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Showing results for charlie long
Search for Carlie Long instead (1 results)
The metabolic basis of epilepsy.
Rho JM, Boison D. Rho JM, et al. Nat Rev Neurol. 2022 Jun;18(6):333-347. doi: 10.1038/s41582-022-00651-8. Epub 2022 Mar 31. Nat Rev Neurol. 2022. PMID: 35361967 Free PMC article. Review.
The brain is a highly energy-demanding organ and requires bioenergetic adaptability to balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures, the hallmark feature of the epilepsies. Recurrent or prolonged seizures have long been known t …
The brain is a highly energy-demanding organ and requires bioenergetic adaptability to balance normal activity with pathophysiological fuell …
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
DiSilvestro P, Banerjee S, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Oza A, González-Martín A, Aghajanian C, Bradley W, Mathews C, Liu J, McNamara J, Lowe ES, Ah-See ML, Moore KN; SOLO1 Investigators. DiSilvestro P, et al. J Clin Oncol. 2023 Jan 20;41(3):609-617. doi: 10.1200/JCO.22.01549. Epub 2022 Sep 9. J Clin Oncol. 2023. PMID: 36082969 Free PMC article. Clinical Trial.
CONCLUSION: Results indicate a clinically meaningful, albeit not statistically significant according to prespecified criteria, improvement in OS with maintenance olaparib in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation and support the use of maintenan …
CONCLUSION: Results indicate a clinically meaningful, albeit not statistically significant according to prespecified criteria, improvement i …
The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.
Fu Y, Xiang Y, Wang Y, Liu Z, Yang D, Zha J, Tang C, Cai J, Chen G, Dong Z. Fu Y, et al. Theranostics. 2023 May 8;13(9):2757-2773. doi: 10.7150/thno.81406. eCollection 2023. Theranostics. 2023. PMID: 37284446 Free PMC article.
While RLDC reduces acute nephrotoxicity to certain extents, a significant portion of patients later develop chronic kidney problems, underscoring the need for novel therapeutics to alleviate the long-term sequelae of RLDC therapy. Methods: In vivo, the role of HMGB1 was ex …
While RLDC reduces acute nephrotoxicity to certain extents, a significant portion of patients later develop chronic kidney problems, undersc …
A proinflammatory long noncoding RNA Lncenc1 regulates inflammasome activation in macrophage.
Han Y, Zhu Y, Dutta S, Almuntashiri S, Wang X, Zhang D. Han Y, et al. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L584-L595. doi: 10.1152/ajplung.00056.2022. Epub 2023 Mar 7. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36880658
Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs). LncRNAs are extensively expressed in various immune cells. ...However, very little research has been conducted to explore how they alter innate immune responses during host-pathogen interactions. In this …
Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs). LncRNAs are extensively expressed in various immune cells. ...Ho …
Long-term glucocorticoid exposure persistently impairs CD4+ T cell biology by epigenetically modulating the mTORC1 pathway.
Chen H, Tan C, Wang Z, Zha J, Liu H, Dong Z, Chen G. Chen H, et al. Biochem Pharmacol. 2023 May;211:115503. doi: 10.1016/j.bcp.2023.115503. Epub 2023 Mar 15. Biochem Pharmacol. 2023. PMID: 36924904
Conventional glucocorticoid (GC) treatment has a long-term influence on T-cell immunity, resulting in an increased risk of opportunistic infection after drug withdrawal. The underlying mechanisms remain ambiguous. This study demonstrated that long-term GC treatment …
Conventional glucocorticoid (GC) treatment has a long-term influence on T-cell immunity, resulting in an increased risk of opportunis …
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.
Aregger M, Lawson KA, Billmann M, Costanzo M, Tong AHY, Chan K, Rahman M, Brown KR, Ross C, Usaj M, Nedyalkova L, Sizova O, Habsid A, Pawling J, Lin ZY, Abdouni H, Wong CJ, Weiss A, Mero P, Dennis JW, Gingras AC, Myers CL, Andrews BJ, Boone C, Moffat J. Aregger M, et al. Nat Metab. 2020 Jun;2(6):499-513. doi: 10.1038/s42255-020-0211-z. Epub 2020 Jun 1. Nat Metab. 2020. PMID: 32694731 Free PMC article.
Here, we use pooled genome-wide CRISPR screens to systematically map genetic interactions (GIs) in human HAP1 cells carrying a loss-of-function mutation in fatty acid synthase (FASN), whose product catalyses the formation of long-chain fatty acids. FASN-mutant cells show a …
Here, we use pooled genome-wide CRISPR screens to systematically map genetic interactions (GIs) in human HAP1 cells carrying a loss-of-funct …
Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury.
Dutta S, Zhu Y, Han Y, Almuntashiri S, Wang X, Zhang D. Dutta S, et al. J Clin Med. 2023 Jan 11;12(2):604. doi: 10.3390/jcm12020604. J Clin Med. 2023. PMID: 36675533 Free PMC article. Review.
Due to the involvement of multiple factors, the pathogenesis of ALI is complex and is not fully understood yet. Long noncoding RNAs (lncRNAs) are a group of non-protein-coding transcripts longer than 200 nucleotides. ...
Due to the involvement of multiple factors, the pathogenesis of ALI is complex and is not fully understood yet. Long noncoding RNAs ( …
Two-way communication between the nucleus and mitochondria via a micropeptide in renal fibrosis.
Cai J, Dong Z. Cai J, et al. Kidney Int. 2023 May;103(5):833-835. doi: 10.1016/j.kint.2023.02.009. Kidney Int. 2023. PMID: 37085255
Micropeptides are small proteins encoded by short open reading frames mostly located in long noncoding RNAs. Mitoregulin (MOXI) is a nuclear encoded micropeptide initially identified in the inner mitochondrial membrane to regulate fatty acid beta-oxidation. ...
Micropeptides are small proteins encoded by short open reading frames mostly located in long noncoding RNAs. Mitoregulin (MOXI) is a …
Travels with Charlie.
Best JB. Best JB. Med J Aust. 2015 Nov 2;203(9):373-4. doi: 10.5694/mja15.00916. Med J Aust. 2015. PMID: 26510811
Playing woodwind instruments has long been shown to assist those with asthma; now playing the didgeridoo is also found to help....
Playing woodwind instruments has long been shown to assist those with asthma; now playing the didgeridoo is also found to help....
150 results