Chan NL - Search Results

1

Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones.

Tang H, Tang Y, Kurnikov IV, Liao HJ, Chan NL, Kurnikova MG, Guo Y, Chang WC. Tang H, et al. Among authors: chan nl. ACS Catal. 2021 Jun 18;11(12):7186-7192. doi: 10.1021/acscatal.1c01150. Epub 2021 Jun 6. ACS Catal. 2021. PMID: 35721870 Free PMC article.

2

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation.

Liao HJ, Li J, Huang JL, Davidson M, Kurnikov I, Lin TS, Lee JL, Kurnikova M, Guo Y, Chan NL, Chang WC. Liao HJ, et al. Among authors: chan nl. Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1831-1835. doi: 10.1002/anie.201710567. Epub 2018 Jan 16. Angew Chem Int Ed Engl. 2018. PMID: 29314482

3

Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate.

Li J, Liao HJ, Tang Y, Huang JL, Cha L, Lin TS, Lee JL, Kurnikov IV, Kurnikova MG, Chang WC, Chan NL, Guo Y. Li J, et al. Among authors: chan nl. J Am Chem Soc. 2020 Apr 1;142(13):6268-6284. doi: 10.1021/jacs.0c00484. Epub 2020 Mar 16. J Am Chem Soc. 2020. PMID: 32131594 Free PMC article.

4

Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase.

Tang H, Wu MH, Lin HY, Han MR, Tu YH, Yang ZJ, Chien TC, Chan NL, Chang WC. Tang H, et al. Among authors: chan nl. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2113770119. doi: 10.1073/pnas.2113770119. Proc Natl Acad Sci U S A. 2022. PMID: 34969844 Free PMC article.

5

Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 Helicase.

Yu CC, Lin PC, Chiang CH, Jen ST, Lai YL, Hsu SC, Lo LC, Lin JJ, Chan NL, Yu MJ. Yu CC, et al. Among authors: chan nl. J Virol. 2022 Apr 13;96(7):e0010722. doi: 10.1128/jvi.00107-22. Epub 2022 Mar 16. J Virol. 2022. PMID: 35293767 Free PMC article.

6

New insights into DNA-binding by type IIA topoisomerases.

Chang CC, Wang YR, Chen SF, Wu CC, Chan NL. Chang CC, et al. Among authors: chan nl. Curr Opin Struct Biol. 2013 Feb;23(1):125-33. doi: 10.1016/j.sbi.2012.11.011. Epub 2012 Dec 21. Curr Opin Struct Biol. 2013. PMID: 23265999 Review.

7

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.

Wang YR, Chen SF, Wu CC, Liao YW, Lin TS, Liu KT, Chen YS, Li TK, Chien TC, Chan NL. Wang YR, et al. Among authors: chan nl. Nucleic Acids Res. 2017 Oct 13;45(18):10861-10871. doi: 10.1093/nar/gkx742. Nucleic Acids Res. 2017. PMID: 28977631 Free PMC article.

8

Expression, purification, crystallization and preliminary X-ray analysis of the RecQ helicase catalytic core from Deinococcus radiodurans.

Chen SC, Huang CH, Yang CS, Chang CH, Kuan SM, Chan NL, Chen Y. Chen SC, et al. Among authors: chan nl. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1234-6. doi: 10.1107/S1744309112037517. Epub 2012 Sep 29. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 23027755 Free PMC article.

9

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.

Lee YR, Lin TS, Lai SJ, Liu MS, Lai MC, Chan NL. Lee YR, et al. Among authors: chan nl. Sci Rep. 2016 Dec 9;6:38071. doi: 10.1038/srep38071. Sci Rep. 2016. PMID: 27934872 Free PMC article.

10

Expression, purification, crystallization and preliminary X-ray analysis of ribitol-5-phosphate cytidylyltransferase from Bacillus subtilis.

Chen SC, Yang CS, Lin CT, Chan NL, Chang MC, Chen Y. Chen SC, et al. Among authors: chan nl. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1195-7. doi: 10.1107/S1744309112035142. Epub 2012 Sep 26. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 23027746 Free PMC article.

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