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2015 7
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Conditional knockout of smooth muscle sodium calcium exchanger type-1 lowers blood pressure and attenuates Angiotensin II-salt hypertension.
Wang Y, Chen L, Li M, Cha H, Iwamoto T, Zhang J. Wang Y, et al. Physiol Rep. 2015 Jan 27;3(1):e12273. doi: 10.14814/phy2.12273. Print 2015 Jan 1. Physiol Rep. 2015. PMID: 25626872 Free PMC article.
Isolated, pressurized mesenteric small resistance arteries from SM-NCX1 KO mice, compared to control arteries, were characterized by the following: (1) ~90% reduced NCX1 protein expression; (2) impaired functional responses to (i) acute NCX inhibition by SEA0400 or SN-6, (ii) NCX …
Isolated, pressurized mesenteric small resistance arteries from SM-NCX1 KO mice, compared to control arteries, were characterized by the fol …
Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesity.
Ali MI, Chen X, Didion SP. Ali MI, et al. Physiol Rep. 2015 Dec;3(12):e12630. doi: 10.14814/phy2.12630. Physiol Rep. 2015. PMID: 26660551 Free PMC article.
Responses of carotid arteries were examined in wild-type (eNOS(+/+)) and heterozygous eNOS-deficient (eNOS(+/-)) treated with either vehicle (saline), N(G)-nitro-L-arginine (L-NNA, 100 mumol/L), an inhibitor of nitric oxide synthase, or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxali …
Responses of carotid arteries were examined in wild-type (eNOS(+/+)) and heterozygous eNOS-deficient (eNOS(+/-)) treated with either vehicle …
In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl-/-) mice.
Chen J, Kaiyala KJ, Lam J, Agrawal N, Nguyen L, Ogimoto K, Spencer D, Morton GJ, Schwartz MW, Dichek HL. Chen J, et al. Physiol Rep. 2015 Apr;3(4):e12365. doi: 10.14814/phy2.12365. Physiol Rep. 2015. PMID: 25862097 Free PMC article.
Our results demonstrate that (1) the catalytic function of HL is required to rescue the lean body weight phenotype of hl(-/-) mice; (2) this effect involves complementary changes in both sides of the energy balance equation; and (3) the bridging function alone is insuffici …
Our results demonstrate that (1) the catalytic function of HL is required to rescue the lean body weight phenotype of hl(-/-) mice; (2) this …
Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines.
Li XC, Shull GE, Miguel-Qin E, Chen F, Zhuo JL. Li XC, et al. Physiol Rep. 2015 Nov;3(11):e12605. doi: 10.14814/phy2.12605. Physiol Rep. 2015. PMID: 26564064 Free PMC article.
The role of Na(+/)H(+) exchanger 3 (NHE3) in the kidney in angiotensin II (ANG II)-induced hypertension remains unknown. ...These responses were associated with significantly elevated plasma ANG II and aldosterone levels, and marked upregulation in aquaporin 1, the Na(+)/H …
The role of Na(+/)H(+) exchanger 3 (NHE3) in the kidney in angiotensin II (ANG II)-induced hypertension remains unknown. ...These res …