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The 5-HT1A receptor: signaling, desensitization, and gene transcription.
Albert PR, Lembo P, Storring JM, Charest A, Saucier C. Albert PR, et al. Among authors: charest a. Neuropsychopharmacology. 1996 Jan;14(1):19-25. doi: 10.1016/S0893-133X(96)80055-8. Neuropsychopharmacology. 1996. PMID: 8719026 Review.
., 5-HT1A agonists, 5-HT uptake blockers) exert their clinical actions via enhancement of serotonergic neurotransmission due to desensitization of 5-HT1A autoreceptors predicts that regulation of this receptor plays a crucial role in the therapeutic actions of these agents …
., 5-HT1A agonists, 5-HT uptake blockers) exert their clinical actions via enhancement of serotonergic neurotransmission due to desensitizat …
Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.
Nguyen L, Holgado-Madruga M, Maroun C, Fixman ED, Kamikura D, Fournier T, Charest A, Tremblay ML, Wong AJ, Park M. Nguyen L, et al. Among authors: charest a. J Biol Chem. 1997 Aug 15;272(33):20811-9. doi: 10.1074/jbc.272.33.20811. J Biol Chem. 1997. PMID: 9252406
Tyrosine 1356 forms a multisubstrate binding site for the Grb2 and Shc adaptor proteins, the p85 subunit of phosphatidylinositol 3'-kinase, phospholipase Cgamma, and a phosphatase, SHP2. ...Association of Gab1 with Met requires a functional Grb2 binding site …
Tyrosine 1356 forms a multisubstrate binding site for the Grb2 and Shc adaptor proteins, the p85 subunit of phosphatidylinositol 3'-k …
TATA-driven transcriptional initiation and regulation of the rat serotonin 5-HT1A receptor gene.
Storring JM, Charest A, Cheng P, Albert PR. Storring JM, et al. Among authors: charest a. J Neurochem. 1999 Jun;72(6):2238-47. doi: 10.1046/j.1471-4159.1999.0722238.x. J Neurochem. 1999. PMID: 10349831
A nonselective enhancer/promoter that mediated expression in all cell lines was located upstream between -1,519 and -426 bp in a DNA segment containing consensus TATA, CCAAT, SP-1, and AP-1 elements as well as a poly-GT26 dinucleotide repeat. ...Our results i
A nonselective enhancer/promoter that mediated expression in all cell lines was located upstream between -1,519 and -426 bp in a
Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2.
Charest A, Wagner J, Kwan M, Tremblay ML. Charest A, et al. Oncogene. 1997 Apr 10;14(14):1643-51. doi: 10.1038/sj.onc.1201008. Oncogene. 1997. PMID: 9135065
In addition, identification of putative substrate(s) of MPTP-PEST have revealed a candidate protein of approximately 120 kDa which is tyrosine phosphorylated upon EGF stimulation. Together, these results describe a novel SH3 domain-dependent recruitment of a
In addition, identification of putative substrate(s) of MPTP-PEST have revealed a candidate protein of approximately 120 kDa which is …
Cloning and differentiation-induced expression of a murine serotonin1A receptor in a septal cell line.
Charest A, Wainer BH, Albert PR. Charest A, et al. J Neurosci. 1993 Dec;13(12):5164-71. doi: 10.1523/JNEUROSCI.13-12-05164.1993. J Neurosci. 1993. PMID: 8254366 Free PMC article.
A neuronal cell model endogenously expressing the 5-HT1A receptor, in which to study the function and regulation of this gene, has yet to be identified. We examined murine SN-48 cells, a septum x neuroblastoma fusion cell line that proliferates in a nondiffer
A neuronal cell model endogenously expressing the 5-HT1A receptor, in which to study the function and regulation of this gene, has ye
Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model.
Côté JF, Charest A, Wagner J, Tremblay ML. Côté JF, et al. Among authors: charest a. Biochemistry. 1998 Sep 22;37(38):13128-37. doi: 10.1021/bi981259l. Biochemistry. 1998. PMID: 9748319
We have generated fibroblast cell lines having a gene-targeted PTP-PEST in order to identify potential substrates with the premise that specific substrates of this enzyme would exist in a hyperphosphorylated state. ...Furthermore, the Cas-like molecules Hef1 and Sin …
We have generated fibroblast cell lines having a gene-targeted PTP-PEST in order to identify potential substrates with the premise th …
Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity.
Charest A, Wagner J, Jacob S, McGlade CJ, Tremblay ML. Charest A, et al. J Biol Chem. 1996 Apr 5;271(14):8424-9. doi: 10.1074/jbc.271.14.8424. J Biol Chem. 1996. PMID: 8626541
We report here the detailed mapping of this interaction in a murine context using glutathione S-transferase fusion protein binding studies and peptide competition assays. ...Since this interaction is not dependent on the presence of a tyrosine-phosphorylated residue …
We report here the detailed mapping of this interaction in a murine context using glutathione S-transferase fusion protein binding st …
Structure of the murine MPTP-PEST gene: genomic organization and chromosomal mapping.
Charest A, Wagner J, Muise ES, Heng HH, Tremblay ML. Charest A, et al. Genomics. 1995 Aug 10;28(3):501-7. doi: 10.1006/geno.1995.1181. Genomics. 1995. PMID: 7490087
Protein tyrosine phosphatases comprise a large family of enzymes that are involved in the control of cellular tyrosine phosphorylation. ...In addition, this analysis reveals a strong conservation of the genomic organization within the catalytic domain of the protein …
Protein tyrosine phosphatases comprise a large family of enzymes that are involved in the control of cellular tyrosine phosphorylatio …
The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation.
Jun HJ, Johnson H, Bronson RT, de Feraudy S, White F, Charest A. Jun HJ, et al. Among authors: charest a. Cancer Res. 2012 Aug 1;72(15):3764-74. doi: 10.1158/0008-5472.CAN-11-3990. Epub 2012 Jun 1. Cancer Res. 2012. PMID: 22659450 Free PMC article.
Patients with lung cancer often present with metastatic disease and therefore have a very poor prognosis. The recent discovery of several novel ROS receptor tyrosine kinase molecular alterations in non-small cell lung cancer (NSCLC) presents a therapeutic opportunit …
Patients with lung cancer often present with metastatic disease and therefore have a very poor prognosis. The recent discovery of sev …
Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts.
Angers-Loustau A, Côté JF, Charest A, Dowbenko D, Spencer S, Lasky LA, Tremblay ML. Angers-Loustau A, et al. Among authors: charest a. J Cell Biol. 1999 Mar 8;144(5):1019-31. doi: 10.1083/jcb.144.5.1019. J Cell Biol. 1999. PMID: 10085298 Free PMC article.
This phenomenon appears to be due in part to a constitutive increase in tyrosine phosphorylation of p130(CAS), a known PTP-PEST substrate, paxillin, which associates with PTP-PEST in vitro, and focal adhesion kinase (FAK). ...In (-/-) cells, we found a signif …
This phenomenon appears to be due in part to a constitutive increase in tyrosine phosphorylation of p130(CAS), a known PTP-PES …
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