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Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers.
Kumar R, Coronel L, Somalanka B, Raju A, Aning OA, An O, Ho YS, Chen S, Mak SY, Hor PY, Yang H, Lakshmanan M, Itoh H, Tan SY, Lim YK, Wong APC, Chew SH, Huynh TH, Goh BC, Lim CY, Tergaonkar V, Cheok CF. Kumar R, et al. Among authors: cheok cf. Nat Commun. 2018 Sep 26;9(1):3931. doi: 10.1038/s41467-018-05805-1. Nat Commun. 2018. PMID: 30258081 Free PMC article.
Drugging in the absence of p53.
Aning OA, Cheok CF. Aning OA, et al. Among authors: cheok cf. J Mol Cell Biol. 2019 Mar 1;11(3):255-264. doi: 10.1093/jmcb/mjz012. J Mol Cell Biol. 2019. PMID: 30865230 Free PMC article. Review.
New insights into p53 based therapy.
Lane DP, Brown CJ, Verma C, Cheok CF. Lane DP, et al. Among authors: cheok cf. Discov Med. 2011 Aug;12(63):107-17. Discov Med. 2011. PMID: 21878188 Free article. Review.
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.
Kong LR, Ong RW, Tan TZ, Mohamed Salleh NAB, Thangavelu M, Chan JV, Koh LYJ, Periyasamy G, Lau JA, Le TBU, Wang L, Lee M, Kannan S, Verma CS, Lim CM, Chng WJ, Lane DP, Venkitaraman A, Hung HT, Cheok CF, Goh BC. Kong LR, et al. Among authors: cheok cf. Nat Commun. 2020 Apr 29;11(1):2086. doi: 10.1038/s41467-020-15608-y. Nat Commun. 2020. PMID: 32350249 Free PMC article.
Translating p53 into the clinic.
Cheok CF, Verma CS, Baselga J, Lane DP. Cheok CF, et al. Nat Rev Clin Oncol. 2011 Jan;8(1):25-37. doi: 10.1038/nrclinonc.2010.174. Epub 2010 Oct 26. Nat Rev Clin Oncol. 2011. PMID: 20975744 Review.
25 results