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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 5
1997 3
1998 7
1999 6
2000 6
2001 3
2002 9
2003 5
2004 14
2005 6
2006 11
2007 12
2008 14
2009 10
2010 18
2011 20
2012 14
2013 35
2014 42
2015 35
2016 33
2017 42
2018 42
2019 57
2020 64
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2022 48
2023 43
2024 37

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639 results

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Page 1
CDK8-Novel Therapeutic Opportunities.
Menzl I, Witalisz-Siepracka A, Sexl V. Menzl I, et al. Pharmaceuticals (Basel). 2019 Jun 19;12(2):92. doi: 10.3390/ph12020092. Pharmaceuticals (Basel). 2019. PMID: 31248103 Free PMC article. Review.
Recent evidence supports the idea that cyclin-dependent kinase 8 (CDK8) may represent a potential drug target for breast and prostate cancer, although no CDK8 inhibitors have entered the clinics. As the available inhibitors have been recently reviewed, we focus on t …
Recent evidence supports the idea that cyclin-dependent kinase 8 (CDK8) may represent a potential drug target for breast and prostate …
Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T(reg) cells by inhibition of CDK8/19.
Akamatsu M, Mikami N, Ohkura N, Kawakami R, Kitagawa Y, Sugimoto A, Hirota K, Nakamura N, Ujihara S, Kurosaki T, Hamaguchi H, Harada H, Xia G, Morita Y, Aramori I, Narumiya S, Sakaguchi S. Akamatsu M, et al. Sci Immunol. 2019 Oct 25;4(40):eaaw2707. doi: 10.1126/sciimmunol.aaw2707. Sci Immunol. 2019. PMID: 31653719
Here, we show that chemical inhibition of the cyclin-dependent kinase 8 (CDK8) and CDK19, or knockdown/knockout of the CDK8 or CDK19 gene, is able to induce Foxp3, a key transcription factor controlling T(reg) cell function, in antigen-stimulated effector/memory as …
Here, we show that chemical inhibition of the cyclin-dependent kinase 8 (CDK8) and CDK19, or knockdown/knockout of the CDK8 or …
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB. Chen M, et al. Nucleic Acids Res. 2023 Aug 11;51(14):7288-7313. doi: 10.1093/nar/gkad538. Nucleic Acids Res. 2023. PMID: 37378433 Free PMC article.
This analysis was performed using genetic modifications of CDK8 and CDK19, selective CDK8/19 small molecule kinase inhibitors and a potent CDK8/19 PROTAC degrader. ...Analysis of isogenic cell populations expressing CDK8, CDK19 or their kinase-inactive …
This analysis was performed using genetic modifications of CDK8 and CDK19, selective CDK8/19 small molecule kinase inhibitors …
Angel or Devil ? - CDK8 as the new drug target.
Wu D, Zhang Z, Chen X, Yan Y, Liu X. Wu D, et al. Eur J Med Chem. 2021 Mar 5;213:113043. doi: 10.1016/j.ejmech.2020.113043. Epub 2020 Nov 24. Eur J Med Chem. 2021. PMID: 33257171 Review.
Therefore, CDK8 is regarded as a promising target for cancer therapy. Most studies in recent years supported the role of CDK8 as a carcinogen, however, under certain conditions, CDK8 exists as a tumor suppressor. The functional diversity of CDK8 and it …
Therefore, CDK8 is regarded as a promising target for cancer therapy. Most studies in recent years supported the role of CDK8 …
Binding patterns and structure-activity relationship of CDK8 inhibitors.
Ma D, Chen X, Shen XB, Sheng LQ, Liu XH. Ma D, et al. Bioorg Chem. 2020 Mar;96:103624. doi: 10.1016/j.bioorg.2020.103624. Epub 2020 Jan 25. Bioorg Chem. 2020. PMID: 32078847 Review.
The crystal structure of CDK8 has been reported, and eutectic interactions have been identified for 24 compounds that target CDK8. To more effectively develop CDK8 inhibitors, particularly those with improved selectivity, we summarized the structure, structur …
The crystal structure of CDK8 has been reported, and eutectic interactions have been identified for 24 compounds that target CDK8 …
CDK8 kinase--An emerging target in targeted cancer therapy.
Rzymski T, Mikula M, Wiklik K, Brzózka K. Rzymski T, et al. Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1617-29. doi: 10.1016/j.bbapap.2015.05.011. Epub 2015 May 22. Biochim Biophys Acta. 2015. PMID: 26006748 Review.
Structural features of CDK8 and available ligands were discussed from a perspective of the rational drug design process. Current state of the art confirms that further development of CDK8 inhibitors will translate into targeted therapies in oncology. ...
Structural features of CDK8 and available ligands were discussed from a perspective of the rational drug design process. Current stat …
CDK8: a positive regulator of transcription.
Galbraith MD, Donner AJ, Espinosa JM. Galbraith MD, et al. Transcription. 2010 Jul-Aug;1(1):4-12. doi: 10.4161/trns.1.1.12373. Transcription. 2010. PMID: 21327159 Free PMC article. Review.
CDK8 associates with the Mediator complex, but functions outside of Mediator are also likely. Historically, CDK8 has been described mostly as a transcriptional repressor, but a growing body of research provides unequivocal evidence for various roles of CDK8 i …
CDK8 associates with the Mediator complex, but functions outside of Mediator are also likely. Historically, CDK8 has been desc …
Cdk8 Kinase Module: A Mediator of Life and Death Decisions in Times of Stress.
Friedson B, Cooper KF. Friedson B, et al. Microorganisms. 2021 Oct 15;9(10):2152. doi: 10.3390/microorganisms9102152. Microorganisms. 2021. PMID: 34683473 Free PMC article. Review.
The Cdk8 kinase module (CKM) of the multi-subunit mediator complex plays an essential role in cell fate decisions in response to different environmental cues. In the budding yeast S. cerevisiae, the CKM consists of four conserved subunits (cyclin C and its cognate cyclin-d …
The Cdk8 kinase module (CKM) of the multi-subunit mediator complex plays an essential role in cell fate decisions in response to diff …
Regulatory functions of the Mediator kinases CDK8 and CDK19.
Fant CB, Taatjes DJ. Fant CB, et al. Transcription. 2019 Apr;10(2):76-90. doi: 10.1080/21541264.2018.1556915. Epub 2018 Dec 26. Transcription. 2019. PMID: 30585107 Free PMC article. Review.
The Mediator-associated kinases CDK8 and CDK19 function in the context of three additional proteins: CCNC and MED12, which activate CDK8/CDK19 kinase function, and MED13, which enables their association with the Mediator complex. ...We focus on sequence-specific, DN …
The Mediator-associated kinases CDK8 and CDK19 function in the context of three additional proteins: CCNC and MED12, which activate …
CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
Xi M, Chen T, Wu C, Gao X, Wu Y, Luo X, Du K, Yu L, Cai T, Shen R, Sun H. Xi M, et al. Eur J Med Chem. 2019 Feb 15;164:77-91. doi: 10.1016/j.ejmech.2018.11.076. Epub 2018 Dec 21. Eur J Med Chem. 2019. PMID: 30594029 Review.
CDK8 acts as an oncogene and represents a potential target for developing novel CDK8 inhibitors in cancer therapeutics. ...In this review, we summarize co-crystal structures, biological mechanisms, dysregulation in cancers and recent progress in the field of CDK8 …
CDK8 acts as an oncogene and represents a potential target for developing novel CDK8 inhibitors in cancer therapeutics. ...In …
639 results