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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ. Yauch RL, et al. Among authors: callahan ca. Science. 2009 Oct 23;326(5952):572-4. doi: 10.1126/science.1179386. Epub 2009 Sep 2. Science. 2009. PMID: 19726788 Free PMC article.
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA. Rudin CM, et al. Among authors: callahan ca. N Engl J Med. 2009 Sep 17;361(12):1173-8. doi: 10.1056/NEJMoa0902903. Epub 2009 Sep 2. N Engl J Med. 2009. PMID: 19726761 Free PMC article.
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened.
Tang T, Tang JY, Li D, Reich M, Callahan CA, Fu L, Yauch RL, Wang F, Kotkow K, Chang KS, Shpall E, Wu A, Rubin LL, Marsters JC Jr, Epstein EH Jr, Caro I, de Sauvage FJ. Tang T, et al. Among authors: callahan ca. Clin Cancer Res. 2011 May 15;17(10):3378-87. doi: 10.1158/1078-0432.CCR-10-3370. Epub 2011 May 10. Clin Cancer Res. 2011. PMID: 21558397 Free PMC article. Clinical Trial.
Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.
Chen W, Tang T, Eastham-Anderson J, Dunlap D, Alicke B, Nannini M, Gould S, Yauch R, Modrusan Z, DuPree KJ, Darbonne WC, Plowman G, de Sauvage FJ, Callahan CA. Chen W, et al. Among authors: callahan ca. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9589-94. doi: 10.1073/pnas.1017945108. Epub 2011 May 19. Proc Natl Acad Sci U S A. 2011. PMID: 21597001 Free PMC article.
Therapeutic antibody targeting of individual Notch receptors.
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Wu Y, et al. Among authors: callahan ca. Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878. Nature. 2010. PMID: 20393564
Chronic DLL4 blockade induces vascular neoplasms.
Yan M, Callahan CA, Beyer JC, Allamneni KP, Zhang G, Ridgway JB, Niessen K, Plowman GD. Yan M, et al. Among authors: callahan ca. Nature. 2010 Feb 11;463(7282):E6-7. doi: 10.1038/nature08751. Nature. 2010. PMID: 20147986
Neuropilin-2 expression in cancer.
Jubb AM, Sa SM, Ratti N, Strickland LA, Schmidt M, Callahan CA, Koeppen H. Jubb AM, et al. Among authors: callahan ca. Histopathology. 2012 Sep;61(3):340-9. doi: 10.1111/j.1365-2559.2012.04224.x. Epub 2012 Mar 2. Histopathology. 2012. PMID: 22384800
Tau-beta-galactosidase, an axon-targeted fusion protein.
Callahan CA, Thomas JB. Callahan CA, et al. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5972-6. doi: 10.1073/pnas.91.13.5972. Proc Natl Acad Sci U S A. 1994. PMID: 8016099 Free PMC article.
40 results