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Cdyl2-60aa encoded by CircCDYL2 accelerates cardiomyocyte death by blocking APAF1 ubiquitination in rats.
Deng Y, Zeng X, Lv Y, Qian Z, Guo P, Liu Y, Chen S. Deng Y, et al. Exp Mol Med. 2023 Apr;55(4):860-869. doi: 10.1038/s12276-023-00983-5. Epub 2023 Apr 3. Exp Mol Med. 2023. PMID: 37009805 Free PMC article.
Herein, we found that circCDYL2 (583 nt) derived from chromodomain Y-like 2 (Cdyl2) is significantly upregulated in vitro (oxygen-glucose deprivation (OGD)-treated CMs) and in vivo (failing heart post-MI) and can be translated into a polypeptide termed Cdyl2-60aa (~ …
Herein, we found that circCDYL2 (583 nt) derived from chromodomain Y-like 2 (Cdyl2) is significantly upregulated in vitro (oxygen-glu …
CDYL2 Epigenetically Regulates MIR124 to Control NF-kappaB/STAT3-Dependent Breast Cancer Cell Plasticity.
Siouda M, Dujardin AD, Barbollat-Boutrand L, Mendoza-Parra MA, Gibert B, Ouzounova M, Bouaoud J, Tonon L, Robert M, Foy JP, Lavergne V, Manie SN, Viari A, Puisieux A, Ichim G, Gronemeyer H, Saintigny P, Mulligan P. Siouda M, et al. iScience. 2020 Jun 26;23(6):101141. doi: 10.1016/j.isci.2020.101141. Epub 2020 May 6. iScience. 2020. PMID: 32450513 Free PMC article.
We found that the uncharacterized epigenetic factor chromodomain on Y-like 2 (CDYL2) is commonly over-expressed in breast cancer, and that high CDYL2 levels correlate with poor prognosis. ...This, in turn, was downstream of CDYL2 regulation of MIR124 gene tra …
We found that the uncharacterized epigenetic factor chromodomain on Y-like 2 (CDYL2) is commonly over-expressed in breast cancer, and …
STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.
Chen X, Wang Z, Zhao X, Zhang L, Zhou L, Li X, Ge C, Zhao F, Chen T, Xie H, Cui Y, Tian H, Li H, Yao M, Li J. Chen X, et al. Oncogene. 2022 Apr;41(17):2492-2504. doi: 10.1038/s41388-022-02273-2. Epub 2022 Mar 21. Oncogene. 2022. PMID: 35314791
Here, we observed that CDYL2 was down-regulated in human primary HCC tissues and the low levels of CDYL2 expression were correlated with poor survival. ...Collectively, we propose a model for a STAT5A/CDYL2/SLC7A6 axis that provides novel insight into CDYL …
Here, we observed that CDYL2 was down-regulated in human primary HCC tissues and the low levels of CDYL2 expression were corre …
Chromodomain on Y-like 2 (CDYL2) implicated in mitosis and genome stability regulation via interaction with CHAMP1 and POGZ.
Siouda M, Dujardin AD, Dekeyzer B, Schaeffer L, Mulligan P. Siouda M, et al. Cell Mol Life Sci. 2023 Jan 20;80(2):47. doi: 10.1007/s00018-022-04659-7. Cell Mol Life Sci. 2023. PMID: 36658409 Free PMC article.
RNAi rescue assays identified both the CDYL2 chromodomain and the CHAMP1-POGZ interacting region as required and, together, sufficient for CDYL2 regulation of mitosis and genome stability. CDYL2 RNAi caused loss of CHAMP1 localization at pericentromeres. ...
RNAi rescue assays identified both the CDYL2 chromodomain and the CHAMP1-POGZ interacting region as required and, together, sufficien …
Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis.
Yang LF, Yang F, Zhang FL, Xie YF, Hu ZX, Huang SL, Shao ZM, Li DQ. Yang LF, et al. Theranostics. 2020 Apr 6;10(12):5242-5258. doi: 10.7150/thno.43744. eCollection 2020. Theranostics. 2020. PMID: 32373210 Free PMC article.
Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. However, whether CDYL2 is involved in breast cancer progression remains unknown. ...The effect of CDYL2 transcript variants on the malignant phenotypes o …
Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. However, whether CDYL2 …
Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min J. Dong C, et al. Cell Chem Biol. 2020 Jul 16;27(7):827-838.e7. doi: 10.1016/j.chembiol.2020.05.007. Epub 2020 May 28. Cell Chem Biol. 2020. PMID: 32470319 Free article.
Here, we present the structural basis for selective binding of CDY1 to H3K9me3 and preferential binding of CDYL2 to H3tK27me3 over H3K27me3. In addition, we use a CDYL1/2-selective compound, UNC4850, to gain further insight into the molecular mechanisms underlying CDYL2 …
Here, we present the structural basis for selective binding of CDY1 to H3K9me3 and preferential binding of CDYL2 to H3tK27me3 over H3 …
Molecular characterization of the bovine chromodomain Y-like genes.
Wang A, Yasue H, Li L, Takashima M, de León FA, Liu WS. Wang A, et al. Anim Genet. 2008 Jun;39(3):207-16. doi: 10.1111/j.1365-2052.2008.01706.x. Epub 2008 Mar 20. Anim Genet. 2008. PMID: 18371128
The human chromodomain protein, Y-like (CDYL) gene family consists of three members, one on the Y chromosome (CDY) and two on autosomes (CDYL and CDYL2). Studies in the human and mouse showed that genes in the CDYL family are abundantly expressed in testis and play an impo …
The human chromodomain protein, Y-like (CDYL) gene family consists of three members, one on the Y chromosome (CDY) and two on autosomes (CDY …
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library.
Shell DJ, Rectenwald JM, Buttery PH, Johnson RL, Foley CA, Guduru SKR, Uguen M, Rubiano JS, Zhang X, Li F, Norris-Drouin JL, Axtman M, Brian Hardy P, Vedadi M, Frye SV, James LI, Pearce KH. Shell DJ, et al. SLAS Discov. 2022 Dec;27(8):428-439. doi: 10.1016/j.slasd.2022.10.003. Epub 2022 Oct 19. SLAS Discov. 2022. PMID: 36272689 Free article.
To broadly assess the applicability of our library, UNCDEL003 was screened against five diverse Kme reader protein domains (53BP1 TTD, KDM7B JmjC-PHD, CDYL2 CD, CBX2 CD, and LEDGF PWWP) with varying structures and functions. ...
To broadly assess the applicability of our library, UNCDEL003 was screened against five diverse Kme reader protein domains (53BP1 TTD, KDM7B …
Gene expression effects of lithium and valproic acid in a serotonergic cell line.
Balasubramanian D, Pearson JF, Kennedy MA. Balasubramanian D, et al. Physiol Genomics. 2019 Feb 1;51(2):43-50. doi: 10.1152/physiolgenomics.00069.2018. Epub 2018 Dec 21. Physiol Genomics. 2019. PMID: 30576260
., odds ratio of 2, at false discovery rate <5%), but only two genes ( Dynlrb2 and Cdyl2) showed significant differential regulation after exposure of the cells to lithium, with the same analysis criteria. ...
., odds ratio of 2, at false discovery rate <5%), but only two genes ( Dynlrb2 and Cdyl2) showed significant differential regulati …
G9a regulates tumorigenicity and stemness through genome-wide DNA methylation reprogramming in non-small cell lung cancer.
Pangeni RP, Yang L, Zhang K, Wang J, Li W, Guo C, Yun X, Sun T, Wang J, Raz DJ. Pangeni RP, et al. Clin Epigenetics. 2020 Jun 17;12(1):88. doi: 10.1186/s13148-020-00879-5. Clin Epigenetics. 2020. PMID: 32552834 Free PMC article.
RESULTS: We identified 67 genes hypomethylated and 143 genes upregulated following G9A knockdown of which 43 genes were both hypomethylated and upregulated. We selected six genes (CDYL2, DPP4, SP5, FOXP1, STAMBPL1, and ROBO1) for validation. In addition, G9A expression was …
RESULTS: We identified 67 genes hypomethylated and 143 genes upregulated following G9A knockdown of which 43 genes were both hypomethylated …
20 results