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CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake.
Vivot K, Meszaros G, Pangou E, Zhang Z, Qu M, Erbs E, Yeghiazaryan G, Quiñones M, Grandgirard E, Schneider A, Clauss-Creusot E, Charlet A, Faour M, Martin C, Berditchevski F, Sumara I, Luquet S, Kloppenburg P, Nogueiras R, Ricci R. Vivot K, et al. Nat Metab. 2023 Jun;5(6):1045-1058. doi: 10.1038/s42255-023-00814-x. Epub 2023 Jun 5. Nat Metab. 2023. PMID: 37277610
Deletion of Camk1d in AgRP/NPY, but not in POMC, neurons is sufficient to recapitulate above phenotypes. ...Hence, CaMK1D links ghrelin action to transcriptional control of orexigenic neuropeptide availability in AgRP neurons....
Deletion of Camk1d in AgRP/NPY, but not in POMC, neurons is sufficient to recapitulate above phenotypes. ...Hence, CaMK1D link …
CAMK1D Inhibits Glioma Through the PI3K/AKT/mTOR Signaling Pathway.
Jin Q, Zhao J, Zhao Z, Zhang S, Sun Z, Shi Y, Yan H, Wang Y, Liu L, Zhao Z. Jin Q, et al. Front Oncol. 2022 Apr 13;12:845036. doi: 10.3389/fonc.2022.845036. eCollection 2022. Front Oncol. 2022. PMID: 35494053 Free PMC article.
Calcium/calmodulin-dependent protein ID (CAMK1D) is widely expressed in many tissues and involved in tumor cell growth. ...In the above experiments, the results of overexpression of CAMK1D were all contrary to those of knockdown. In terms of mechanism, this study fo …
Calcium/calmodulin-dependent protein ID (CAMK1D) is widely expressed in many tissues and involved in tumor cell growth. ...In the abo …
CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti-PD-L1 Treatment.
Volpin V, Michels T, Sorrentino A, Menevse AN, Knoll G, Ditz M, Milenkovic VM, Chen CY, Rathinasamy A, Griewank K, Boutros M, Haferkamp S, Berneburg M, Wetzel CH, Seckinger A, Hose D, Goldschmidt H, Ehrenschwender M, Witzens-Harig M, Szoor A, Vereb G, Khandelwal N, Beckhove P. Volpin V, et al. Cancer Immunol Res. 2020 Sep;8(9):1163-1179. doi: 10.1158/2326-6066.CIR-19-0608. Epub 2020 Jul 14. Cancer Immunol Res. 2020. PMID: 32665263
CAMK1D was activated by CTL through Fas-receptor stimulation, which led to CAMK1D binding to and phosphorylating caspase-3, -6, and -7, inhibiting their activation and function. Consistently, CAMK1D mediated immune resistance of murine colorectal cancer cells …
CAMK1D was activated by CTL through Fas-receptor stimulation, which led to CAMK1D binding to and phosphorylating caspase-3, -6 …
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
Xue A, Wu Y, Zhu Z, Zhang F, Kemper KE, Zheng Z, Yengo L, Lloyd-Jones LR, Sidorenko J, Wu Y; eQTLGen Consortium; McRae AF, Visscher PM, Zeng J, Yang J. Xue A, et al. Nat Commun. 2018 Jul 27;9(1):2941. doi: 10.1038/s41467-018-04951-w. Nat Commun. 2018. PMID: 30054458 Free PMC article.
A further integration of DNA methylation (n = 1980) and epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) with plausible regulatory mechanisms, whereby a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression. ...
A further integration of DNA methylation (n = 1980) and epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) w …
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.
Strausz S, Ruotsalainen S, Ollila HM, Karjalainen J, Kiiskinen T, Reeve M, Kurki M, Mars N, Havulinna AS, Luonsi E, Mansour Aly D, Ahlqvist E, Teder-Laving M, Palta P, Groop L, Mägi R, Mäkitie A, Salomaa V, Bachour A, Tuomi T; FinnGen; Palotie A, Palotie T, Ripatti S. Strausz S, et al. Eur Respir J. 2021 May 6;57(5):2003091. doi: 10.1183/13993003.03091-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33243845 Free article.
We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We conducted the first large-scale genome-wide association study of OSA using the FinnGen study (217 955 individuals) with 16 761 OSA patients id …
We aimed to identify genetic loci associated with OSA risk, and to test if OSA and its comorbidities share a common genetic background.We co …
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer.
Bergamaschi A, Kim YH, Kwei KA, La Choi Y, Bocanegra M, Langerød A, Han W, Noh DY, Huntsman DG, Jeffrey SS, Børresen-Dale AL, Pollack JR. Bergamaschi A, et al. Mol Oncol. 2008 Dec;2(4):327-39. doi: 10.1016/j.molonc.2008.09.004. Epub 2008 Oct 2. Mol Oncol. 2008. PMID: 19383354 Free PMC article.
By microarray, CAMK1D was overexpressed when amplified, and by immunohistochemistry exhibited elevated expression in invasive carcinomas compared to carcinoma in situ. ...Our findings identify CAMK1D as a novel amplified oncogene linked to EMT in breast cancer, and …
By microarray, CAMK1D was overexpressed when amplified, and by immunohistochemistry exhibited elevated expression in invasive carcino …
Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.
Du B, Jia X, Tian W, Yan X, Wang N, Cai D, Li X, Zhang H, Jin M, Wu N, Qiu C, Zhang Q. Du B, et al. J Diabetes Complications. 2021 Jan;35(1):107752. doi: 10.1016/j.jdiacomp.2020.107752. Epub 2020 Oct 7. J Diabetes Complications. 2021. PMID: 33127268
To investigate the association of common single-nucleotide polymorphisms (SNPs) of SUCNR1, GRK4 and CAMK1D genes with the susceptibility of the two diseases in a northern Chinese Han population. ...CONCLUSION: To the best of our knowledge, the present study is the first to …
To investigate the association of common single-nucleotide polymorphisms (SNPs) of SUCNR1, GRK4 and CAMK1D genes with the susceptibil …
Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer's Disease.
Grant P, Kumar J, Kar S, Overduin M. Grant P, et al. Molecules. 2021 Dec 18;26(24):7669. doi: 10.3390/molecules26247669. Molecules. 2021. PMID: 34946752 Free PMC article.
Here, we examine the effects of two specific kinase inhibitors for calcium/calmodulin-dependent protein kinase type 1D (CaMK1D) on Abeta-mediated toxicity, using mouse primary cortical neurons. ...
Here, we examine the effects of two specific kinase inhibitors for calcium/calmodulin-dependent protein kinase type 1D (CaMK1D) on Ab …
LncRNA ILF3-AS1 Promotes the Progression of Colon Adenocarcinoma Cells Through the miR-619-5p/CAMK1D Axis.
Liu W, Li S. Liu W, et al. Onco Targets Ther. 2021 Mar 12;14:1861-1872. doi: 10.2147/OTT.S296441. eCollection 2021. Onco Targets Ther. 2021. PMID: 33737811 Free PMC article.
The effects of ILF3-AS1 on cell proliferation, migration, invasion and apoptosis were measured by CCK-8 assay, transwell migration and invasion assay, and flow cytometry apoptosis assay, respectively. The direct binding of ILF3-AS1 and miR-619-5p/CAMK1D was validated by th …
The effects of ILF3-AS1 on cell proliferation, migration, invasion and apoptosis were measured by CCK-8 assay, transwell migration and invas …
98 results