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Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.
Wang L, Desmoulin SK, Cherian C, Polin L, White K, Kushner J, Fulterer A, Chang MH, Mitchell-Ryan S, Stout M, Romero MF, Hou Z, Matherly LH, Gangjee A. Wang L, et al. Among authors: chang mh. J Med Chem. 2011 Oct 27;54(20):7150-64. doi: 10.1021/jm200739e. Epub 2011 Sep 22. J Med Chem. 2011. PMID: 21879757 Free PMC article.
Renal physiology of SLC26 anion exchangers.
Sindić A, Chang MH, Mount DB, Romero MF. Sindić A, et al. Among authors: chang mh. Curr Opin Nephrol Hypertens. 2007 Sep;16(5):484-90. doi: 10.1097/MNH.0b013e3282e7d7d0. Curr Opin Nephrol Hypertens. 2007. PMID: 17693766 Review.
Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.
Desmoulin SK, Wang Y, Wu J, Stout M, Hou Z, Fulterer A, Chang MH, Romero MF, Cherian C, Gangjee A, Matherly LH. Desmoulin SK, et al. Among authors: chang mh. Mol Pharmacol. 2010 Oct;78(4):577-87. doi: 10.1124/mol.110.065896. Epub 2010 Jul 2. Mol Pharmacol. 2010. PMID: 20601456 Free PMC article.
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.
Mahadeo K, Diop-Bove N, Shin D, Unal ES, Teo J, Zhao R, Chang MH, Fulterer A, Romero MF, Goldman ID. Mahadeo K, et al. Among authors: chang mh. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1153-61. doi: 10.1152/ajpcell.00113.2010. Epub 2010 Aug 4. Am J Physiol Cell Physiol. 2010. PMID: 20686069 Free PMC article.
1,020 results