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Page 1
Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker.
Pérez-Morales J, Mejías-Morales D, Rivera-Rivera S, González-Flores J, González-Loperena M, Cordero-Báez FY, Pedreira-García WM, Chardón-Colón C, Cabán-Rivera J, Cress WD, Gordian ER, Muñoz-Antonia T, Cabrera-Ríos M, Isidro A, Coppola D, Rosa M, Boyle TA, Izumi V, Koomen JM, Santiago-Cardona PG. Pérez-Morales J, et al. PLoS One. 2018 Nov 19;13(11):e0207483. doi: 10.1371/journal.pone.0207483. eCollection 2018. PLoS One. 2018. PMID: 30452490 Free PMC article.
Integrated analysis of transcription factor-mRNA-miRNA regulatory network related to immune characteristics in medullary thyroid carcinoma.
Weng D, He L, Chen X, Lin H, Ji D, Lu S, Ao L, Wang S. Weng D, et al. Front Immunol. 2023 Jan 12;13:1055412. doi: 10.3389/fimmu.2022.1055412. eCollection 2022. Front Immunol. 2023. PMID: 36713370 Free PMC article.
Based on the identified 15 hub genes, a TF-mRNA-miRNA linear network, as well as REST-cored coherent feed-forward loop networks, namely REST-KIF5C-miR-223 and REST-CDK5R2-miR-130a were constructed via online prediction and validation by public datasets and our cohort. ...
Based on the identified 15 hub genes, a TF-mRNA-miRNA linear network, as well as REST-cored coherent feed-forward loop networks, namely REST …
Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5.
Arif A. Arif A. Biochem Pharmacol. 2012 Oct 15;84(8):985-93. doi: 10.1016/j.bcp.2012.06.027. Epub 2012 Jul 4. Biochem Pharmacol. 2012. PMID: 22795893 Review.
Also atypical is the activation of Cdk5 by binding of a non-cyclin activator protein, namely, the Cdk5 regulatory proteins Cdk5R1 (p35), truncated Cdk5R1 (p25), or Cdk5R2 (p39). Despite its ubiquitous presence in all cells and tissues, Cdk5 is often referred to as a neuron …
Also atypical is the activation of Cdk5 by binding of a non-cyclin activator protein, namely, the Cdk5 regulatory proteins Cdk5R1 (p35), tru …
Comprehensive analyses identify potential biomarkers for encephalitis in HIV infection.
Wang S, Ding X, Li Z, Rao F, Xu H, Lu J, Ma X, Zhang M, Xie Z. Wang S, et al. Sci Rep. 2023 Oct 27;13(1):18418. doi: 10.1038/s41598-023-45922-6. Sci Rep. 2023. PMID: 37891420 Free PMC article.
Moreover, protein-protein interaction analysis revealed that 10 key HIVE-related genes were hub genes, including SCN8A, CDK5R2, GRM5, SCN2B, IFI44L, STAT1, SLC17A7, ISG15, FGF12, and FGF13. ...Finally, three hub genes (STAT1, ISG15, and SCN2B) interacted with several infla …
Moreover, protein-protein interaction analysis revealed that 10 key HIVE-related genes were hub genes, including SCN8A, CDK5R2, GRM5, …
Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice.
Takahashi M, Takasugi T, Kawakami A, Wei R, Ando K, Ohshima T, Hisanaga SI. Takahashi M, et al. Neurochem Res. 2022 Sep;47(9):2773-2779. doi: 10.1007/s11064-022-03642-9. Epub 2022 Jun 8. Neurochem Res. 2022. PMID: 35674931
When p39 KO mice were treated chronically with VPA, unexpectedly, they exhibited fewer anxiety and depression behaviors than WT mice. The effects were p39 cdk5r2 gene-dosage dependent. Together, these results indicate that Cdk5-p39 plays a specific role in VPA-induced anxi …
When p39 KO mice were treated chronically with VPA, unexpectedly, they exhibited fewer anxiety and depression behaviors than WT mice. The ef …
Construction and Comprehensive Analysis of ceRNA Networks and Tumor-Infiltrating Immune Cells in Hepatocellular Carcinoma With Vascular Invasion.
Cai S, Du R, Zhang Y, Yuan Z, Shang J, Yang Y, Han B, Zhong W, Yuan H, Li Z. Cai S, et al. Front Bioinform. 2022 Apr 12;2:836981. doi: 10.3389/fbinf.2022.836981. eCollection 2022. Front Bioinform. 2022. PMID: 36304284 Free PMC article.
The signature showed significant efficacy; its 3- and 5-year areas under the receiver operating characteristic curves were 0.712 and 0.653, respectively. ceRNA and ssGSEA integration analysis demonstrated that PART1 (p = 0, R = -0.33) and CDK5R2 (p = 0.01, R = -0.15) were …
The signature showed significant efficacy; its 3- and 5-year areas under the receiver operating characteristic curves were 0.712 and 0.653, …
Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival.
Martin D, Allagnat F, Gesina E, Caille D, Gjinovci A, Waeber G, Meda P, Haefliger JA. Martin D, et al. PLoS One. 2012;7(9):e45844. doi: 10.1371/journal.pone.0045844. Epub 2012 Sep 20. PLoS One. 2012. PMID: 23029270 Free PMC article.
Using siRNA-mediated knock-down in INS-1E cells, we showed that Cdk5r2 protects beta cells against cytokines and palmitate-induced apoptosis. Together, these data document that a set of REST target genes, including Cdk5r2, is important for beta cell survival....
Using siRNA-mediated knock-down in INS-1E cells, we showed that Cdk5r2 protects beta cells against cytokines and palmitate-induced ap …
Hyperthyroidism leads learning and memory impairment possibly via GRIN2B expression alterations.
Sahin L, Keloglan Müsüroglu S, Selin Cevik O, Cevik K, Orekici Temel G. Sahin L, et al. Brain Res. 2023 Mar 1;1802:148209. doi: 10.1016/j.brainres.2022.148209. Epub 2022 Dec 20. Brain Res. 2023. PMID: 36563833
Following blood collection, the rats were decapitated to isolate hippocampal tissue. GRIN2A, GRIN2B, BDNF, cFOS, Cdk5, cdk5r1 (p35), and cdk5r2 (p39) gene expression were evaluated using quantitative reverse transcriptase-PCR. ...
Following blood collection, the rats were decapitated to isolate hippocampal tissue. GRIN2A, GRIN2B, BDNF, cFOS, Cdk5, cdk5r1 (p35), and …
27 results