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42 results

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Page 1
Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications.
Kim S, Kim JM, Lee HJ, Lim JS, Seong IO, Kim KH. Kim S, et al. J Cancer. 2020 Jan 14;11(6):1478-1485. doi: 10.7150/jca.36438. eCollection 2020. J Cancer. 2020. PMID: 32047554 Free PMC article.
Background: Cytochrome P-450 4A11 (CYP4A11) and peroxisome proliferator-activated receptor-alpha (PPARalpha) are expressed at high levels in renal proximal tubules, and upregulation of CYP4A11 protein levels is known to be influenced by PPAR agonists. ...The conside …
Background: Cytochrome P-450 4A11 (CYP4A11) and peroxisome proliferator-activated receptor-alpha (PPARalpha) are expressed at high le …
Cytochrome P450 omega-Hydroxylases in Inflammation and Cancer.
Johnson AL, Edson KZ, Totah RA, Rettie AE. Johnson AL, et al. Adv Pharmacol. 2015;74:223-62. doi: 10.1016/bs.apha.2015.05.002. Epub 2015 Jun 27. Adv Pharmacol. 2015. PMID: 26233909 Free PMC article. Review.
Eicosanoids, derived from arachidonic acid, are key substrates in the latter category. Human CYP4 enzymes, mainly CYP4A11, CYP4F2, and CYP4F3B, hydroxylate arachidonic acid at the omega position to form 20-HETE, which has important effects in tumor progression and on angio …
Eicosanoids, derived from arachidonic acid, are key substrates in the latter category. Human CYP4 enzymes, mainly CYP4A11, CYP4F2, an …
Immunohistochemical expression of cytochrome P4A11 (CYP4A11), carbonic anhydrase 9 (CAIX) and Ki67 in renal cell carcinoma; diagnostic relevance and relations to clinicopathological parameters.
Elfakharany HK, Ghoraba HM, Gaweesh KA, Eldeen AAS, Eid AM. Elfakharany HK, et al. Pathol Res Pract. 2024 Jan;253:155070. doi: 10.1016/j.prp.2023.155070. Epub 2024 Jan 3. Pathol Res Pract. 2024. PMID: 38183818
Carbonic Anhydrase 9 (CAIX) is a transmembrane protein that plays an integral part in regulating hypoxia which affects cancer cell metabolism, proliferation and promotes metastasis. The aim of this study was to evaluate the immunohistochemical expression of CYP4A11, …
Carbonic Anhydrase 9 (CAIX) is a transmembrane protein that plays an integral part in regulating hypoxia which affects cancer cell me …
CYP4A11 is repressed by retinoic acid in human liver cells.
Antoun J, Amet Y, Simon B, Dréano Y, Corlu A, Corcos L, Salaun JP, Plée-Gautier E. Antoun J, et al. FEBS Lett. 2006 Jun 12;580(14):3361-7. doi: 10.1016/j.febslet.2006.05.006. Epub 2006 May 11. FEBS Lett. 2006. PMID: 16712844 Free article.
CYP4A11, the major fatty acid omega-hydroxylase in human liver is involved in the balance of lipids, but its role and regulation are both poorly understood. ...Such a strong suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metab …
CYP4A11, the major fatty acid omega-hydroxylase in human liver is involved in the balance of lipids, but its role and regulation are …
Urothelial cancer gene regulatory networks inferred from large-scale RNAseq, Bead and Oligo gene expression data.
de Matos Simoes R, Dalleau S, Williamson KE, Emmert-Streib F. de Matos Simoes R, et al. BMC Syst Biol. 2015 May 14;9:21. doi: 10.1186/s12918-015-0165-z. BMC Syst Biol. 2015. PMID: 25971253 Free PMC article.
We investigated the structural and functional properties of GRNs for the identification of molecular targets associated to urothelial cancer. RESULTS: We found that the urothelial cancer (UC) GRNs show a significant enrichment of subnetworks that are associated with …
We investigated the structural and functional properties of GRNs for the identification of molecular targets associated to urothelial can …
Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity.
Quintanilha JCF, de Sousa VM, Visacri MB, Amaral LS, Santos RMM, Zambrano T, Salazar LA, Moriel P. Quintanilha JCF, et al. Cancer Chemother Pharmacol. 2017 Aug;80(2):223-233. doi: 10.1007/s00280-017-3358-x. Epub 2017 Jun 13. Cancer Chemother Pharmacol. 2017. PMID: 28612092 Review.
RESULTS: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2E1 and CYP4A11. The studies also suggested that the cisplatin and CYP2E1 interaction leads to the generation of reactive oxygen speci …
RESULTS: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2 …
Identification and analysis of prognostic metabolic characteristics in colon adenocarcinoma.
Yang Y, Yang X, Ren S, Cao Y, Wang Z, Cheng Z. Yang Y, et al. Heliyon. 2024 Mar 5;10(6):e27388. doi: 10.1016/j.heliyon.2024.e27388. eCollection 2024 Mar 30. Heliyon. 2024. PMID: 38509965 Free PMC article.
The five-year survival rate of metastatic colorectal cancer remains low, at 14 percent. Numerous publications have suggested a role for peroxisome proliferator-activated receptors (PPARs) in malignancy. ...Utilizing the differential expression profiles of stem cell-related …
The five-year survival rate of metastatic colorectal cancer remains low, at 14 percent. Numerous publications have suggested a role f …
Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications.
Jarrar YB, Lee SJ. Jarrar YB, et al. Int J Mol Sci. 2019 Aug 31;20(17):4274. doi: 10.3390/ijms20174274. Int J Mol Sci. 2019. PMID: 31480463 Free PMC article. Review.
As CYP4 enzymes play a role in the maintenance of fatty acids and fatty-acid-derived bioactive molecules within a normal range, they have been implicated in various biological functions, including inflammation, skin barrier, eye function, cardiovascular health, and cancer. …
As CYP4 enzymes play a role in the maintenance of fatty acids and fatty-acid-derived bioactive molecules within a normal range, they have be …
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney.
Imaoka S, Ogawa H, Kimura S, Gonzalez FJ. Imaoka S, et al. DNA Cell Biol. 1993 Dec;12(10):893-9. doi: 10.1089/dna.1993.12.893. DNA Cell Biol. 1993. PMID: 8274222
CYP4A11v is probably encoded by a rare allelic variant of CYP4A11, since no mutant alleles were uncovered in 15 normal individuals, as determined by a polymerase chain reaction (PCR) diagnostic test. Baculovirus-mediated cDNA expression of CYP4A11 yielded a P450 pro …
CYP4A11v is probably encoded by a rare allelic variant of CYP4A11, since no mutant alleles were uncovered in 15 normal individuals, a …
Cytochrome P450 4A11 expression in tumor cells: A favorable prognostic factor for hepatocellular carcinoma patients.
Eun HS, Cho SY, Lee BS, Kim S, Song IS, Chun K, Oh CH, Yeo MK, Kim SH, Kim KH. Eun HS, et al. J Gastroenterol Hepatol. 2019 Jan;34(1):224-233. doi: 10.1111/jgh.14406. Epub 2018 Aug 29. J Gastroenterol Hepatol. 2019. PMID: 30069903
The goal of this study was to evaluate the clinicopathological value of CYP4A11 expression in HCC. METHODS: We performed immunohistochemical analysis of CYP4A11 and correlated the results with clinicopathological features of HCC (n = 155). ...CONCLUSION: These findi …
The goal of this study was to evaluate the clinicopathological value of CYP4A11 expression in HCC. METHODS: We performed immunohistoc …
42 results