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2001 1
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2012 14
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275 results

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Page 1
Cdh11: Roles in different diseases and potential value in disease diagnosis and treatment.
Zhang G, Wang X, Zhang Q. Zhang G, et al. Biochem Biophys Rep. 2023 Nov 15;36:101576. doi: 10.1016/j.bbrep.2023.101576. eCollection 2023 Dec. Biochem Biophys Rep. 2023. PMID: 38034129 Free PMC article. Review.
In various tumorous diseases, CDH11 acts not only as a tumor suppressor but can also promote migration and invasion of certain tumors through various mechanisms. Likewise, in non-tumorous diseases, CDH11 remains a pivotal factor in disease progression. In this conte …
In various tumorous diseases, CDH11 acts not only as a tumor suppressor but can also promote migration and invasion of certain tumors …
CDH11 promotes liver fibrosis via activation of hepatic stellate cells.
Ruan W, Pan R, Shen X, Nie Y, Wu Y. Ruan W, et al. Biochem Biophys Res Commun. 2019 Jan 8;508(2):543-549. doi: 10.1016/j.bbrc.2018.11.153. Epub 2018 Nov 30. Biochem Biophys Res Commun. 2019. PMID: 30509494
Here we demonstrate that CDH11 expression is elevated in human and mouse fibrotic liver tissues and that CDH11 mediates the profibrotic response in activated HSCs. Our data indicate that CDH11 regulates the TGFbeta-induced activation of HSCs. Moreover, cells …
Here we demonstrate that CDH11 expression is elevated in human and mouse fibrotic liver tissues and that CDH11 mediates the pr …
CDH11 Regulates Adhesion and Transcellular Migration of Tongue Squamous Cell Carcinoma.
Zheng BT, Li QL, Lan T, Xie J, Lu YG, Zheng DL, Su BH. Zheng BT, et al. Onco Targets Ther. 2021 Jul 16;14:4211-4222. doi: 10.2147/OTT.S298614. eCollection 2021. Onco Targets Ther. 2021. PMID: 34295163 Free PMC article.
PURPOSE: CDH11, as a member of cadherins, mediates homotypic cell adhesion. ...While features of CDH11 in tongue squamous cell carcinoma (TSCC) are still indeterminate, the purpose of the present study is to explore the role of CDH11 in TSCC. ...
PURPOSE: CDH11, as a member of cadherins, mediates homotypic cell adhesion. ...While features of CDH11 in tongue squamous cell …
CDH11 inhibits proliferation and invasion in head and neck cancer.
Piao S, Inglehart RC, Scanlon CS, Russo N, Banerjee R, D'Silva NJ. Piao S, et al. J Oral Pathol Med. 2017 Feb;46(2):89-97. doi: 10.1111/jop.12471. Epub 2016 Jul 10. J Oral Pathol Med. 2017. PMID: 27397103 Free article.
RESULTS: In silico analysis suggested that CDH11 is overexpressed in HNSCC compared to normal specimens. HNSCC TMA exhibited a small but significant increase in intensity and proportion of CDH11. ...CONCLUSION: CDH11 inhibits cell proliferation and invasion o …
RESULTS: In silico analysis suggested that CDH11 is overexpressed in HNSCC compared to normal specimens. HNSCC TMA exhibited a small …
CDH2 and CDH11 act as regulators of stem cell fate decisions.
Alimperti S, Andreadis ST. Alimperti S, et al. Stem Cell Res. 2015 May;14(3):270-82. doi: 10.1016/j.scr.2015.02.002. Epub 2015 Feb 19. Stem Cell Res. 2015. PMID: 25771201 Free PMC article. Review.
In this review, we focus on the role of cadherin mediated signaling in development and stem cell differentiation, with emphasis on two well-known cadherins, cadherin-2 (CDH2) (N-cadherin) and cadherin-11 (CDH11) (OB-cadherin). We summarize the existing knowledge regarding …
In this review, we focus on the role of cadherin mediated signaling in development and stem cell differentiation, with emphasis on two well- …
Extracellular Vesicle-Packaged CDH11 and ITGA5 Induce the Premetastatic Niche for Bone Colonization of Breast Cancer Cells.
Li XQ, Zhang R, Lu H, Yue XM, Huang YF. Li XQ, et al. Cancer Res. 2022 Apr 15;82(8):1560-1574. doi: 10.1158/0008-5472.CAN-21-1331. Cancer Res. 2022. PMID: 35149589
Furthermore, different extracellular vesicular proteins were identified that mediate events subsequent to the specific recognition of tumor-derived EVs by osteoblasts via cadherin 11 (CDH11) and the induction of the osteogenic premetastatic niche by integrin alpha5 (ITGA5) …
Furthermore, different extracellular vesicular proteins were identified that mediate events subsequent to the specific recognition of tumor- …
Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
Peran I, Dakshanamurthy S, McCoy MD, Mavropoulos A, Allo B, Sebastian A, Hum NR, Sprague SC, Martin KA, Pishvaian MJ, Vietsch EE, Wellstein A, Atkins MB, Weiner LM, Quong AA, Loots GG, Yoo SS, Assefnia S, Byers SW. Peran I, et al. Gastroenterology. 2021 Mar;160(4):1359-1372.e13. doi: 10.1053/j.gastro.2020.11.044. Epub 2020 Dec 9. Gastroenterology. 2021. PMID: 33307028 Free PMC article.
KPC/Cdh11(+/-) and KPC/Cdh11(-/-) mice survived significantly longer than KPC/Cdh11(+/+) mice. ...Administration of the PD1 antibody did not prolong survival of KPC mice with 0, 1, or 2 alleles of Cdh11. Gemcitabine extended survival of KPC/Cdh11 …
KPC/Cdh11(+/-) and KPC/Cdh11(-/-) mice survived significantly longer than KPC/Cdh11(+/+) mice. ...Administration of the …
Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome.
Li D, March ME, Fortugno P, Cox LL, Matsuoka LS, Monetta R, Seiler C, Pyle LC, Bedoukian EC, Sánchez-Soler MJ, Caluseriu O, Grand K, Tam A, Aycinena ARP, Camerota L, Guo Y, Sleiman P, Callewaert B, Kumps C, Dheedene A, Buckley M, Kirk EP, Turner A, Kamien B, Patel C, Wilson M, Roscioli T, Christodoulou J, Cox TC, Zackai EH, Brancati F, Hakonarson H, Bhoj EJ. Li D, et al. Hum Genet. 2021 Jul;140(7):1061-1076. doi: 10.1007/s00439-021-02274-3. Epub 2021 Apr 3. Hum Genet. 2021. PMID: 33811546 Free PMC article.
We report THS due to CDH11 heterozygous missense variants on 19 subjects from 9 families. ...These features distinguished this phenotype from that seen in SPECC1L-related hypertelorism syndrome and CDH11-related EWS. Our results demonstrate heterozygous variants in …
We report THS due to CDH11 heterozygous missense variants on 19 subjects from 9 families. ...These features distinguished this phenot …
Downregulation of CDH11 Promotes Metastasis and Resistance to Paclitaxel in Gastric Cancer Cells.
Yang Z, Yan C, Yu Z, He C, Li J, Li C, Yan M, Liu B, Wu Y, Zhu Z. Yang Z, et al. J Cancer. 2021 Jan 1;12(1):65-75. doi: 10.7150/jca.48193. eCollection 2021. J Cancer. 2021. PMID: 33391403 Free PMC article.
Results: CDH11 expression was downregulated in the relapsed PTX-resistant ascites, tissues and the PTX-resistant cell line MKN45P-PR. Inhibition of CDH11 expression promoted the invasion, migration and PTX resistance of MKN45P cells, while overexpression of CDH11 …
Results: CDH11 expression was downregulated in the relapsed PTX-resistant ascites, tissues and the PTX-resistant cell line MKN45P-PR. …
Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.
Marchong MN, Yurkowski C, Ma C, Spencer C, Pajovic S, Gallie BL. Marchong MN, et al. PLoS Genet. 2010 Apr 22;6(4):e1000923. doi: 10.1371/journal.pgen.1000923. PLoS Genet. 2010. PMID: 20421947 Free PMC article.
To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with TAg-RB mice. Loss of Cdh11 had no gross morphological effect on the developing retina of Cdh11 knockout mice, but led to larger retinal volumes in mice crossed with …
To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with TAg-RB mice. Loss of Cdh11 had …
275 results