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Taming the induced folding of drug-targeted kinases.
Fernández A, Bazán S, Chen J. Fernández A, et al. Among authors: chen j. Trends Pharmacol Sci. 2009 Feb;30(2):66-71. doi: 10.1016/j.tips.2008.11.001. Epub 2008 Dec 26. Trends Pharmacol Sci. 2009. PMID: 19097649
An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic.
Fernández A, Sanguino A, Peng Z, Ozturk E, Chen J, Crespo A, Wulf S, Shavrin A, Qin C, Ma J, Trent J, Lin Y, Han HD, Mangala LS, Bankson JA, Gelovani J, Samarel A, Bornmann W, Sood AK, Lopez-Berestein G. Fernández A, et al. Among authors: chen j. J Clin Invest. 2007 Dec;117(12):4044-54. doi: 10.1172/JCI32373. J Clin Invest. 2007. PMID: 18060038 Free PMC article.
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