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Year Number of Results
1984 1
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1999 34
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2,938 results

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Page 1
Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B.
Gao Y, You M, Fu J, Tian M, Zhong X, Du C, Hong Z, Zhu Z, Liu J, Markowitz GJ, Wang FS, Yang P. Gao Y, et al. J Hepatol. 2022 Jan;76(1):148-159. doi: 10.1016/j.jhep.2021.08.029. Epub 2021 Sep 12. J Hepatol. 2022. PMID: 34689996
To block CCR4(+) Treg chemotaxis, we developed an N-terminus recombinant protein of CCR4 (N-CCR4-Fc) as a neutralizing pseudo-receptor that effectively bound to its ligand CCL22. ...Compared with CCR4(-) Tregs, CCR4(+) Tregs exhibited increased …
To block CCR4(+) Treg chemotaxis, we developed an N-terminus recombinant protein of CCR4 (N-CCR4-Fc) as a neutralizing …
CCR4 as a Therapeutic Target for Cancer Immunotherapy.
Yoshie O. Yoshie O. Cancers (Basel). 2021 Nov 4;13(21):5542. doi: 10.3390/cancers13215542. Cancers (Basel). 2021. PMID: 34771703 Free PMC article. Review.
CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was described as highly selective for helper T type 2 (Th2) cells. ...
CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originall …
Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma.
Watanabe K, Gomez AM, Kuramitsu S, Siurala M, Da T, Agarwal S, Song D, Scholler J, Rotolo A, Posey AD, Rook AH, Haun PL, Ruella M, Young RM, June CH. Watanabe K, et al. Blood Adv. 2023 Jul 25;7(14):3416-3430. doi: 10.1182/bloodadvances.2022008327. Blood Adv. 2023. PMID: 37058474 Free PMC article.
Moreover, fratricide increased the percentage of CAR+ T cells in the final product. CCR4-CAR T cells were characterized by high transduction efficiency, robust T-cell expansion, and rapid fratricidal depletion of CCR4-positive T cells during CAR transduction and exp …
Moreover, fratricide increased the percentage of CAR+ T cells in the final product. CCR4-CAR T cells were characterized by high trans …
CCR4 in cutaneous T-cell lymphoma: Therapeutic targeting of a pathogenic driver.
Nicolay JP, Albrecht JD, Alberti-Violetti S, Berti E. Nicolay JP, et al. Eur J Immunol. 2021 Jul;51(7):1660-1671. doi: 10.1002/eji.202049043. Epub 2021 May 7. Eur J Immunol. 2021. PMID: 33811642 Free article. Review.
The interaction of CCR4 with its dominant ligands CCL17 and CCL22 plays a critical role in the development and progression of CTCL, facilitating the movement into, and accumulation of, CCR4-expressing T cells in the skin, and recruiting CCR4-expressing Tregs …
The interaction of CCR4 with its dominant ligands CCL17 and CCL22 plays a critical role in the development and progression of CTCL, f …
Ccr4-Not as a mediator of environmental signaling: a jack of all trades and master of all.
Laribee RN. Laribee RN. Curr Genet. 2021 Oct;67(5):707-713. doi: 10.1007/s00294-021-01180-5. Epub 2021 Mar 31. Curr Genet. 2021. PMID: 33791857 Free PMC article. Review.
Herein, I will review the current evidence that implicate Ccr4-Not in nutrient signaling regulation, and I will discuss important unanswered questions that should help guide future efforts to delineate Ccr4-Not's role in linking environmental signaling with the gene …
Herein, I will review the current evidence that implicate Ccr4-Not in nutrient signaling regulation, and I will discuss important una …
The Regulatory Properties of the Ccr4-Not Complex.
Chalabi Hagkarim N, Grand RJ. Chalabi Hagkarim N, et al. Cells. 2020 Oct 29;9(11):2379. doi: 10.3390/cells9112379. Cells. 2020. PMID: 33138308 Free PMC article. Review.
The mammalian Ccr4-Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. ...In this review, we summarize …
The mammalian Ccr4-Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserve …
CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy.
Bogacka J, Pawlik K, Ciapała K, Ciechanowska A, Mika J. Bogacka J, et al. Int J Mol Sci. 2022 Dec 9;23(24):15638. doi: 10.3390/ijms232415638. Int J Mol Sci. 2022. PMID: 36555280 Free PMC article. Review.
The pharmacological blockade of CCR4 seems beneficial because of its pain-relieving effects and its influence on opioid efficacy. The possibilities of using the CCL2/CCL17/CCL22/CCR4 axis as a target in new therapies for many diseases are also discussed....
The pharmacological blockade of CCR4 seems beneficial because of its pain-relieving effects and its influence on opioid efficacy. The …
CCR4 and its ligands: from bench to bedside.
Yoshie O, Matsushima K. Yoshie O, et al. Int Immunol. 2015 Jan;27(1):11-20. doi: 10.1093/intimm/dxu079. Epub 2014 Aug 2. Int Immunol. 2015. PMID: 25087232 Review.
Thus, CCR4 attracts much attention for its possible clinical applications in diseases involving these T-cell subsets. ...This article is a brief overview of basic and clinical research on CCR4 and its ligands, which has eventually led to the development of a humaniz …
Thus, CCR4 attracts much attention for its possible clinical applications in diseases involving these T-cell subsets. ...This article …
The Ccr4--not complex.
Collart MA, Panasenko OO. Collart MA, et al. Gene. 2012 Jan 15;492(1):42-53. doi: 10.1016/j.gene.2011.09.033. Epub 2011 Oct 15. Gene. 2012. PMID: 22027279 Review.
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. ...This model suggests that the Ccr4-Not complex might function as a "chaperone platform"....
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular fun …
The Ccr4-Not Complex: Architecture and Structural Insights.
Collart MA, Panasenko OO. Collart MA, et al. Subcell Biochem. 2017;83:349-379. doi: 10.1007/978-3-319-46503-6_13. Subcell Biochem. 2017. PMID: 28271483 Review.
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . It has a conserved core of three Not proteins, the Ccr4 pro …
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and ha …
2,938 results