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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2004 4
2005 3
2006 8
2007 9
2008 9
2009 6
2010 5
2011 3
2012 10
2013 4
2014 4
2015 9
2016 4
2017 7
2018 7
2019 17
2020 33
2021 22
2022 37
2023 23
2024 13

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222 results

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Page 1
CDCA8 promotes bladder cancer survival by stabilizing HIF1alpha expression under hypoxia.
Zhou Q, Huang W, Xiong J, Guo B, Wang X, Guo J. Zhou Q, et al. Cell Death Dis. 2023 Oct 9;14(10):658. doi: 10.1038/s41419-023-06189-x. Cell Death Dis. 2023. PMID: 37813876 Free PMC article.
The expression of CDCA8 proteins was required for BCa cells to survive in the hypoxic condition. ...Together, we defined CDCA8 as a key regulator for BCa cells to sense and prevail oxygen deprivation and as a novel BCa therapeutic target....
The expression of CDCA8 proteins was required for BCa cells to survive in the hypoxic condition. ...Together, we defined CDCA8 …
CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway.
Chen E, He Y, Jiang J, Yi J, Zou Z, Song Q, Ren Q, Lin Z, Lu Y, Liu J, Zhang J. Chen E, et al. Exp Hematol Oncol. 2023 Jan 13;12(1):9. doi: 10.1186/s40164-022-00366-y. Exp Hematol Oncol. 2023. PMID: 36639822 Free PMC article.
RESULTS: CDCA8 was identified as a novel oncogene during HCC development. ...Furthermore, NA-YA overexpression upregulated the expression of CDCA8. CDCA8 knockdown could attenuate NF-YA-mediated cell invasion in vitro. ...
RESULTS: CDCA8 was identified as a novel oncogene during HCC development. ...Furthermore, NA-YA overexpression upregulated the expres …
CDCA8 Contributes to the Development and Progression of Thyroid Cancer through Regulating CDK1.
Xiang C, Sun WH, Ke Y, Yu X, Wang Y. Xiang C, et al. J Cancer. 2022 Apr 18;13(7):2322-2335. doi: 10.7150/jca.64747. eCollection 2022. J Cancer. 2022. PMID: 35517403 Free PMC article.
Moreover, overexpression of CDK1 could weaken the tumor suppressive effect caused by CDCA8 knockdown. Conclusions: CDCA8 functions as an oncogene in thyroid cancer, and CDCA8 knockdown suppresses cancer development in vitro and in vivo. Additionally, CDK1 was …
Moreover, overexpression of CDK1 could weaken the tumor suppressive effect caused by CDCA8 knockdown. Conclusions: CDCA8 funct …
CDCA8 as an independent predictor for a poor prognosis in liver cancer.
Shuai Y, Fan E, Zhong Q, Chen Q, Feng G, Gou X, Zhang G. Shuai Y, et al. Cancer Cell Int. 2021 Mar 8;21(1):159. doi: 10.1186/s12935-021-01850-x. Cancer Cell Int. 2021. PMID: 33685433 Free PMC article.
Gene set enrichment analysis (GSEA) was performed to explore possible mechanisms of CDCA8 according to the TCGA dataset. RESULTS: CDCA8 expression was higher in liver cancer tissues than in matched normal tissues. ...GSEA revealed that the apoptosis, cell cycle, Erb …
Gene set enrichment analysis (GSEA) was performed to explore possible mechanisms of CDCA8 according to the TCGA dataset. RESULTS: …
CDCA8/SNAI2 Complex Activates CD44 to Promote Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma.
Gu J, Guo Y, Du J, Kong L, Deng J, Tao B, Li H, Jin C, Fu D, Li J. Gu J, et al. Cancers (Basel). 2022 Nov 4;14(21):5434. doi: 10.3390/cancers14215434. Cancers (Basel). 2022. PMID: 36358852 Free PMC article.
CDCA8 knockdown inhibited PDAC proliferation and invasion in in vitro and in vivo assays. CD44 was also up-regulated by CDCA8 during PDAC progression. CDCA8 could be combined with SNAI2 to form a CDCA8/SNAI2 complex to integrate with the CD44 promoter …
CDCA8 knockdown inhibited PDAC proliferation and invasion in in vitro and in vivo assays. CD44 was also up-regulated by CDCA8 …
CDCA8, targeted by MYBL2, promotes malignant progression and olaparib insensitivity in ovarian cancer.
Qi G, Zhang C, Ma H, Li Y, Peng J, Chen J, Kong B. Qi G, et al. Am J Cancer Res. 2021 Feb 1;11(2):389-415. eCollection 2021. Am J Cancer Res. 2021. PMID: 33575078 Free PMC article.
Here, we found that CDCA8 was overexpressed in ovarian cancer and that high expression of CDCA8 promoted the proliferation of ovarian cancer cells in vitro and in vivo. ...In addition, MYBL2 (MYB proto-oncogene-like 2), identified as an upstream transcription factor …
Here, we found that CDCA8 was overexpressed in ovarian cancer and that high expression of CDCA8 promoted the proliferation of …
CDCA8 regulates meiotic spindle assembly and chromosome segregation during human oocyte meiosis.
Zhang C, Zhao L, Leng L, Zhou Q, Zhang S, Gong F, Xie P, Lin G. Zhang C, et al. Gene. 2020 May 30;741:144495. doi: 10.1016/j.gene.2020.144495. Epub 2020 Feb 20. Gene. 2020. PMID: 32088244
Here, we show that CDCA8 expression is increased and its encoded protein has dynamic localization in human oocytes from germinal vesicle breakdown (GVBD) to metaphase (M), and that there are multipolar spindles, disordered chromosomes, and that microtubule assembly is affe …
Here, we show that CDCA8 expression is increased and its encoded protein has dynamic localization in human oocytes from germinal vesi …
Overexpression of CDCA8 Predicts Poor Prognosis and Promotes Tumor Cell Growth in Prostate Cancer.
Wan S, He Y, Zhang B, Yang Z, Du FM, Zhang CP, Fu YQ, Mi J. Wan S, et al. Front Oncol. 2022 Apr 5;12:784183. doi: 10.3389/fonc.2022.784183. eCollection 2022. Front Oncol. 2022. PMID: 35449575 Free PMC article.
To further understand the role of CDCA8 in PCa, we assessed the effects of CDCA8 on PCa cell growth, proliferation, and migration in vitro studies. ...High CDCA8 expression predicts poor prognosis in PCa patients, and CDCA8 expression was higher in hig …
To further understand the role of CDCA8 in PCa, we assessed the effects of CDCA8 on PCa cell growth, proliferation, and migrat …
CDCA8 expression and its clinical relevance in patients with bladder cancer.
Bi Y, Chen S, Jiang J, Yao J, Wang G, Zhou Q, Li S. Bi Y, et al. Medicine (Baltimore). 2018 Aug;97(34):e11899. doi: 10.1097/MD.0000000000011899. Medicine (Baltimore). 2018. PMID: 30142792 Free PMC article.
The purpose of this study was to identify the expression of CDCA8 and its clinical relevance in BC patients.GEO datasets were employed to obtain CDCA8 expression data and its clinical information in BC samples. ...Biological processes or signaling pathways that migh …
The purpose of this study was to identify the expression of CDCA8 and its clinical relevance in BC patients.GEO datasets were employe …
Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/beta-Catenin Signaling.
Jeon T, Ko MJ, Seo YR, Jung SJ, Seo D, Park SY, Park KU, Kim KS, Kim M, Seo JH, Park IC, Kim MJ, Bae JH, Song DK, Cho CH, Lee JH, Lee YH. Jeon T, et al. Cancers (Basel). 2021 Mar 2;13(5):1055. doi: 10.3390/cancers13051055. Cancers (Basel). 2021. PMID: 33801424 Free PMC article.
However, the functions of CDCA8 during HCC development remain unknown. Here, we demonstrate in vitro that CDCA8 silencing inhibits HCC cell growth and long-term colony formation and migration through the accumulation of the G2/M phase cell population. Conversely, …
However, the functions of CDCA8 during HCC development remain unknown. Here, we demonstrate in vitro that CDCA8 silencing inhi …
222 results