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CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR.
Bapat J, Yamamoto TM, Woodruff ER, Qamar L, Mikeska RG, Aird KM, Watson ZL, Brubaker LW, Bitler BG. Bapat J, et al. Cancer Gene Ther. 2024 Feb;31(2):300-310. doi: 10.1038/s41417-023-00703-1. Epub 2023 Nov 29. Cancer Gene Ther. 2024. PMID: 38030811 Free PMC article.
Most anoikis resistant mechanisms are dependent on microenvironment interactions with cell surface-associated proteins, such as integrins and receptor tyrosine kinases (RTKs). We previously identified the gene CASC4 as a driver of anoikis resistance. CASC4 is predic …
Most anoikis resistant mechanisms are dependent on microenvironment interactions with cell surface-associated proteins, such as integrins an …
Tn antigen promotes breast cancer metastasis via impairment of CASC4.
Li R, Dong X, Chen S, Tan J, Chen X, Liu J, Wen T, Ru X. Li R, et al. Cell Biol Int. 2023 Nov;47(11):1854-1867. doi: 10.1002/cbin.12077. Epub 2023 Jul 26. Cell Biol Int. 2023. PMID: 37493437
Overexpression of CASC4 suppressed Tn-induced activation of EMT and cancer metastasis via inhibition of Cdc42 signaling. Furthermore, we confirmed that O-glycosylation is essential for the functional role of CASC4 because defective O-glycosylated CASC4 (mutan …
Overexpression of CASC4 suppressed Tn-induced activation of EMT and cancer metastasis via inhibition of Cdc42 signaling. Furthermore, …
SRSF1-Regulated Alternative Splicing in Breast Cancer.
Anczuków O, Akerman M, Cléry A, Wu J, Shen C, Shirole NH, Raimer A, Sun S, Jensen MA, Hua Y, Allain FH, Krainer AR. Anczuków O, et al. Mol Cell. 2015 Oct 1;60(1):105-17. doi: 10.1016/j.molcel.2015.09.005. Mol Cell. 2015. PMID: 26431027 Free PMC article.
Finally, we identified SRSF1-regulated AS events deregulated in human tumors; overexpressing one such isoform, exon-9-included CASC4, increased acinar size and proliferation, and decreased apoptosis, partially recapitulating SRSF1's oncogenic effects. ...
Finally, we identified SRSF1-regulated AS events deregulated in human tumors; overexpressing one such isoform, exon-9-included CASC4, …
Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression.
Duval S, Abu-Thuraia A, Elkholi IE, Chen R, Seebun D, Mayne J, Côté JF, Figeys D, Seidah NG. Duval S, et al. Cell Death Dis. 2020 Aug 20;11(8):665. doi: 10.1038/s41419-020-02893-0. Cell Death Dis. 2020. PMID: 32820145 Free PMC article.
Our data unraveled a cancer-protective role for CASC4, because siRNA silencing of endogenous CASC4 expression in the invasive triple-negative breast cancer human cell line MDA-MB-231 resulted in a significantly increased cellular migration and invasion. ...This phen …
Our data unraveled a cancer-protective role for CASC4, because siRNA silencing of endogenous CASC4 expression in the invasive …
Alternative splicing in osteoclasts and Paget's disease of bone.
Klinck R, Laberge G, Bisson M, McManus S, Michou L, Brown JP, Roux S. Klinck R, et al. BMC Med Genet. 2014 Aug 14;15:98. doi: 10.1186/s12881-014-0098-1. BMC Med Genet. 2014. PMID: 25115182 Free PMC article.
RESULTS: This analysis led to the identification of six AS events significantly associated with PDB, but none with p62P392L. The corresponding genes included LGALS8, RHOT1, CASC4, USP4, TBC1D25, and PIDD. In addition, RHOT1 and LGALS8 genes were upregulated in pagetic OCs, …
RESULTS: This analysis led to the identification of six AS events significantly associated with PDB, but none with p62P392L. The correspondi …
Computer Analysis of Glioma Transcriptome Profiling: Alternative Splicing Events.
Babenko VN, Gubanova NV, Bragin AO, Chadaeva IV, Vasiliev GV, Medvedeva IV, Gaytan AS, Krivoshapkin AL, Orlov YL. Babenko VN, et al. J Integr Bioinform. 2017 Sep 18;14(3):20170022. doi: 10.1515/jib-2017-0022. J Integr Bioinform. 2017. PMID: 28918420 Free PMC article.
Three cancer-associated genes were considered in detail, in particular: APP (amyloid beta precursor protein), CASC4 (cancer susceptibility candidate 4) and TP53. Such alternative splicing opens new perspectives for cancer research....
Three cancer-associated genes were considered in detail, in particular: APP (amyloid beta precursor protein), CASC4 (cancer susceptib …
The Hydroxyproline Proteome of HeLa Cells with Emphasis on the Active Sites of Protein Disulfide Isomerases.
Onisko BC. Onisko BC. J Proteome Res. 2020 Feb 7;19(2):756-768. doi: 10.1021/acs.jproteome.9b00625. Epub 2020 Jan 23. J Proteome Res. 2020. PMID: 31927932
Fifteen of the sites most likely contain 4R-hydroxyproline (Pro30 of serpin H1, Pro520 of aspartyl/asparaginyl beta-hydroxylase, Pro223 of neutral alpha-glucosidase AB, Pro977 of hypoxia upregulated protein 1, Pro378 of protein ERGIC-53, Pro252 of protein CASC4, Pro545 of …
Fifteen of the sites most likely contain 4R-hydroxyproline (Pro30 of serpin H1, Pro520 of aspartyl/asparaginyl beta-hydroxylase, Pro223 of n …
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
Wang KS, Liu X, Zhang Q, Pan Y, Aragam N, Zeng M. Wang KS, et al. J Psychiatr Res. 2011 Nov;45(11):1419-25. doi: 10.1016/j.jpsychires.2011.06.005. Epub 2011 Jun 24. J Psychiatr Res. 2011. PMID: 21703634
The top hit of PKNOX2 (rs750338 with p=1.47 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol …
The top hit of PKNOX2 (rs750338 with p=1.47 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 familie …
Identification of Differentially Expressed Gene Transcripts in Porcine Endometrium during Early Stages of Pregnancy.
Pierzchała M, Pierzchała D, Ogłuszka M, Poławska E, Blicharski T, Roszczyk A, Nawrocka A, Urbański P, Stepanow K, Ciepłoch A, Korwin-Kossakowska A, Pas MFWT, Slaska B, Buszewska-Forajta M, Jaśkowski JM, Sachajko M, Herudzińska M, Jaśkowski BM, Niżański W, Fraser L, Czarnik U, Kadarmideen HN, Pareek CS. Pierzchała M, et al. Life (Basel). 2020 May 16;10(5):68. doi: 10.3390/life10050068. Life (Basel). 2020. PMID: 32429378 Free PMC article.

Moreover, blastn comparison of microarray-probes sequences against sus-scrofa11 assembly identified commonly shared upregulated endometrial DEG-transcript-probes (E < 0.06; >2 FC), that were regulating the gene functions of reproduction and growth (SELENOP), cytoskeleton or

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Moreover, blastn comparison of microarray-probes sequences against sus-scrofa11 assembly identified commonly shared upregulated endometrial …