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Page 1
Cdyl2-60aa encoded by CircCDYL2 accelerates cardiomyocyte death by blocking APAF1 ubiquitination in rats.
Deng Y, Zeng X, Lv Y, Qian Z, Guo P, Liu Y, Chen S. Deng Y, et al. Exp Mol Med. 2023 Apr;55(4):860-869. doi: 10.1038/s12276-023-00983-5. Epub 2023 Apr 3. Exp Mol Med. 2023. PMID: 37009805 Free PMC article.
Herein, we found that circCDYL2 (583 nt) derived from chromodomain Y-like 2 (Cdyl2) is significantly upregulated in vitro (oxygen-glucose deprivation (OGD)-treated CMs) and in vivo (failing heart post-MI) and can be translated into a polypeptide termed Cdyl2-60aa (~ …
Herein, we found that circCDYL2 (583 nt) derived from chromodomain Y-like 2 (Cdyl2) is significantly upregulated in vitro (oxygen-glu …
CDYL2 Epigenetically Regulates MIR124 to Control NF-kappaB/STAT3-Dependent Breast Cancer Cell Plasticity.
Siouda M, Dujardin AD, Barbollat-Boutrand L, Mendoza-Parra MA, Gibert B, Ouzounova M, Bouaoud J, Tonon L, Robert M, Foy JP, Lavergne V, Manie SN, Viari A, Puisieux A, Ichim G, Gronemeyer H, Saintigny P, Mulligan P. Siouda M, et al. iScience. 2020 Jun 26;23(6):101141. doi: 10.1016/j.isci.2020.101141. Epub 2020 May 6. iScience. 2020. PMID: 32450513 Free PMC article.
We found that the uncharacterized epigenetic factor chromodomain on Y-like 2 (CDYL2) is commonly over-expressed in breast cancer, and that high CDYL2 levels correlate with poor prognosis. ...This, in turn, was downstream of CDYL2 regulation of MIR124 gene tra …
We found that the uncharacterized epigenetic factor chromodomain on Y-like 2 (CDYL2) is commonly over-expressed in breast cancer, and …
STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.
Chen X, Wang Z, Zhao X, Zhang L, Zhou L, Li X, Ge C, Zhao F, Chen T, Xie H, Cui Y, Tian H, Li H, Yao M, Li J. Chen X, et al. Oncogene. 2022 Apr;41(17):2492-2504. doi: 10.1038/s41388-022-02273-2. Epub 2022 Mar 21. Oncogene. 2022. PMID: 35314791
Here, we observed that CDYL2 was down-regulated in human primary HCC tissues and the low levels of CDYL2 expression were correlated with poor survival. ...Consistently, CDYL2 expression correlated significantly with STAT5A and SLC7A6 expression in HCC. Collec …
Here, we observed that CDYL2 was down-regulated in human primary HCC tissues and the low levels of CDYL2 expression were corre …
Chromodomain on Y-like 2 (CDYL2) implicated in mitosis and genome stability regulation via interaction with CHAMP1 and POGZ.
Siouda M, Dujardin AD, Dekeyzer B, Schaeffer L, Mulligan P. Siouda M, et al. Cell Mol Life Sci. 2023 Jan 20;80(2):47. doi: 10.1007/s00018-022-04659-7. Cell Mol Life Sci. 2023. PMID: 36658409 Free PMC article.
Mass spectrometry analysis of CDYL2-interacting proteins identified the neurodevelopmental disease-linked mitotic regulators CHAMP1 and POGZ, which are associated with a central non-conserved region of CDYL2. RNAi rescue assays identified both the CDYL2 chrom …
Mass spectrometry analysis of CDYL2-interacting proteins identified the neurodevelopmental disease-linked mitotic regulators CHAMP1 a …
Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis.
Yang LF, Yang F, Zhang FL, Xie YF, Hu ZX, Huang SL, Shao ZM, Li DQ. Yang LF, et al. Theranostics. 2020 Apr 6;10(12):5242-5258. doi: 10.7150/thno.43744. eCollection 2020. Theranostics. 2020. PMID: 32373210 Free PMC article.
Rationale: Chromodomain Y-like 2 (CDYL2) is a member of the CDY gene family involved in spermatogenesis, but its role in human cancer has not been reported. Analyses of publicly available databases demonstrate that CDYL2 is abundantly expressed in breast tumors. How …
Rationale: Chromodomain Y-like 2 (CDYL2) is a member of the CDY gene family involved in spermatogenesis, but its role in human cancer …
Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min J. Dong C, et al. Cell Chem Biol. 2020 Jul 16;27(7):827-838.e7. doi: 10.1016/j.chembiol.2020.05.007. Epub 2020 May 28. Cell Chem Biol. 2020. PMID: 32470319 Free article.
Here, we present the structural basis for selective binding of CDY1 to H3K9me3 and preferential binding of CDYL2 to H3tK27me3 over H3K27me3. In addition, we use a CDYL1/2-selective compound, UNC4850, to gain further insight into the molecular mechanisms underlying CDYL2 …
Here, we present the structural basis for selective binding of CDY1 to H3K9me3 and preferential binding of CDYL2 to H3tK27me3 over H3 …
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
Yang SK, Hong M, Oh H, Low HQ, Jung S, Ahn S, Kim Y, Baek J, Lee CH, Kim E, Kim KM, Ye BD, Kim KJ, Park SH, Lee HS, Lee I, Shin HD, Han B, McGovern DP, Liu J, Song K. Yang SK, et al. Gastroenterology. 2016 Dec;151(6):1096-1099.e4. doi: 10.1053/j.gastro.2016.08.025. Epub 2016 Aug 26. Gastroenterology. 2016. PMID: 27569725
We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 10(-4)). ...
We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 …
Molecular characterization of the bovine chromodomain Y-like genes.
Wang A, Yasue H, Li L, Takashima M, de León FA, Liu WS. Wang A, et al. Anim Genet. 2008 Jun;39(3):207-16. doi: 10.1111/j.1365-2052.2008.01706.x. Epub 2008 Mar 20. Anim Genet. 2008. PMID: 18371128
The human chromodomain protein, Y-like (CDYL) gene family consists of three members, one on the Y chromosome (CDY) and two on autosomes (CDYL and CDYL2). Studies in the human and mouse showed that genes in the CDYL family are abundantly expressed in testis and play an impo …
The human chromodomain protein, Y-like (CDYL) gene family consists of three members, one on the Y chromosome (CDY) and two on autosomes (CDY …
The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.
Dorus S, Gilbert SL, Forster ML, Barndt RJ, Lahn BT. Dorus S, et al. Hum Mol Genet. 2003 Jul 15;12(14):1643-50. doi: 10.1093/hmg/ddg185. Hum Mol Genet. 2003. PMID: 12837688
This progenitor later duplicated to generate CDYL and CDYL2, two autosomal genes found in all extant mammals. Prior to human-mouse divergence (and perhaps preceding the eutherian radiation), a processed CDYL transcript retroposed onto the Y chromosome to create CDY, the Y- …
This progenitor later duplicated to generate CDYL and CDYL2, two autosomal genes found in all extant mammals. Prior to human-mouse di …
Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing.
Barnash KD, Lamb KN, Stuckey JI, Norris JL, Cholensky SH, Kireev DB, Frye SV, James LI. Barnash KD, et al. ACS Chem Biol. 2016 Sep 16;11(9):2475-83. doi: 10.1021/acschembio.6b00415. Epub 2016 Jul 14. ACS Chem Biol. 2016. PMID: 27356154 Free PMC article.
These selectivity challenges are exemplified by the Polycomb repressive complex 1 (PRC1) chemical probe, UNC3866, which demonstrates submicromolar off-target affinity toward the non-PRC1 chromodomains CDYL2 and CDYL. Moreover, since peptidomimetics are challenging subjects …
These selectivity challenges are exemplified by the Polycomb repressive complex 1 (PRC1) chemical probe, UNC3866, which demonstrates submicr …
20 results