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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R. Kuhn A, et al. Among authors: cha jh. Hum Mol Genet. 2007 Aug 1;16(15):1845-61. doi: 10.1093/hmg/ddm133. Epub 2007 May 21. Hum Mol Genet. 2007. PMID: 17519223
Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.
Benn CL, Luthi-Carter R, Kuhn A, Sadri-Vakili G, Blankson KL, Dalai SC, Goldstein DR, Spires TL, Pritchard J, Olson JM, van Dellen A, Hannan AJ, Cha JH. Benn CL, et al. Among authors: cha jh. J Neuropathol Exp Neurol. 2010 Aug;69(8):817-27. doi: 10.1097/NEN.0b013e3181ea167f. J Neuropathol Exp Neurol. 2010. PMID: 20613636
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease.
Luthi-Carter R, Strand A, Peters NL, Solano SM, Hollingsworth ZR, Menon AS, Frey AS, Spektor BS, Penney EB, Schilling G, Ross CA, Borchelt DR, Tapscott SJ, Young AB, Cha JH, Olson JM. Luthi-Carter R, et al. Among authors: cha jh. Hum Mol Genet. 2000 May 22;9(9):1259-71. doi: 10.1093/hmg/9.9.1259. Hum Mol Genet. 2000. PMID: 10814708
Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation.
Luthi-Carter R, Apostol BL, Dunah AW, DeJohn MM, Farrell LA, Bates GP, Young AB, Standaert DG, Thompson LM, Cha JH. Luthi-Carter R, et al. Among authors: cha jh. Neurobiol Dis. 2003 Dec;14(3):624-36. doi: 10.1016/j.nbd.2003.08.024. Neurobiol Dis. 2003. PMID: 14678777
666 results