Chen ZJ - Search Results

1

Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.

Lee KM, Lin CC, Servetto A, Bae J, Kandagatla V, Ye D, Kim G, Sudhan DR, Mendiratta S, González Ericsson PI, Balko JM, Lee J, Barnes S, Malladi VS, Tabrizi S, Reddy SM, Yum S, Chang CW, Hutchinson KE, Yost SE, Yuan Y, Chen ZJ, Fu YX, Hanker AB, Arteaga CL. Lee KM, et al. Among authors: chen zj. Cancer Immunol Res. 2022 Jul 1;10(7):829-843. doi: 10.1158/2326-6066.CIR-21-0826. Cancer Immunol Res. 2022. PMID: 35561311 Free PMC article.

2

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR. Deng L, et al. Among authors: chen zj. Immunity. 2014 Nov 20;41(5):843-52. doi: 10.1016/j.immuni.2014.10.019. Epub 2014 Nov 6. Immunity. 2014. PMID: 25517616 Free PMC article.

3

cGAS is essential for the antitumor effect of immune checkpoint blockade.

Wang H, Hu S, Chen X, Shi H, Chen C, Sun L, Chen ZJ. Wang H, et al. Among authors: chen zj, chen c, chen x. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1637-1642. doi: 10.1073/pnas.1621363114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137885 Free PMC article.

4

A STING-activating nanovaccine for cancer immunotherapy.

Luo M, Wang H, Wang Z, Cai H, Lu Z, Li Y, Du M, Huang G, Wang C, Chen X, Porembka MR, Lea J, Frankel AE, Fu YX, Chen ZJ, Gao J. Luo M, et al. Among authors: chen zj, chen x. Nat Nanotechnol. 2017 Jul;12(7):648-654. doi: 10.1038/nnano.2017.52. Epub 2017 Apr 24. Nat Nanotechnol. 2017. PMID: 28436963 Free PMC article.

5

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.

Xu MM, Pu Y, Han D, Shi Y, Cao X, Liang H, Chen X, Li XD, Deng L, Chen ZJ, Weichselbaum RR, Fu YX. Xu MM, et al. Among authors: chen zj, chen x. Immunity. 2017 Aug 15;47(2):363-373.e5. doi: 10.1016/j.immuni.2017.07.016. Epub 2017 Aug 8. Immunity. 2017. PMID: 28801234 Free PMC article.

6

Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity.

Zhang F, Manna S, Pop LM, Chen ZJ, Fu YX, Hannan R. Zhang F, et al. Among authors: chen zj. Semin Radiat Oncol. 2020 Apr;30(2):129-138. doi: 10.1016/j.semradonc.2019.12.009. Semin Radiat Oncol. 2020. PMID: 32381292 Review.

7

Old dogs, new trick: classic cancer therapies activate cGAS.

Yum S, Li M, Chen ZJ. Yum S, et al. Among authors: chen zj. Cell Res. 2020 Aug;30(8):639-648. doi: 10.1038/s41422-020-0346-1. Epub 2020 Jun 15. Cell Res. 2020. PMID: 32541866 Free PMC article. Review.

8

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.

Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM. Guan J, et al. Among authors: chen zj, chen m, chen x. Cancer Cell. 2021 Jan 11;39(1):109-121.e5. doi: 10.1016/j.ccell.2020.11.004. Epub 2020 Dec 17. Cancer Cell. 2021. PMID: 33338427 Free PMC article.

9

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.

Yum S, Li M, Fang Y, Chen ZJ. Yum S, et al. Among authors: chen zj. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2100225118. doi: 10.1073/pnas.2100225118. Proc Natl Acad Sci U S A. 2021. PMID: 33785602 Free PMC article.

10

TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance.

Li T, Yum S, Li M, Chen X, Zuo X, Chen ZJ. Li T, et al. Among authors: chen zj, chen x. J Exp Med. 2022 Jan 3;219(1):e20211539. doi: 10.1084/jem.20211539. Epub 2021 Dec 13. J Exp Med. 2022. PMID: 34901991 Free PMC article.

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