Chen HL - Search Results

1

Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.

Gibson GE, Xu H, Chen HL, Chen W, Denton TT, Zhang S. Gibson GE, et al. Among authors: chen hl, chen w. J Neurochem. 2015 Jul;134(1):86-96. doi: 10.1111/jnc.13096. Epub 2015 Apr 8. J Neurochem. 2015. PMID: 25772995 Free PMC article.

2

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE. Chen H, et al. J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836. J Neurochem. 2016. PMID: 27580471 Free PMC article.

3

Mild metabolic perturbations alter succinylation of mitochondrial proteins.

Chen H, Xu H, Potash S, Starkov A, Belousov VV, Bilan DS, Denton TT, Gibson GE. Chen H, et al. J Neurosci Res. 2017 Nov;95(11):2244-2252. doi: 10.1002/jnr.24103. Epub 2017 Jun 20. J Neurosci Res. 2017. PMID: 28631845 Free PMC article.

4

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human-induced pluripotent stem cells, neural stem cells, and neurons.

Chen H, Cross AC, Thakkar A, Xu H, Li A, Paull D, Noggle SA, Kruger L, Denton TT, Gibson GE. Chen H, et al. J Neurochem. 2021 Mar;156(6):867-879. doi: 10.1111/jnc.15160. Epub 2020 Sep 12. J Neurochem. 2021. PMID: 32865230 Free article.

5

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease.

Sun L, Bhawal R, Xu H, Chen H, Anderson ET, Haroutunian V, Cross AC, Zhang S, Gibson GE. Sun L, et al. J Neurochem. 2021 Jul;158(2):282-296. doi: 10.1111/jnc.15377. Epub 2021 May 12. J Neurochem. 2021. PMID: 33905124 Free article.

6

Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability.

Shi Q, Karuppagounder SS, Xu H, Pechman D, Chen H, Gibson GE. Shi Q, et al. Neurochem Int. 2007 Jun;50(7-8):921-31. doi: 10.1016/j.neuint.2007.03.010. Epub 2007 Apr 7. Neurochem Int. 2007. PMID: 17482317 Free PMC article.

7

Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.

Huang HM, Ou HC, Xu H, Chen HL, Fowler C, Gibson GE. Huang HM, et al. Among authors: chen hl. J Neurosci Res. 2003 Oct 15;74(2):309-17. doi: 10.1002/jnr.10756. J Neurosci Res. 2003. PMID: 14515360

8

Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Shi Q, Chen HL, Xu H, Gibson GE. Shi Q, et al. Among authors: chen hl. J Biol Chem. 2005 Mar 25;280(12):10888-96. doi: 10.1074/jbc.M409064200. Epub 2005 Jan 12. J Biol Chem. 2005. PMID: 15649899 Free article.

9

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.

Gibson GE, Chen HL, Xu H, Qiu L, Xu Z, Denton TT, Shi Q. Gibson GE, et al. Among authors: chen hl. Neurobiol Aging. 2012 Jun;33(6):1121.e13-24. doi: 10.1016/j.neurobiolaging.2011.11.003. Epub 2011 Dec 14. Neurobiol Aging. 2012. PMID: 22169199 Free PMC article.

10

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease.

Banerjee K, Munshi S, Xu H, Frank DE, Chen HL, Chu CT, Yang J, Cho S, Kagan VE, Denton TT, Tyurina YY, Jiang JF, Gibson GE. Banerjee K, et al. Among authors: chen hl. Neurochem Int. 2016 Jun;96:32-45. doi: 10.1016/j.neuint.2016.02.011. Epub 2016 Feb 23. Neurochem Int. 2016. PMID: 26923918 Free PMC article.

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