in genes relevant to exemestane metabolism (CYP1A1/2, CYP1B1, CYP3A4, CYP4A11, AKR1C3/4, AKR7A2) were screened in sec …
Exosome-related protein CRABP2 is upregulated in ovarian carcinoma and enhances cell proliferation.
Li N, Lin G, Zhang Y, Zhang Q, Zhang H. Li N, et al. Discov Oncol. 2022 May 16;13(1):33. doi: 10.1007/s12672-022-00492-3. Discov Oncol. 2022. PMID: 35578123 Free PMC article.
Ovarian cancer is the most lethal cancer among women worldwide. Early diagnosis of ovarian cancer is a considerable challenge for gynecological oncologists. ...At the same time, overexpression of CRABP2 can upregulate oxidative metabolism-related genes such a …
Ovarian cancer is the most lethal cancer among women worldwide. Early diagnosis of ovarian cancer is a considerable cha …
Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications.
Jarrar YB, Lee SJ. Jarrar YB, et al. Int J Mol Sci. 2019 Aug 31;20(17):4274. doi: 10.3390/ijms20174274. Int J Mol Sci. 2019. PMID: 31480463 Free PMC article. Review.
As CYP4 enzymes play a role in the maintenance of fatty acids and fatty-acid-derived bioactive molecules within a normal range, they have been implicated in various biological functions, including inflammation, skin barrier, eye function, cardiovascular health, and cancer. …
As CYP4 enzymes play a role in the maintenance of fatty acids and fatty-acid-derived bioactive molecules within a normal range, they have be …
Cytochrome P450 omega-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer.
Yu W, Chen L, Yang YQ, Falck JR, Guo AM, Li Y, Yang J. Yu W, et al. Cancer Chemother Pharmacol. 2011 Sep;68(3):619-29. doi: 10.1007/s00280-010-1521-8. Epub 2010 Dec 1. Cancer Chemother Pharmacol. 2011. PMID: 21120482 Free PMC article.
The present study examined the role of CYP omega-hydroxylase in angiogenesis and metastasis of human non-small cell lung cancer (NSCLC). METHODS: The effect of WIT003, a stable 20-HETE analog, on invasion was evaluated using a modified Boyden chamber in three NSCLC cell li …
The present study examined the role of CYP omega-hydroxylase in angiogenesis and metastasis of human non-small cell lung cancer (NSCL …
40 results