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Year Number of Results
2001 1
2006 3
2007 1
2008 2
2009 1
2013 1
2014 1
2015 1
2016 2
2017 1
2018 1
2019 1
2020 7
2021 17
2022 6
2023 5
2024 5

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49 results

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Page 1
A Pan-Cancer Analysis of the Oncogenic Role of Cell Division Cycle-Associated Protein 4 (CDCA4) in Human Tumors.
Fang H, Sheng S, Chen B, Wang J, Mao D, Han Y, Liu Y, Wang X, Gui S, Zhang T, Zhang L, Li C, Hu X, Deng W, Liu X, Xu H, Xu W, Wang X, Liu R, Kong W. Fang H, et al. Front Immunol. 2022 Feb 17;13:826337. doi: 10.3389/fimmu.2022.826337. eCollection 2022. Front Immunol. 2022. PMID: 35251007 Free PMC article.
Elevated CDCA4 expression was associated with poor OS and DFS. There was a significant correlation between CDCA4 expression and TITCs. ...Conversely, methylation is negative correlation with CDCA4 expression. Molecular biology experiments confirm a cancer pro …
Elevated CDCA4 expression was associated with poor OS and DFS. There was a significant correlation between CDCA4 expression an …
CDCA4 interacts with IGF2BP1 to regulate lung adenocarcinoma proliferation via the PI3K/AKT pathway.
Feng S, Cao H, Sui Y, Shen Z, Wu J, Ma R, Feng J. Feng S, et al. Thorac Cancer. 2023 Mar;14(8):724-735. doi: 10.1111/1759-7714.14800. Epub 2023 Feb 3. Thorac Cancer. 2023. PMID: 36737405 Free PMC article.
A xenograft model was used to examine how CDCA4 knockdown affects LUAD cells growth in vivo. RESULTS: We found that the expression of CDCA4 was upregulated in LUAD cell lines. ...Moreover, we demonstrated that CDCA4 favorably regulated IGF2BP1, a downstream t …
A xenograft model was used to examine how CDCA4 knockdown affects LUAD cells growth in vivo. RESULTS: We found that the expression of …
CDCA4 as a novel molecular biomarker of poor prognosis in patients with lung adenocarcinoma.
Tan J, Chen F, Ouyang B, Li X, Zhang W, Gao X. Tan J, et al. Front Oncol. 2022 Sep 15;12:865756. doi: 10.3389/fonc.2022.865756. eCollection 2022. Front Oncol. 2022. PMID: 36185189 Free PMC article.
METHODS: CDCA4 expression was assessed through IHC, Western blotting (WB) and RT-PCR. ...Then multivariate COX regression analyses indicated that the CDCA4 gene was an independent risk consideration for prognoses. GO and KEGG results showed that CDCA4 and its …
METHODS: CDCA4 expression was assessed through IHC, Western blotting (WB) and RT-PCR. ...Then multivariate COX regression analyses in …
CDCA4 suppresses epithelial-mesenchymal transtion (EMT) and metastasis in Non-small cell lung cancer through modulating autophagy.
Xu C, Cao H, Sui Y, Zhang H, Shi C, Wu J, Ma R, Feng J. Xu C, et al. Cancer Cell Int. 2021 Jan 12;21(1):48. doi: 10.1186/s12935-021-01754-w. Cancer Cell Int. 2021. PMID: 33436008 Free PMC article.
The function of CDCA4 in Non-small cell lung cancer (NSCLC) was unknown. We aimed to explore the critical role of CDCA4 in NSCLC. ...Correspondingly, the application of rapamycin or 3-MA to CDCA4 knockdown cells showed the opposite effects. Further investigat …
The function of CDCA4 in Non-small cell lung cancer (NSCLC) was unknown. We aimed to explore the critical role of CDCA4 in NSC …
Ubiquitin-independent proteasomal degradation driven by C-degron pathways.
Makaros Y, Raiff A, Timms RT, Wagh AR, Gueta MI, Bekturova A, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I. Makaros Y, et al. Mol Cell. 2023 Jun 1;83(11):1921-1935.e7. doi: 10.1016/j.molcel.2023.04.023. Epub 2023 May 17. Mol Cell. 2023. PMID: 37201526 Free PMC article.
Stability profiling of a genome-wide collection of human open reading frames identified 69 full-length proteins subject to UbInPD. These included REC8 and CDCA4, proteins which control proliferation and survival, as well as mislocalized secretory proteins, suggesting that …
Stability profiling of a genome-wide collection of human open reading frames identified 69 full-length proteins subject to UbInPD. These inc …
CDCA4, a downstream gene of the Nrf2 signaling pathway, regulates cell proliferation and apoptosis in the MCF-7/ADM human breast cancer cell line.
Xu Y, Wu X, Li F, Huang D, Zhu W. Xu Y, et al. Mol Med Rep. 2018 Jan;17(1):1507-1512. doi: 10.3892/mmr.2017.8095. Epub 2017 Nov 15. Mol Med Rep. 2018. PMID: 29257222 Free PMC article.
CDCA4 has been shown to have a unique role in regulating cell cycle. In the present study, the expression of CDCA4 was suppressed by CDCA4-specific short hairpin (sh)RNA transfection of the human breast cancer cells, following which changes in the proliferati …
CDCA4 has been shown to have a unique role in regulating cell cycle. In the present study, the expression of CDCA4 was suppres …
Upregulation of miR-29c-3p Hinders Melanoma Progression by Inhibiting CDCA4 Expression.
Liu J, Tao G, Zhong C, Liu X. Liu J, et al. Biomed Res Int. 2021 Aug 28;2021:7065963. doi: 10.1155/2021/7065963. eCollection 2021. Biomed Res Int. 2021. PMID: 34497853 Free PMC article. Retracted.
MM cell lines (M21 and C8161) were transfected with miR-29c-3p-mimics, miR-29c-3p-inhibitor, miR-NC, si-CDCA4, and sh-CDCA4. The expression of miR-29c-3p, CDCA4, Bax, Caspase3, Bcl-2, N-cadherin, vimentin, and E-cadherin was quantified, and cell proliferation …
MM cell lines (M21 and C8161) were transfected with miR-29c-3p-mimics, miR-29c-3p-inhibitor, miR-NC, si-CDCA4, and sh-CDCA4. T …
CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation.
Hayashi R, Goto Y, Ikeda R, Yokoyama KK, Yoshida K. Hayashi R, et al. J Biol Chem. 2006 Nov 24;281(47):35633-48. doi: 10.1074/jbc.M603800200. Epub 2006 Sep 19. J Biol Chem. 2006. PMID: 16984923 Free article.
Analysis of CDCA4 promoter constructs showed that an E2F-responsive sequence in the vicinity of the transcription initiation site is necessary for the E2F1-4-induced activation of CDCA4 gene transcription. ...Conversely, CDCA4 suppressed E2F1-3-induced report …
Analysis of CDCA4 promoter constructs showed that an E2F-responsive sequence in the vicinity of the transcription initiation site is …
Circ_0010220-mediated miR-503-5p/CDCA4 axis contributes to osteosarcoma progression tumorigenesis.
Li J, Zhang F, Li H, Peng F, Wang Z, Peng H, He J, Li Y, He L, Wei L. Li J, et al. Gene. 2020 Dec 30;763:145068. doi: 10.1016/j.gene.2020.145068. Epub 2020 Aug 19. Gene. 2020. PMID: 32827680
Then, our study demonstrated that Cell Division Cycle-Associated protein 4 (CDCA4) could be a downstream target of miR-503-5p. Additionally, circ_0010220 down-regulation reduced CDCA4 expression level and the inhibitors of miR-503-5p reversed that. In conclusion, we …
Then, our study demonstrated that Cell Division Cycle-Associated protein 4 (CDCA4) could be a downstream target of miR-503-5p. Additi …
MiR-497-5p down-regulates CDCA4 to restrains lung squamous cell carcinoma progression.
Hu J, Xiang X, Guan W, Lou W, He J, Chen J, Fu Y, Lou G. Hu J, et al. J Cardiothorac Surg. 2021 Nov 12;16(1):330. doi: 10.1186/s13019-021-01698-2. J Cardiothorac Surg. 2021. PMID: 34772428 Free PMC article.
Overexpressed miR-497-5p markedly inhibited cancer progression. miR-497-5p restrained CDCA4 expression. Rescue assay showed that overexpressing miR-497-5p eliminated effect of overexpressed CDCA4. CONCLUSION: By targeting CDCA4, miR-497-5p restrained developm …
Overexpressed miR-497-5p markedly inhibited cancer progression. miR-497-5p restrained CDCA4 expression. Rescue assay showed that over …
49 results