Chen EC - Search Results

1

Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice.

Lombana TN, Rajan S, Zorn JA, Mandikian D, Chen EC, Estevez A, Yip V, Bravo DD, Phung W, Farahi F, Viajar S, Lee S, Gill A, Sandoval W, Wang J, Ciferri C, Boswell CA, Matsumoto ML, Spiess C. Lombana TN, et al. Among authors: chen ec. MAbs. 2019 Aug/Sep;11(6):1122-1138. doi: 10.1080/19420862.2019.1622940. Epub 2019 Jun 9. MAbs. 2019. PMID: 31122132 Free PMC article.

2

Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.

Chen EC, Broccatelli F, Plise E, Chen B, Liu L, Cheong J, Zhang S, Jorski J, Gaffney K, Umemoto KK, Salphati L. Chen EC, et al. Among authors: chen b. Mol Pharm. 2018 Nov 5;15(11):5103-5113. doi: 10.1021/acs.molpharmaceut.8b00688. Epub 2018 Oct 10. Mol Pharm. 2018. PMID: 30222362

3

The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.

Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. Morrissey KM, et al. Among authors: chen ec. Clin Pharmacokinet. 2016 Apr;55(4):495-506. doi: 10.1007/s40262-015-0332-9. Clin Pharmacokinet. 2016. PMID: 26507723 Free PMC article.

4

Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case example.

Chen Y, Zhu R, Ma F, Mao J, Chen EC, Choo EF, Sahasranaman S, Liu L. Chen Y, et al. Among authors: chen ec. Biopharm Drug Dispos. 2018 Nov;39(9):420-430. doi: 10.1002/bdd.2159. Epub 2018 Nov 20. Biopharm Drug Dispos. 2018. PMID: 30335192

5

Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse.

Chang JH, Zhang X, Messick K, Chen YC, Chen E, Cheong J, Ly J. Chang JH, et al. Xenobiotica. 2019 May;49(5):602-610. doi: 10.1080/00498254.2018.1478167. Epub 2018 Jun 6. Xenobiotica. 2019. PMID: 29768081

6

Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects.

Liu L, Cheeti S, Yoshida K, Choo E, Chen E, Chen B, Gates M, Singel S, Morley R, Ware J, Sahasranaman S. Liu L, et al. J Clin Pharmacol. 2018 Nov;58(11):1427-1435. doi: 10.1002/jcph.1261. Epub 2018 May 22. J Clin Pharmacol. 2018. PMID: 29786857

7

Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma.

Bowman CM, Chen E, Chen L, Chen YC, Liang X, Wright M, Chen Y, Mao J. Bowman CM, et al. Drug Metab Dispos. 2020 Jan;48(1):18-24. doi: 10.1124/dmd.119.088948. Epub 2019 Nov 7. Drug Metab Dispos. 2020. PMID: 31699807

8

Evaluation of bottom-up modeling of the blood-brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling.

Bowman C, Ma F, Mao J, Plise E, Chen E, Liu L, Zhang S, Chen Y. Bowman C, et al. Biopharm Drug Dispos. 2023 Feb;44(1):60-70. doi: 10.1002/bdd.2344. Epub 2023 Feb 7. Biopharm Drug Dispos. 2023. PMID: 36630933

9

High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.

Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM. Chen EC, et al. Pharm Res. 2022 Jul;39(7):1599-1613. doi: 10.1007/s11095-022-03171-8. Epub 2022 Jan 28. Pharm Res. 2022. PMID: 35089508 Free PMC article.

10

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.

Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X. Giacomini KM, et al. Among authors: chen ec. Clin Pharmacol Ther. 2022 Sep;112(3):540-561. doi: 10.1002/cpt.2627. Epub 2022 May 20. Clin Pharmacol Ther. 2022. PMID: 35488474 Free PMC article. Review.

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