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Risk of Myopathy in Patients in Therapy with Statins: Identification of Biological Markers in a Pilot Study.
Camerino GM, Musumeci O, Conte E, Musaraj K, Fonzino A, Barca E, Marino M, Rodolico C, Tricarico D, Camerino C, Carratù MR, Desaphy JF, De Luca A, Toscano A, Pierno S. Camerino GM, et al. Among authors: carratu mr. Front Pharmacol. 2017 Jul 27;8:500. doi: 10.3389/fphar.2017.00500. eCollection 2017. Front Pharmacol. 2017. PMID: 28798690 Free PMC article.
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.
Desaphy JF, Farinato A, Altamura C, De Bellis M, Imbrici P, Tarantino N, Caccia C, Melloni E, Padoani G, Vailati S, Keywood C, Carratù MR, De Luca A, Conte D, Pierno S. Desaphy JF, et al. Among authors: carratu mr. Exp Neurol. 2020 Jun;328:113287. doi: 10.1016/j.expneurol.2020.113287. Epub 2020 Mar 20. Exp Neurol. 2020. PMID: 32205118
Target Mutation-Driven Drug Discovery.
Altamura C, Conte D, Carratù MR, Desaphy JF. Altamura C, et al. Among authors: carratu mr. Curr Med Chem. 2022 Aug 15;29(31):5156-5158. doi: 10.2174/1389450123666220418111200. Curr Med Chem. 2022. PMID: 35440295 No abstract available.
The analysis of myotonia congenita mutations discloses functional clusters of amino acids within the CBS2 domain and the C-terminal peptide of the ClC-1 channel.
Altamura C, Lucchiari S, Sahbani D, Ulzi G, Comi GP, D'Ambrosio P, Petillo R, Politano L, Vercelli L, Mongini T, Dotti MT, Cardani R, Meola G, Lo Monaco M, Matthews E, Hanna MG, Carratù MR, Conte D, Imbrici P, Desaphy JF. Altamura C, et al. Among authors: carratu mr. Hum Mutat. 2018 Sep;39(9):1273-1283. doi: 10.1002/humu.23581. Epub 2018 Jul 4. Hum Mutat. 2018. PMID: 29935101 Free article.
Mapping ligand binding pockets in chloride ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid.
Altamura C, Mangiatordi GF, Nicolotti O, Sahbani D, Farinato A, Leonetti F, Carratù MR, Conte D, Desaphy JF, Imbrici P. Altamura C, et al. Among authors: carratu mr. Br J Pharmacol. 2018 May;175(10):1770-1780. doi: 10.1111/bph.14192. Epub 2018 Apr 6. Br J Pharmacol. 2018. PMID: 29500929 Free PMC article.
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.
De Bellis M, Carbonara R, Roussel J, Farinato A, Massari A, Pierno S, Muraglia M, Corbo F, Franchini C, Carratù MR, De Luca A, Conte Camerino D, Desaphy JF. De Bellis M, et al. Among authors: carratu mr. Neuropharmacology. 2017 Feb;113(Pt A):206-216. doi: 10.1016/j.neuropharm.2016.10.013. Epub 2016 Oct 13. Neuropharmacology. 2017. PMID: 27743929 Free PMC article.
97 results