Chen Z - Search Results

1

A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors.

Chen Z, Kwan SY, Mir A, Hazeltine M, Shin M, Liang SQ, Chan IL, Kelly K, Ghanta KS, Gaston N, Cao Y, Xie J, Gao G, Xue W, Sontheimer EJ, Watts JK. Chen Z, et al. CRISPR J. 2023 Dec;6(6):570-582. doi: 10.1089/crispr.2023.0048. CRISPR J. 2023. PMID: 38108517 Free PMC article.

2

5'-Modifications improve potency and efficacy of DNA donors for precision genome editing.

Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, Lawson ND, Rivera-Pérez JA, Sontheimer EJ, Watts JK, Mello CC. Ghanta KS, et al. Among authors: chen z. Elife. 2021 Oct 19;10:e72216. doi: 10.7554/eLife.72216. Elife. 2021. PMID: 34665130 Free PMC article.

3

Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo.

Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodríguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ. Ibraheim R, et al. Among authors: chen z. Nat Commun. 2021 Nov 1;12(1):6267. doi: 10.1038/s41467-021-26518-y. Nat Commun. 2021. PMID: 34725353 Free PMC article.

4

A split prime editor with untethered reverse transcriptase and circular RNA template.

Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodríguez TC, Liang SQ, Xue W, Sontheimer EJ. Liu B, et al. Among authors: chen z. Nat Biotechnol. 2022 Sep;40(9):1388-1393. doi: 10.1038/s41587-022-01255-9. Epub 2022 Apr 4. Nat Biotechnol. 2022. PMID: 35379962

5

Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing.

Chen Z, Devi G, Arif A, Zamore PD, Sontheimer EJ, Watts JK. Chen Z, et al. ACS Chem Biol. 2022 May 20;17(5):1045-1050. doi: 10.1021/acschembio.2c00116. Epub 2022 Apr 21. ACS Chem Biol. 2022. PMID: 35446558 Free PMC article.

6

Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.

Liang SQ, Liu P, Ponnienselvan K, Suresh S, Chen Z, Kramme C, Chatterjee P, Zhu LJ, Sontheimer EJ, Xue W, Wolfe SA. Liang SQ, et al. Among authors: chen z. Nat Methods. 2023 Jun;20(6):898-907. doi: 10.1038/s41592-023-01859-2. Epub 2023 May 8. Nat Methods. 2023. PMID: 37156841

7

Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates.

Liu B, Dong X, Zheng C, Keener D, Chen Z, Cheng H, Watts JK, Xue W, Sontheimer EJ. Liu B, et al. Among authors: chen z. Nat Biotechnol. 2023 Sep 14. doi: 10.1038/s41587-023-01947-w. Online ahead of print. Nat Biotechnol. 2023. PMID: 37709915

8

Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.

Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. Zhang H, et al. Among authors: chen z. Nucleic Acids Res. 2024 Jan 25;52(2):977-997. doi: 10.1093/nar/gkad1125. Nucleic Acids Res. 2024. PMID: 38033325 Free PMC article.

9

Longitudinal change of serum AIM2 levels after aneurysmal subarachnoid hemorrhage and its prognostic significance: a two-center prospective cohort study.

Chen Z, Zou S, Shan H, Liu J, Tian D, Wu X, Du Q, Dong X, Yang D. Chen Z, et al. Sci Rep. 2024 May 7;14(1):10430. doi: 10.1038/s41598-024-61185-1. Sci Rep. 2024. PMID: 38714826

10

Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives.

Huang S, Ma Q, Liao X, Yin X, Shen T, Liu X, Tang W, Wang Y, Wang L, Xin H, Li X, Chang L, Chen Z, Liu R, Wu C, Wang D, Guo G, Zhu F. Huang S, et al. Among authors: chen z. Sci Rep. 2024 May 7;14(1):10457. doi: 10.1038/s41598-024-61194-0. Sci Rep. 2024. PMID: 38714778

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