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The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis.
Filomeni G, Piccirillo S, Graziani I, Cardaci S, Da Costa Ferreira AM, Rotilio G, Ciriolo MR. Filomeni G, et al. Among authors: cardaci s. Carcinogenesis. 2009 Jul;30(7):1115-24. doi: 10.1093/carcin/bgp105. Epub 2009 Apr 30. Carcinogenesis. 2009. PMID: 19406932 Free PMC article.
Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment.
Filomeni G, Cardaci S, Da Costa Ferreira AM, Rotilio G, Ciriolo MR. Filomeni G, et al. Among authors: cardaci s. Biochem J. 2011 Aug 1;437(3):443-53. doi: 10.1042/BJ20110510. Biochem J. 2011. PMID: 21548882
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