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2,945 results

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Amphiregulin induces CCN2 and fibronectin expression by TGF-beta through EGFR-dependent pathway in lung epithelial cells.
Cheng WH, Kao SY, Chen CL, Yuliani FS, Lin LY, Lin CH, Chen BC. Cheng WH, et al. Respir Res. 2022 Dec 28;23(1):381. doi: 10.1186/s12931-022-02285-2. Respir Res. 2022. PMID: 36578010 Free PMC article.
However, whether AREG is involved in TGF-beta-induced CCN2 and FN expression in human lung epithelial cells is unknown. ...AREG small interfering (si) RNA inhibited TGF-beta-induced expression of CCN2, FN, and cell migration. Furthermore, AREG-induced CCN2 an …
However, whether AREG is involved in TGF-beta-induced CCN2 and FN expression in human lung epithelial cells is unknown. ...AREG small …
Roles of CCN2 as a mechano-sensing regulator of chondrocyte differentiation.
Nishida T, Kubota S. Nishida T, et al. Jpn Dent Sci Rev. 2020 Nov;56(1):119-126. doi: 10.1016/j.jdsr.2020.07.001. Epub 2020 Oct 9. Jpn Dent Sci Rev. 2020. PMID: 33088364 Free PMC article. Review.
Of note, CCN2 behaves like a biomarker to sense suitable mechanical stress, because CCN2 expression is down-regulated when chondrocytes are subjected to excessive mechanical stress. ...This review summarizes the characterization of mechanoreceptors involved in CC …
Of note, CCN2 behaves like a biomarker to sense suitable mechanical stress, because CCN2 expression is down-regulated when cho …
CTGF/CCN2 from Skeletal Muscle to Nervous System: Impact on Neurodegenerative Diseases.
Gonzalez D, Brandan E. Gonzalez D, et al. Mol Neurobiol. 2019 Aug;56(8):5911-5916. doi: 10.1007/s12035-019-1490-9. Epub 2019 Jan 28. Mol Neurobiol. 2019. PMID: 30689195 Review.
Connective tissue growth factor (CTGF/CCN2) is a matricellular protein that belongs to the CCN family of proteins. ...Recently, it has been shown that skeletal muscle of symptomatic hSOD1(G93A) mice, a model for Amyotrophic lateral sclerosis (ALS), shows up-regulation of C …
Connective tissue growth factor (CTGF/CCN2) is a matricellular protein that belongs to the CCN family of proteins. ...Recently, it ha …
CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis.
Leguit RJ, Raymakers RAP, Hebeda KM, Goldschmeding R. Leguit RJ, et al. J Cell Commun Signal. 2021 Mar;15(1):25-56. doi: 10.1007/s12079-020-00602-2. Epub 2021 Jan 11. J Cell Commun Signal. 2021. PMID: 33428075 Free PMC article. Review.
In the bone marrow (BM), CCN2 is highly expressed in mesenchymal stem/stromal cells (MSCs). CCN2 is important for MSC function, supporting its proliferation, migration and differentiation. ...
In the bone marrow (BM), CCN2 is highly expressed in mesenchymal stem/stromal cells (MSCs). CCN2 is important for MSC function …
CCN2 participates in overload-induced skeletal muscle hypertrophy.
Petrosino JM, Longenecker JZ, Angell CD, Hinger SA, Martens CR, Accornero F. Petrosino JM, et al. Matrix Biol. 2022 Feb;106:1-11. doi: 10.1016/j.matbio.2022.01.003. Epub 2022 Jan 16. Matrix Biol. 2022. PMID: 35045313 Free PMC article.
To elucidate the role of CCN2 in mediating the hypertrophic response, we utilized genetically engineered mouse models for myofiber-specific CCN2 gain- and loss-of-function and then examined their response to mechanical stimuli through muscle overload. ...On the othe …
To elucidate the role of CCN2 in mediating the hypertrophic response, we utilized genetically engineered mouse models for myofiber-sp …
Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin-Yang Collaboration.
Kubota S, Kawata K, Hattori T, Nishida T. Kubota S, et al. Int J Mol Sci. 2022 May 24;23(11):5887. doi: 10.3390/ijms23115887. Int J Mol Sci. 2022. PMID: 35682564 Free PMC article. Review.
Despite their striking structural similarities, these two members show contrastive molecular functions as well as temporospatial emergence in living tissues. Typically, CCN2 promotes cell growth, whereas CCN3 restrains it. Where CCN2 is produced, CCN3 disappears. .. …
Despite their striking structural similarities, these two members show contrastive molecular functions as well as temporospatial emergence i …
CCN2 Binds to Tubular Epithelial Cells in the Kidney.
Rayego-Mateos S, Morgado-Pascual JL, Lavoz C, Rodrigues-Díez RR, Márquez-Expósito L, Tejera-Muñoz A, Tejedor-Santamaría L, Rubio-Soto I, Marchant V, Ruiz-Ortega M. Rayego-Mateos S, et al. Biomolecules. 2022 Feb 3;12(2):252. doi: 10.3390/biom12020252. Biomolecules. 2022. PMID: 35204752 Free PMC article.
Previous experiments using surface plasmon resonance and cultured renal cells have demonstrated that the C-terminal module of CCN2 (CCN2(IV)) interacts with the epidermal growth factor receptor (EGFR). ...In conclusion, these studies show that circulating CCN2 …
Previous experiments using surface plasmon resonance and cultured renal cells have demonstrated that the C-terminal module of CCN2 ( …
CCN2 Activates RIPK3, NLRP3 Inflammasome, and NRF2/Oxidative Pathways Linked to Kidney Inflammation.
Rayego-Mateos S, Marquez-Exposito L, Basantes P, Tejedor-Santamaria L, Sanz AB, Nguyen TQ, Goldschmeding R, Ortiz A, Ruiz-Ortega M. Rayego-Mateos S, et al. Antioxidants (Basel). 2023 Jul 31;12(8):1541. doi: 10.3390/antiox12081541. Antioxidants (Basel). 2023. PMID: 37627536 Free PMC article.
CCN2 was shown to be involved in kidney damage through the regulation of proinflammatory and profibrotic responses. ...RIPK3 deficiency diminished the CCN2-induced renal upregulation of proinflammatory mediators and prevented NLRP3 modulation. ...
CCN2 was shown to be involved in kidney damage through the regulation of proinflammatory and profibrotic responses. ...RIPK3 deficien …
CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development.
Wang Y, Liu X, Xu Q, Xu W, Zhou X, Leask A, Lin Z. Wang Y, et al. JCI Insight. 2023 Jan 10;8(1):e162987. doi: 10.1172/jci.insight.162987. JCI Insight. 2023. PMID: 36625347 Free PMC article.
Mechanistically, our findings reveal that CCN2 intersects with TGF-beta signaling and regulates SMC marker expression. ...These results identify SMC-CCN2 as potentially a novel regulator of SMC phenotypic switching and AA biology....
Mechanistically, our findings reveal that CCN2 intersects with TGF-beta signaling and regulates SMC marker expression. ...These resul …
CCN2/CTGF-A Modulator of the Optic Nerve Head Astrocyte.
Dillinger AE, Weber GR, Mayer M, Schneider M, Göppner C, Ohlmann A, Shamonin M, Monkman GJ, Fuchshofer R. Dillinger AE, et al. Front Cell Dev Biol. 2022 Apr 14;10:864433. doi: 10.3389/fcell.2022.864433. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35493079 Free PMC article.
In this study we wanted to get a better understanding of the function of CCN2/CTGF under normal and pathologic conditions. To this end, we analyzed the glial lamina and peripapillary sclera of CCN2/CTGF overexpressing mice and studied the effect of CCN2/CTGF …
In this study we wanted to get a better understanding of the function of CCN2/CTGF under normal and pathologic conditions. To this en …
2,945 results