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Page 1
Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues.
Singh R, Barrios A, Dirakvand G, Pervin S. Singh R, et al. Cells. 2021 Nov 5;10(11):3030. doi: 10.3390/cells10113030. Cells. 2021. PMID: 34831253 Free PMC article. Review.
Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UC …
Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to …
Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle.
Janovska P, Zouhar P, Bardova K, Otahal J, Vrbacky M, Mracek T, Adamcova K, Lenkova L, Funda J, Cajka T, Drahota Z, Stanic S, Rustan AC, Horakova O, Houstek J, Rossmeisl M, Kopecky J. Janovska P, et al. Mol Metab. 2023 Mar;69:101683. doi: 10.1016/j.molmet.2023.101683. Epub 2023 Jan 30. Mol Metab. 2023. PMID: 36720306 Free PMC article.
OBJECTIVE: Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system in response to cold or diet, contributing to both thermal and energy homeostasis. ...Cold tolerance phenotype of A/ …
OBJECTIVE: Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated v …
KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands.
Fan L, Lesser AF, Sweet DR, Keerthy KS, Lu Y, Chan ER, Vinayachandran V, Ilkayeva O, Das T, Newgard CB, Jain MK. Fan L, et al. iScience. 2022 Oct 8;25(11):105292. doi: 10.1016/j.isci.2022.105292. eCollection 2022 Nov 18. iScience. 2022. PMID: 36304102 Free PMC article.
Brown adipose tissue (BAT) is a specialized metabolic organ responsible for non-shivering thermogenesis. Recently, its activity has been shown to be critical in systemic metabolic health through its utilization and consumption of macronutrients. ...
Brown adipose tissue (BAT) is a specialized metabolic organ responsible for non-shivering thermogenesis. Recently, its activity has b …
Hibernation triggers and cryogens: do they play a role in hibernation?
Vybíral S, Janský L. Vybíral S, et al. Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1125-33. doi: 10.1016/s0300-9629(97)00239-9. Comp Biochem Physiol A Physiol. 1997. PMID: 9505422 Review.
Pharmacological doses of a delta opioid--DADLE (25 or 50 micrograms), when injected into the anterior hypothalamus, induce a small and short-lasting hypothermic effect in cold exposed rabbits, due to the downward shift of the temperature threshold for shivering. Lower dose …
Pharmacological doses of a delta opioid--DADLE (25 or 50 micrograms), when injected into the anterior hypothalamus, induce a small and short …
Evidence of viscerally-mediated cold-defence thermoeffector responses in man.
Morris NB, Filingeri D, Halaki M, Jay O. Morris NB, et al. J Physiol. 2017 Feb 15;595(4):1201-1212. doi: 10.1113/JP273052. Epub 2016 Dec 26. J Physiol. 2017. PMID: 27929204 Free PMC article.
The present study aimed to determine whether visceral thermoreceptors modify shivering responses to cold stress. Ten males (mean SD: age 27 5 years; height 1.73 0.06 m, weight 78.4 10.7 kg) underwent whole-body cooling via a water perfusion suit at 5C, on four occasions, t …
The present study aimed to determine whether visceral thermoreceptors modify shivering responses to cold stress. Ten males (mean SD: …
Sodium regulates clock time and output via an excitatory GABAergic pathway.
Gizowski C, Bourque CW. Gizowski C, et al. Nature. 2020 Jul;583(7816):421-424. doi: 10.1038/s41586-020-2471-x. Epub 2020 Jul 8. Nature. 2020. PMID: 32641825
Here we show that a systemic salt injection (hypertonic saline) given at Zeitgeber time 19-a time at which SCN(VP) (vasopressin) neurons are inactive-excited SCN(VP) neurons and decreased non-shivering thermogenesis (NST) and body temperature. The effects of hypertonic sal …
Here we show that a systemic salt injection (hypertonic saline) given at Zeitgeber time 19-a time at which SCN(VP) (vasopressin) neurons are …
α2-Adrenergic Receptor Agonist, an Attractive but Underused ERAS Component in Improving Fast-Track Recovery and Surgical Outcomes.
Zhang SJ, Lai G, Griffis CA, Schiltz M, Aroke EN. Zhang SJ, et al. AANA J. 2021 Dec;89(6):529-537. AANA J. 2021. PMID: 34809759
Given the wide distribution of alpha(2)-ARs in the body, alpha(2)-AR agonists have been associated with a reduction in anxiety, perioperative stress, inflammation, postoperative nausea and vomiting, shivering, and cognitive dysfunction. This course describes the basic and …
Given the wide distribution of alpha(2)-ARs in the body, alpha(2)-AR agonists have been associated with a reduction in anxiety, perioperativ …
Immune system of cold-exposed and cold-adapted humans.
Janský L, Pospísilová D, Honzová S, Ulicný B, Srámek P, Zeman V, Kamínková J. Janský L, et al. Eur J Appl Physiol Occup Physiol. 1996;72(5-6):445-50. doi: 10.1007/BF00242274. Eur J Appl Physiol Occup Physiol. 1996. PMID: 8925815
It was concluded that the stress-inducing noninfectious stimuli, such as repeated cold water immersions, which increased metabolic rate due to shivering the elevated blood concentrations of catecholamines, activated the immune system to a slight extent. ...
It was concluded that the stress-inducing noninfectious stimuli, such as repeated cold water immersions, which increased metabolic rate due …
Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
Finkel TH, Li J, Wei Z, Wang W, Zhang H, Behrens EM, Reuschel EL, Limou S, Wise C, Punaro M, Becker ML, Munro JE, Flatø B, Førre Ø, Thompson SD, Langefeld CD, Glass DN, Glessner JT, Kim CE, Frackelton E, Shivers DK, Thomas KA, Chiavacci RM, Hou C, Xu K, Snyder J, Qiu H, Mentch F, Wang K, Winkler CA, Lie BA, Ellis JA, Hakonarson H. Finkel TH, et al. BMC Med Genet. 2016 Mar 22;17:24. doi: 10.1186/s12881-016-0285-3. BMC Med Genet. 2016. PMID: 27005825 Free PMC article.
The EMCOOLs surface cooling system for fever control in neurocritical care patients: A pilot study.
Griffiths SA, Ahmad J, Francoeur CL, Gordon E, Dangayach NS, Wheelwright D, Ramineni A, Mayer SA. Griffiths SA, et al. Clin Neurol Neurosurg. 2019 Sep;184:105412. doi: 10.1016/j.clineuro.2019.105412. Epub 2019 Jul 2. Clin Neurol Neurosurg. 2019. PMID: 31323544
Core temperature (bladder) was continuously recorded over 4 h, and the highest Bedside Shivering Assessment Scale (BSAS) score was recorded hourly. RESULTS: Twelve subjects were included in the analysis. ...
Core temperature (bladder) was continuously recorded over 4 h, and the highest Bedside Shivering Assessment Scale (BSAS) score was re …
17 results