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Page 1
CELF1 promotes matrix metalloproteinases gene expression at transcriptional level in lens epithelial cells.
Xiao J, Tian X, Jin S, He Y, Song M, Zou H. Xiao J, et al. BMC Ophthalmol. 2022 Mar 14;22(1):122. doi: 10.1186/s12886-022-02344-8. BMC Ophthalmol. 2022. PMID: 35287612 Free PMC article.
This finding was also validated by RT-qPCR and public mouse early embryonic lens data. Integrating analysis with public CELF1-RNA interactome data revealed that no obvious CELF1-binding peak was found on the transcripts of these genes, indicating an indirectly regul …
This finding was also validated by RT-qPCR and public mouse early embryonic lens data. Integrating analysis with public CELF1-RNA int …
CELF1 represses Doublesex1 expression via its 5' UTR in the crustacean Daphnia magna.
Tirta YK, Adachi S, Perez CAG, Adhitama N, Nong QD, Natsume T, Kato Y, Watanabe H. Tirta YK, et al. PLoS One. 2022 Oct 14;17(10):e0275526. doi: 10.1371/journal.pone.0275526. eCollection 2022. PLoS One. 2022. PMID: 36240182 Free PMC article.
Here we report the CELF1-dependent suppression of Dsx1 expression in D. magna. During embryogenesis, CELF1 expression was not sexually dimorphic. ...Overexpression of CELF1 in male embryos resulted in a reduction of Dsx1 expression. ...
Here we report the CELF1-dependent suppression of Dsx1 expression in D. magna. During embryogenesis, CELF1 expression was not …
Alzheimer's disease risk genes and mechanisms of disease pathogenesis.
Karch CM, Goate AM. Karch CM, et al. Biol Psychiatry. 2015 Jan 1;77(1):43-51. doi: 10.1016/j.biopsych.2014.05.006. Epub 2014 May 17. Biol Psychiatry. 2015. PMID: 24951455 Free PMC article. Review.
More recent advances in understanding of the human genome-technologic advances in methods to analyze millions of polymorphisms in thousands of subjects-have revealed new genes associated with AD risk, including ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, …
More recent advances in understanding of the human genome-technologic advances in methods to analyze millions of polymorphisms in thousands …
CELF1 Selectively Regulates Alternative Splicing of DNA Repair Genes Associated With Cataract in Human Lens Cell Line.
Xiao J, Jin S, Wang X, Huang J, Zou H. Xiao J, et al. Biochem Genet. 2023 Aug;61(4):1319-1333. doi: 10.1007/s10528-022-10324-2. Epub 2022 Dec 30. Biochem Genet. 2023. PMID: 36585568
We finally identified 840 CELF1-regulated AS events (RASEs) and found that CELF1-OE preferred to repress exon skipping events in SRA01/04 cells. ...We found that 194 genes were bound and regulated by CELF1 at the AS level. 10 genes involved in DNA repair-rela …
We finally identified 840 CELF1-regulated AS events (RASEs) and found that CELF1-OE preferred to repress exon skipping events …
CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure.
Chang KT, Wang LH, Lin YM, Cheng CF, Wang GS. Chang KT, et al. FASEB J. 2021 May;35(5):e21512. doi: 10.1096/fj.202002553R. FASEB J. 2021. PMID: 33811692
In the present study, we investigated the role of increased CELF1 expression in causing vascular rarefaction in DCM. CELF1 overexpression (CELF1-OE) in cardiomyocytes resulted in reduced capillary density. ...Also, CELF1 bound to Vegfa mRNA and regulat …
In the present study, we investigated the role of increased CELF1 expression in causing vascular rarefaction in DCM. CELF1 ove …
CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy.
Chang KT, Cheng CF, King PC, Liu SY, Wang GS. Chang KT, et al. Circ Res. 2017 Oct 27;121(10):1140-1152. doi: 10.1161/CIRCRESAHA.117.311281. Epub 2017 Sep 5. Circ Res. 2017. PMID: 28874395
OBJECTIVE: We investigated the mechanism of CELF1-mediated Cx43 mRNA degradation and determined whether elevated CELF1 expression is also a shared feature of the DCM heart. ...With knockdown of endogenous RRP6, CELF1 failed to downregulate Cx43 mRNA, which su …
OBJECTIVE: We investigated the mechanism of CELF1-mediated Cx43 mRNA degradation and determined whether elevated CELF1 express …
CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
Yan JK, Zhang T, Dai LN, Gu BL, Zhu J, Yan WH, Cai W, Wang Y. Yan JK, et al. FASEB J. 2019 Mar;33(3):3378-3391. doi: 10.1096/fj.201801695R. Epub 2018 Dec 4. FASEB J. 2019. PMID: 30514107
By using a rat model of TPN, we found synchronous upregulation of CELF1 and p53 in jejunum mucosa, accompanied by a 51% decrease in crypt cell proliferation rate. ...Furthermore, ectopic overexpression of CELF1 elicited a significant antiproliferative effect in HCT- …
By using a rat model of TPN, we found synchronous upregulation of CELF1 and p53 in jejunum mucosa, accompanied by a 51% decrease in c …
Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis.
Tan Y, Sun X, Xu Y, Tang B, Xu S, Lu D, Ye Y, Luo X, Diao X, Li F, Wang T, Chen J, Xu Q, Wu X. Tan Y, et al. Nucleic Acids Res. 2022 Mar 21;50(5):2440-2451. doi: 10.1093/nar/gkac139. Nucleic Acids Res. 2022. PMID: 35234905 Free PMC article.
However, targeting CELF1 is still a challenge, as RBPs are considered largely undruggable. ...Compound 27 binds directly to CELF1 and competes with RNA for binding to CELF1. Compound 27 promotes IFN-gamma secretion and suppresses TGF-beta1-induced hepatic ste …
However, targeting CELF1 is still a challenge, as RBPs are considered largely undruggable. ...Compound 27 binds directly to CELF1 …
RNA-binding protein CELF1 promotes cardiac hypertrophy via interaction with PEBP1 in cardiomyocytes.
Hu X, Wu P, Liu B, Lang Y, Li T. Hu X, et al. Cell Tissue Res. 2022 Jan;387(1):111-121. doi: 10.1007/s00441-021-03541-5. Epub 2021 Oct 20. Cell Tissue Res. 2022. PMID: 34669021
RNA immunoprecipitation revealed that CELF1 directly interacted with PEBP1 mRNA. Biotin pull-down analysis and dual-luciferase assay showed that CELF1 directly bound to the fragment 1 within 3'UTR of PEBP1. Moreover, knockdown of PEBP1 partially enhanced the product …
RNA immunoprecipitation revealed that CELF1 directly interacted with PEBP1 mRNA. Biotin pull-down analysis and dual-luciferase assay …
CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart.
Belanger K, Nutter CA, Li J, Tasnim S, Liu P, Yu P, Kuyumcu-Martinez MN. Belanger K, et al. Biochem Biophys Res Commun. 2018 Sep 18;503(4):3205-3211. doi: 10.1016/j.bbrc.2018.08.126. Epub 2018 Aug 27. Biochem Biophys Res Commun. 2018. PMID: 30158053 Free PMC article.
We discovered that many aberrantly spliced genes in T1D hearts have CELF1 binding sites. CELF1-regulated AS affects key genes within signaling pathways relevant to diabetes pathogenesis. Disruption of CELF1 binding sites impairs AS regulation by CELF1. …
We discovered that many aberrantly spliced genes in T1D hearts have CELF1 binding sites. CELF1-regulated AS affects key genes …
309 results