Chen P - Search Results

1

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.

Blasina A, Hallin J, Chen E, Arango ME, Kraynov E, Register J, Grant S, Ninkovic S, Chen P, Nichols T, O'Connor P, Anderes K. Blasina A, et al. Among authors: chen p, chen e. Mol Cancer Ther. 2008 Aug;7(8):2394-404. doi: 10.1158/1535-7163.MCT-07-2391. Mol Cancer Ther. 2008. PMID: 18723486

2

Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors.

Teng M, Zhu J, Johnson MD, Chen P, Kornmann J, Chen E, Blasina A, Register J, Anderes K, Rogers C, Deng Y, Ninkovic S, Grant S, Hu Q, Lundgren K, Peng Z, Kania RS. Teng M, et al. Among authors: chen p, chen e. J Med Chem. 2007 Nov 1;50(22):5253-6. doi: 10.1021/jm0704604. Epub 2007 Sep 21. J Med Chem. 2007. PMID: 17887663

3

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.

Chen P, Lee NV, Hu W, Xu M, Ferre RA, Lam H, Bergqvist S, Solowiej J, Diehl W, He YA, Yu X, Nagata A, VanArsdale T, Murray BW. Chen P, et al. Mol Cancer Ther. 2016 Oct;15(10):2273-2281. doi: 10.1158/1535-7163.MCT-16-0300. Epub 2016 Aug 5. Mol Cancer Ther. 2016. PMID: 27496135

4

Pharmacological characterization of a small molecule inhibitor of c-Jun kinase.

Cho H, Black SC, Looper D, Shi M, Kelly-Sullivan D, Timofeevski S, Siegel K, Yu XH, McDonnell SR, Chen P, Yie J, Ogilvie KM, Fraser J, Briscoe CP. Cho H, et al. Among authors: chen p. Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1142-51. doi: 10.1152/ajpendo.90298.2008. Epub 2008 Aug 26. Am J Physiol Endocrinol Metab. 2008. PMID: 18728225 Free article.

5

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).

Cheng H, Orr STM, Bailey S, Brooun A, Chen P, Deal JG, Deng YL, Edwards MP, Gallego GM, Grodsky N, Huang B, Jalaie M, Kaiser S, Kania RS, Kephart SE, Lafontaine J, Ornelas MA, Pairish M, Planken S, Shen H, Sutton S, Zehnder L, Almaden CD, Bagrodia S, Falk MD, Gukasyan HJ, Ho C, Kang X, Kosa RE, Liu L, Spilker ME, Timofeevski S, Visswanathan R, Wang Z, Meng F, Ren S, Shao L, Xu F, Kath JC. Cheng H, et al. Among authors: chen p. J Med Chem. 2021 Jan 14;64(1):644-661. doi: 10.1021/acs.jmedchem.0c01652. Epub 2020 Dec 24. J Med Chem. 2021. PMID: 33356246

6

Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.

Humphries PS, Lafontaine JA, Agree CS, Alexander D, Chen P, Do QQ, Li LY, Lunney EA, Rajapakse RJ, Siegel K, Timofeevski SL, Wang T, Wilhite DM. Humphries PS, et al. Among authors: chen p. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2099-102. doi: 10.1016/j.bmcl.2009.03.023. Epub 2009 Mar 13. Bioorg Med Chem Lett. 2009. PMID: 19327989

7

Identification of small-molecule inhibitors of the JIP-JNK interaction.

Chen T, Kablaoui N, Little J, Timofeevski S, Tschantz WR, Chen P, Feng J, Charlton M, Stanton R, Bauer P. Chen T, et al. Among authors: chen p. Biochem J. 2009 May 13;420(2):283-94. doi: 10.1042/BJ20081899. Biochem J. 2009. PMID: 19243309

8

Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design.

Chen P, Deng YL, Bergqvist S, Falk MD, Liu W, Timofeevski S, Brooun A. Chen P, et al. Protein Sci. 2014 Oct;23(10):1332-40. doi: 10.1002/pro.2517. Epub 2014 Aug 7. Protein Sci. 2014. PMID: 25043846 Free PMC article.

9

Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery.

Johnson MC, Hu Q, Lingardo L, Ferre RA, Greasley S, Yan J, Kath J, Chen P, Ermolieff J, Alton G. Johnson MC, et al. Among authors: chen p. J Comput Aided Mol Des. 2011 Jul;25(7):689-98. doi: 10.1007/s10822-011-9456-7. Epub 2011 Jul 22. J Comput Aided Mol Des. 2011. PMID: 21779981

10

Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.

Shankaran K, Donnelly KL, Shah SK, Caldwell CG, Chen P, Hagmann WK, Maccoss M, Humes JL, Pacholok SG, Kelly TM, Grant SK, Wong KK. Shankaran K, et al. Among authors: chen p. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. doi: 10.1016/j.bmcl.2004.09.019. Bioorg Med Chem Lett. 2004. PMID: 15501067

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