Carvalho I - Search Results

1

From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.

Chierrito TPC, Pedersoli-Mantoani S, Roca C, Requena C, Sebastian-Perez V, Castillo WO, Moreira NCS, Pérez C, Sakamoto-Hojo ET, Takahashi CS, Jiménez-Barbero J, Cañada FJ, Campillo NE, Martinez A, Carvalho I. Chierrito TPC, et al. Among authors: carvalho i. Eur J Med Chem. 2017 Oct 20;139:773-791. doi: 10.1016/j.ejmech.2017.08.051. Epub 2017 Aug 26. Eur J Med Chem. 2017. PMID: 28863358

2

Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease.

da Silva CH, Campo VL, Carvalho I, Taft CA. da Silva CH, et al. Among authors: carvalho i. J Mol Graph Model. 2006 Oct;25(2):169-75. doi: 10.1016/j.jmgm.2005.12.002. Epub 2006 Jan 18. J Mol Graph Model. 2006. PMID: 16413803

3

'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase.

Carvalho I, Andrade P, Campo VL, Guedes PM, Sesti-Costa R, Silva JS, Schenkman S, Dedola S, Hill L, Rejzek M, Nepogodiev SA, Field RA. Carvalho I, et al. Bioorg Med Chem. 2010 Apr 1;18(7):2412-27. doi: 10.1016/j.bmc.2010.02.053. Epub 2010 Mar 2. Bioorg Med Chem. 2010. PMID: 20335038 Free article.

4

In silico design and search for acetylcholinesterase inhibitors in Alzheimer's disease with a suitable pharmacokinetic profile and low toxicity.

da Silva VB, de Andrade P, Kawano DF, Morais PA, de Almeida JR, Carvalho I, Taft CA, da Silva CH. da Silva VB, et al. Among authors: carvalho i. Future Med Chem. 2011 Jun;3(8):947-60. doi: 10.4155/fmc.11.67. Future Med Chem. 2011. PMID: 21707398 Review.

5

α-Selective glycosylation affords mucin-related GalNAc amino acids and diketopiperazines active on Trypanosoma cruzi.

Martins-Teixeira MB, Campo VL, Biondo M, Sesti-Costa R, Carneiro ZA, Silva JS, Carvalho I. Martins-Teixeira MB, et al. Among authors: carvalho i. Bioorg Med Chem. 2013 Apr 1;21(7):1978-87. doi: 10.1016/j.bmc.2013.01.027. Epub 2013 Feb 8. Bioorg Med Chem. 2013. PMID: 23415086 Free article.

6

Design, synthesis and enzymatic evaluation of 3-O-substituted aryl β-D-galactopyranosides as inhibitors of Trypanosoma cruzi trans-sialidase.

Silva BL, S Filho JD, Andrade P, Carvalho I, Alves RJ. Silva BL, et al. Among authors: carvalho i. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4529-4532. doi: 10.1016/j.bmcl.2014.07.088. Epub 2014 Aug 7. Bioorg Med Chem Lett. 2014. PMID: 25149510

7

1,2,3-Triazole-based analogue of benznidazole displays remarkable activity against Trypanosoma cruzi.

de Andrade P, Galo OA, Carvalho MR, Lopes CD, Carneiro ZA, Sesti-Costa R, de Melo EB, Silva JS, Carvalho I. de Andrade P, et al. Among authors: carvalho mr, carvalho i. Bioorg Med Chem. 2015 Nov 1;23(21):6815-26. doi: 10.1016/j.bmc.2015.10.008. Epub 2015 Oct 9. Bioorg Med Chem. 2015. PMID: 26476667

8

Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.

Mantoani SP, Chierrito TP, Vilela AF, Cardoso CL, Martínez A, Carvalho I. Mantoani SP, et al. Among authors: carvalho i. Molecules. 2016 Feb 5;21(2):193. doi: 10.3390/molecules21020193. Molecules. 2016. PMID: 26861273 Free PMC article.

9

Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.

Hartmann AP, de Carvalho MR, Bernardes LSC, Moraes MH, de Melo EB, Lopes CD, Steindel M, da Silva JS, Carvalho I. Hartmann AP, et al. Among authors: carvalho i. Eur J Med Chem. 2017 Nov 10;140:187-199. doi: 10.1016/j.ejmech.2017.08.064. Epub 2017 Sep 4. Eur J Med Chem. 2017. PMID: 28926763

10

Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion.

Marchiori MF, Riul TB, Oliveira Bortot L, Andrade P, Junqueira GG, Foca G, Doti N, Ruvo M, Dias-Baruffi M, Carvalho I, Campo VL. Marchiori MF, et al. Among authors: carvalho i. Bioorg Med Chem. 2017 Nov 1;25(21):6049-6059. doi: 10.1016/j.bmc.2017.09.042. Epub 2017 Sep 30. Bioorg Med Chem. 2017. PMID: 29032929

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