Cheng L - Search Results

1

Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.

Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z. Zhao C, et al. Among authors: cheng l. Mol Cell. 2023 Sep 7;83(17):3171-3187.e7. doi: 10.1016/j.molcel.2023.07.030. Epub 2023 Aug 18. Mol Cell. 2023. PMID: 37597514

2

Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode.

Yan W, Cheng L, Wang W, Wu C, Yang X, Du X, Ma L, Qi S, Wei Y, Lu Z, Yang S, Shao Z. Yan W, et al. Among authors: cheng l. Nat Commun. 2020 Oct 20;11(1):5287. doi: 10.1038/s41467-020-19109-w. Nat Commun. 2020. PMID: 33082324 Free PMC article.

3

Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.

Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z. Yuan Y, et al. Among authors: cheng l. Cell Res. 2021 Dec;31(12):1263-1274. doi: 10.1038/s41422-021-00566-x. Epub 2021 Sep 15. Cell Res. 2021. PMID: 34526663 Free PMC article.

4

Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes.

Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z. Zhao C, et al. Among authors: cheng l. Cell Res. 2022 Feb;32(2):218-221. doi: 10.1038/s41422-021-00567-w. Epub 2021 Sep 20. Cell Res. 2022. PMID: 34545189 Free PMC article. No abstract available.

5

Lighting up cholecystokinin.

Cheng L, Shao Z. Cheng L, et al. Nat Chem Biol. 2021 Dec;17(12):1213-1214. doi: 10.1038/s41589-021-00857-9. Nat Chem Biol. 2021. PMID: 34556861 No abstract available.

6

Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.

Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S. Yang X, et al. Among authors: cheng l. Nat Chem Biol. 2022 Aug;18(8):831-840. doi: 10.1038/s41589-022-01038-y. Epub 2022 May 30. Nat Chem Biol. 2022. PMID: 35637350

7

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors.

Cheng L, Su L, Tian X, Xia F, Zhao C, Yan W, Shao Z. Cheng L, et al. J Vis Exp. 2022 Jun 8;(184). doi: 10.3791/64054. J Vis Exp. 2022. PMID: 35758708

8

Structure, function and drug discovery of GPCR signaling.

Cheng L, Xia F, Li Z, Shen C, Yang Z, Hou H, Sun S, Feng Y, Yong X, Tian X, Qin H, Yan W, Shao Z. Cheng L, et al. Mol Biomed. 2023 Dec 4;4(1):46. doi: 10.1186/s43556-023-00156-w. Mol Biomed. 2023. PMID: 38047990 Free PMC article. Review.

9

SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo.

Zhang S, Cao Z, Tian H, Shen G, Ma Y, Xie H, Liu Y, Zhao C, Deng S, Yang Y, Zheng R, Li W, Zhang N, Liu S, Wang W, Dai L, Shi S, Cheng L, Pan Y, Feng S, Zhao X, Deng H, Yang S, Wei Y. Zhang S, et al. Among authors: cheng l. Clin Cancer Res. 2011 Jul 1;17(13):4439-50. doi: 10.1158/1078-0432.CCR-10-3109. Epub 2011 May 27. Clin Cancer Res. 2011. PMID: 21622720

10

IL-35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells.

Wang Y, Mao Y, Zhang J, Shi G, Cheng L, Lin Y, Li Y, Zhang X, Zhang Y, Chen X, Deng J, Su X, Dai L, Yang Y, Zhang S, Yu D, Wei Y, Deng H. Wang Y, et al. Among authors: cheng l. J Cell Mol Med. 2018 Feb;22(2):1014-1025. doi: 10.1111/jcmm.13428. Epub 2017 Nov 29. J Cell Mol Med. 2018. PMID: 29193791 Free PMC article.

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