Chen RZ - Search Results

1

The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.

Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS. Tizzano JP, et al. Among authors: chen rz. J Pharmacol Exp Ther. 2008 Mar;324(3):1111-26. doi: 10.1124/jpet.107.133132. Epub 2007 Dec 18. J Pharmacol Exp Ther. 2008. PMID: 18089843

2

Chronic administration of nalmefene leads to increased food intake and body weight gain in mice.

Chen RZ, Huang RR, Shen CP, MacNeil DJ, Fong TM. Chen RZ, et al. Eur J Pharmacol. 2004 Jul 8;495(1):63-6. doi: 10.1016/j.ejphar.2004.05.025. Eur J Pharmacol. 2004. PMID: 15219821

3

Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking mu-opioid receptors.

Chen RZ, Frassetto A, Fong TM. Chen RZ, et al. Brain Res. 2006 Sep 7;1108(1):176-8. doi: 10.1016/j.brainres.2006.06.006. Epub 2006 Jul 7. Brain Res. 2006. PMID: 16828068

4

The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist.

Zhang J, Frassetto A, Huang RR, Lao JZ, Pasternak A, Wang SP, Metzger JM, Strack AM, Fong TM, Chen RZ. Zhang J, et al. Among authors: chen rz. Eur J Pharmacol. 2006 Sep 18;545(2-3):147-52. doi: 10.1016/j.ejphar.2006.06.069. Epub 2006 Jul 5. Eur J Pharmacol. 2006. PMID: 16876155

5

Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.

Chen RZ, Frassetto A, Lao JZ, Huang RR, Xiao JC, Clements MJ, Walsh TF, Hale JJ, Wang J, Tong X, Fong TM. Chen RZ, et al. Eur J Pharmacol. 2008 Apr 28;584(2-3):338-42. doi: 10.1016/j.ejphar.2008.02.029. Epub 2008 Feb 19. Eur J Pharmacol. 2008. PMID: 18336811

6

Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor.

Frassetto A, Zhang J, Lao JZ, White A, Metzger JM, Fong TM, Chen RZ. Frassetto A, et al. Among authors: chen rz. Brain Res. 2008 Oct 21;1236:140-4. doi: 10.1016/j.brainres.2008.08.012. Epub 2008 Aug 15. Brain Res. 2008. PMID: 18755168

7

Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice.

Chen RZ, Huang RR, Shen CP, MacNeil DJ, Fong TM. Chen RZ, et al. Brain Res. 2004 Mar 5;999(2):227-30. doi: 10.1016/j.brainres.2003.12.004. Brain Res. 2004. PMID: 14759503

8

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.

Vachal P, Fletcher JM, Fong TM, Huang CC, Lao J, Xiao JC, Shen CP, Strack AM, Shearman L, Stribling S, Chen RZ, Frassetto A, Tong X, Wang J, Ball RG, Tsou NN, Hickey GJ, Thompson DF, Faidley TD, Nicolich S, Achanfuo-Yeboah J, Hora DF, Hale JJ, Hagmann WK. Vachal P, et al. Among authors: chen rz. J Med Chem. 2009 Apr 23;52(8):2550-8. doi: 10.1021/jm900063x. J Med Chem. 2009. PMID: 19320488

9

Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.

Yan L, Huo P, Debenham JS, Madsen-Duggan CB, Lao J, Chen RZ, Xiao JC, Shen CP, Stribling DS, Shearman LP, Strack AM, Tsou N, Ball RG, Wang J, Tong X, Bateman TJ, Reddy VB, Fong TM, Hale JJ. Yan L, et al. Among authors: chen rz. J Med Chem. 2010 May 27;53(10):4028-37. doi: 10.1021/jm100023j. J Med Chem. 2010. PMID: 20423086

10

Effects of mutations at conserved TM II residues on ligand binding and activation of mouse 5-HT6 receptor.

Zhang J, Shen CP, Xiao JC, Lanza TJ, Lin LS, Francis BE, Fong TM, Chen RZ. Zhang J, et al. Among authors: chen rz. Eur J Pharmacol. 2006 Mar 18;534(1-3):77-82. doi: 10.1016/j.ejphar.2006.01.049. Eur J Pharmacol. 2006. PMID: 16612839

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