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Year Number of Results
2010 2
2011 1
2012 4
2013 3
2014 6
2015 10
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2017 15
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2019 20
2020 22
2021 18
2022 13
2023 13
2024 13
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147 results

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Page 1
CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.
Zarate YA, Uehara T, Abe K, Oginuma M, Harako S, Ishitani S, Lehesjoki AE, Bierhals T, Kloth K, Ehmke N, Horn D, Holtgrewe M, Anderson K, Viskochil D, Edgar-Zarate CL, Sacoto MJG, Schnur RE, Morrow MM, Sanchez-Valle A, Pappas J, Rabin R, Muona M, Anttonen AK, Platzer K, Luppe J, Gburek-Augustat J, Kaname T, Okamoto N, Mizuno S, Kaido Y, Ohkuma Y, Hirose Y, Ishitani T, Kosaki K. Zarate YA, et al. Genet Med. 2021 Jun;23(6):1050-1057. doi: 10.1038/s41436-020-01091-9. Epub 2021 Jan 25. Genet Med. 2021. PMID: 33495529 Free article.
Functional studies included autophosphorylation assays for CDK19 Gly28Arg and Tyr32His variants and in vivo zebrafish assays of the CDK19(G28R) and CDK19(Y32H). ...CONCLUSION: CDK19 de novo missense variants are responsible for a novel neurodevelopment …
Functional studies included autophosphorylation assays for CDK19 Gly28Arg and Tyr32His variants and in vivo zebrafish assays of the …
CDK19 as a diagnostic marker for high-grade prostatic intraepithelial neoplasia.
Offermann A, Joerg V, Hupe MC, Becker F, Müller M, Brägelmann J, Kirfel J, Merseburger AS, Sailer V, Tharun L, Perner S. Offermann A, et al. Hum Pathol. 2021 Nov;117:60-67. doi: 10.1016/j.humpath.2021.07.006. Epub 2021 Jul 24. Hum Pathol. 2021. PMID: 34314763
HGPIN was present in 65.7% of biopsies and in 88% associated to adjacent PCa. CDK19 overexpression defined as moderate to high CDK19 expression visible at low magnification was found in 82.6% of HGPIN. In contrast, 89.3% of benign glands were CDK19-negative o …
HGPIN was present in 65.7% of biopsies and in 88% associated to adjacent PCa. CDK19 overexpression defined as moderate to high CDK …
Regulatory functions of the Mediator kinases CDK8 and CDK19.
Fant CB, Taatjes DJ. Fant CB, et al. Transcription. 2019 Apr;10(2):76-90. doi: 10.1080/21541264.2018.1556915. Epub 2018 Dec 26. Transcription. 2019. PMID: 30585107 Free PMC article. Review.
The Mediator-associated kinases CDK8 and CDK19 function in the context of three additional proteins: CCNC and MED12, which activate CDK8/CDK19 kinase function, and MED13, which enables their association with the Mediator complex. ...We focus on sequence-specific, DN …
The Mediator-associated kinases CDK8 and CDK19 function in the context of three additional proteins: CCNC and MED12, which activate C …
CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC.
Paulsen FO, Idel C, Ribbat-Idel J, Kuppler P, Klapper L, Rades D, Bruchhage KL, Wollenberg B, Brägelmann J, Perner S, Offermann A. Paulsen FO, et al. Int J Mol Sci. 2020 Jul 31;21(15):5508. doi: 10.3390/ijms21155508. Int J Mol Sci. 2020. PMID: 32752128 Free PMC article.
Patients with high-CDK19-expressing primary tumors have a significantly shorter disease-free survival. ...Our findings identify CDK19 as a potential biomarker in HNSCC to predict recurrent disease and support recent developments to target CDK19 and its paralo …
Patients with high-CDK19-expressing primary tumors have a significantly shorter disease-free survival. ...Our findings identify CD …
PET imaging of new target CDK19 in prostate cancer.
Dai D, Yu J, Huang T, Li Y, Wang Z, Yang S, Li S, Li Y, Gou W, Li D, Hou W, Fan S, Li Y, Zhao Y. Dai D, et al. Eur J Nucl Med Mol Imaging. 2023 Sep;50(11):3452-3464. doi: 10.1007/s00259-023-06277-2. Epub 2023 Jun 6. Eur J Nucl Med Mol Imaging. 2023. PMID: 37278941
RESULTS: Our study group had reported the overexpression of a novel tissue-specific gene CDK19 in high-risk metastatic prostate cancer and CDK19 expression correlated with metastatic status and tumor staging, independently with PSMA and PSA levels. ...Furthermore, t …
RESULTS: Our study group had reported the overexpression of a novel tissue-specific gene CDK19 in high-risk metastatic prostate cance …
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB. Chen M, et al. Nucleic Acids Res. 2023 Aug 11;51(14):7288-7313. doi: 10.1093/nar/gkad538. Nucleic Acids Res. 2023. PMID: 37378433 Free PMC article.
This analysis was performed using genetic modifications of CDK8 and CDK19, selective CDK8/19 small molecule kinase inhibitors and a potent CDK8/19 PROTAC degrader. ...Regulation of both RNA and protein expression required CDK8/19 kinase activities but both enzymes protecte …
This analysis was performed using genetic modifications of CDK8 and CDK19, selective CDK8/19 small molecule kinase inhibitors and a p …
CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.
Zhang Z, Lu Y, Qi Y, Xu Y, Wang S, Chen F, Shen M, Chen M, Chen N, Yang L, Chen S, Wang F, Su Y, Hu M, Wang J. Zhang Z, et al. Leukemia. 2022 Apr;36(4):956-969. doi: 10.1038/s41375-022-01512-5. Epub 2022 Feb 2. Leukemia. 2022. PMID: 35110726
Furthermore, SenexinB (a CDK8/19 inhibitor) treatment impairs the proliferation and self-renewal ability of HSCs. Moreover, overexpression of CDK19 promotes HSC function better than CDK8 overexpression. Using CDK19 knockout mice, we observe that CDK19(-/-) HS …
Furthermore, SenexinB (a CDK8/19 inhibitor) treatment impairs the proliferation and self-renewal ability of HSCs. Moreover, overexpression o …
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules.
Dannappel MV, Sooraj D, Loh JJ, Firestein R. Dannappel MV, et al. Front Cell Dev Biol. 2019 Jan 14;6:171. doi: 10.3389/fcell.2018.00171. eCollection 2018. Front Cell Dev Biol. 2019. PMID: 30693281 Free PMC article. Review.
CDK8 and its paralog, CDK19, collectively termed 'Mediator Kinase,' are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner, as par …
CDK8 and its paralog, CDK19, collectively termed 'Mediator Kinase,' are cyclin-dependent kinases that have been implicated as key rhe …
Increased mediator complex subunit CDK19 expression associates with aggressive prostate cancer.
Becker F, Joerg V, Hupe MC, Roth D, Krupar R, Lubczyk V, Kuefer R, Sailer V, Duensing S, Kirfel J, Merseburger AS, Brägelmann J, Perner S, Offermann A. Becker F, et al. Int J Cancer. 2020 Jan 15;146(2):577-588. doi: 10.1002/ijc.32551. Epub 2019 Jul 19. Int J Cancer. 2020. PMID: 31271443 Free article.
High CDK19 expression on primary tumors correlates with DFS independently from Gleason grade and PSA. ...In the current study, we confirmed an important role of the Mediator subunit CDK19 in advanced PCa supporting current developments to target CDK19 and its …
High CDK19 expression on primary tumors correlates with DFS independently from Gleason grade and PSA. ...In the current study, we con …
Hsa_circ_0006692 Promotes Lung Cancer Progression via miR-205-5p/CDK19 Axis.
Liao J, Chen Z, Luo X, Su Y, Huang T, Xu H, Lin K, Zheng Q, Zhang L, Lin G, Lin X. Liao J, et al. Genes (Basel). 2022 May 10;13(5):846. doi: 10.3390/genes13050846. Genes (Basel). 2022. PMID: 35627232 Free PMC article.
Nevertheless, the regulation and function of hsa_circ_0006692 and its interactions with miR-205-5p and CDK19 in the development of non-small-cell lung cancer (NSCLC) were un-explored. ...This study revealed that hsa_circ_0006692 promoted NSCLC progression via enhancing cel …
Nevertheless, the regulation and function of hsa_circ_0006692 and its interactions with miR-205-5p and CDK19 in the development of no …
147 results