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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 3
2004 1
2005 2
2006 1
2007 3
2008 4
2009 4
2010 10
2011 10
2012 14
2013 16
2014 19
2015 25
2016 11
2017 11
2018 19
2019 14
2020 9
2021 19
2022 18
2023 14
2024 8

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205 results

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Page 1
IL-10 constrains sphingolipid metabolism to limit inflammation.
York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. York AG, et al. Nature. 2024 Mar;627(8004):628-635. doi: 10.1038/s41586-024-07098-5. Epub 2024 Feb 21. Nature. 2024. PMID: 38383790 Free PMC article.
Accordingly, genetic deletion of ceramide synthase 2 (encoded by Cers2), the enzyme responsible for VLC ceramide production, limited the exacerbated inflammatory gene expression programme associated with IL-10 deficiency both in vitro and in vivo. ...
Accordingly, genetic deletion of ceramide synthase 2 (encoded by Cers2), the enzyme responsible for VLC ceramide production, limited …
Evaluation of CERS2 Gene as a Potential Biomarker for Bladder Cancer.
Aldoghachi AF, Baharudin A, Ahmad U, Chan SC, Ong TA, Yunus R, Razack AH, Yusoff K, Veerakumarasivam A. Aldoghachi AF, et al. Dis Markers. 2019 Sep 15;2019:3875147. doi: 10.1155/2019/3875147. eCollection 2019. Dis Markers. 2019. PMID: 31636736 Free PMC article.
The potential utility of CERS2 as a predictive biomarker of response to oncolytic virotherapy was assessed by correlating the CERS2 mRNA expression to IC(50) values of cells treated with the Newcastle disease virus (NDV), AF2240 strain. ...However, there were no sig …
The potential utility of CERS2 as a predictive biomarker of response to oncolytic virotherapy was assessed by correlating the CERS …
Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study.
Nicholson RJ, Poss AM, Maschek JA, Cox JE, Hopkins PN, Hunt SC, Playdon MC, Holland WL, Summers SA. Nicholson RJ, et al. J Clin Endocrinol Metab. 2021 Jul 13;106(8):e3098-e3109. doi: 10.1210/clinem/dgab155. J Clin Endocrinol Metab. 2021. PMID: 33705551 Free PMC article.
OBJECTIVE: The studies described herein aimed to characterize the effects of rs267738 on CERS2 enzyme activity, sphingolipid profiles, and metabolic outcomes. ...Homozygous knock-in mice had reduced liver CERS2 activity and enhanced diet-induced glucose intolerance …
OBJECTIVE: The studies described herein aimed to characterize the effects of rs267738 on CERS2 enzyme activity, sphingolipid profiles …
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.
Fan SH, Wang YY, Lu J, Zheng YL, Wu DM, Zhang ZF, Shan Q, Hu B, Li MQ, Cheng W. Fan SH, et al. J Cell Biochem. 2015 Apr;116(4):502-13. doi: 10.1002/jcb.24978. J Cell Biochem. 2015. PMID: 25213553
Ceramide synthase 2 (CERS2) is the gene identified from a human liver cDNA library in 2001. ...However, the molecular mechanism of CERS2 involved is unknown. Here, we found CERS2 was heterogeneously expressed in various breast cancer cells. ...
Ceramide synthase 2 (CERS2) is the gene identified from a human liver cDNA library in 2001. ...However, the molecular mechanism of …
CerS2 haploinsufficiency inhibits beta-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA. Raichur S, et al. Cell Metab. 2014 Oct 7;20(4):687-95. doi: 10.1016/j.cmet.2014.09.015. Cell Metab. 2014. PMID: 25295789 Free article.
Six different ceramide synthases (CerS) that differ in tissue distribution and substrate specificity account for the diversity in acyl-chain composition of distinct ceramide species. Haploinsufficiency for ceramide synthase 2 (CerS2), the dominant isoform in the liver that …
Six different ceramide synthases (CerS) that differ in tissue distribution and substrate specificity account for the diversity in acyl-chain …
Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.
Spassieva SD, Mullen TD, Townsend DM, Obeid LM. Spassieva SD, et al. Biochem J. 2009 Nov 11;424(2):273-83. doi: 10.1042/BJ20090699. Biochem J. 2009. PMID: 19728861 Free PMC article.
C24, C24:1. To study the role of CerS2 in ceramide metabolism and cellular homoeostasis, we down-regulated CerS2 using siRNA (small interfering RNA) and examined several aspects of sphingolipid metabolism and cell stress responses. CerS2 down-regulation had a …
C24, C24:1. To study the role of CerS2 in ceramide metabolism and cellular homoeostasis, we down-regulated CerS2 using siRNA ( …
205 results