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Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.
Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Laprévote O, Bièche I, Auzeil N, Potier MC, Dutar P, Korte M, Buée L, Blum D, Cartier N. Burlot MA, et al. Among authors: cartier n. Hum Mol Genet. 2015 Nov 1;24(21):5965-76. doi: 10.1093/hmg/ddv268. Epub 2015 Sep 10. Hum Mol Genet. 2015. PMID: 26358780
CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease.
Djelti F, Braudeau J, Hudry E, Dhenain M, Varin J, Bièche I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P, Cartier N. Djelti F, et al. Among authors: cartier n. Brain. 2015 Aug;138(Pt 8):2383-98. doi: 10.1093/brain/awv166. Epub 2015 Jul 2. Brain. 2015. PMID: 26141492
Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.
Audrain M, Fol R, Dutar P, Potier B, Billard JM, Flament J, Alves S, Burlot MA, Dufayet-Chaffaud G, Bemelmans AP, Valette J, Hantraye P, Déglon N, Cartier N, Braudeau J. Audrain M, et al. Among authors: cartier n. Mol Neurodegener. 2016 Jan 12;11:5. doi: 10.1186/s13024-016-0070-y. Mol Neurodegener. 2016. PMID: 26759118 Free PMC article.
Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis.
Ayciriex S, Djelti F, Alves S, Regazzetti A, Gaudin M, Varin J, Langui D, Bièche I, Hudry E, Dargère D, Aubourg P, Auzeil N, Laprévote O, Cartier N. Ayciriex S, et al. Among authors: cartier n. Front Mol Neurosci. 2017 Jul 11;10:211. doi: 10.3389/fnmol.2017.00211. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28744197 Free PMC article.
βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.
Audrain M, Souchet B, Alves S, Fol R, Viode A, Haddjeri A, Tada S, Orefice NS, Joséphine C, Bemelmans AP, Delzescaux T, Déglon N, Hantraye P, Akwa Y, Becher F, Billard JM, Potier B, Dutar P, Cartier N, Braudeau J. Audrain M, et al. Among authors: cartier n. Cereb Cortex. 2018 Nov 1;28(11):3976-3993. doi: 10.1093/cercor/bhx260. Cereb Cortex. 2018. PMID: 29048465
Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.
Marquer C, Laine J, Dauphinot L, Hanbouch L, Lemercier-Neuillet C, Pierrot N, Bossers K, Le M, Corlier F, Benstaali C, Saudou F, Thinakaran G, Cartier N, Octave JN, Duyckaerts C, Potier MC. Marquer C, et al. Among authors: cartier n. Mol Neurodegener. 2014 Dec 18;9:60. doi: 10.1186/1750-1326-9-60. Mol Neurodegener. 2014. PMID: 25524049 Free PMC article.
93 results