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Year Number of Results
2016 3
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2018 1
2020 1
2021 2
2023 2
2024 3

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14 results

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Chitinase-Like Protein Ym2 (Chil4) Regulates Regeneration of the Olfactory Epithelium via Interaction with Inflammation.
Wang L, Ren W, Li X, Zhang X, Tian H, Bhattarai JP, Challis RC, Lee AC, Zhao S, Yu H, Ma M, Yu Y. Wang L, et al. J Neurosci. 2021 Jun 30;41(26):5620-5637. doi: 10.1523/JNEUROSCI.1601-20.2021. Epub 2021 May 20. J Neurosci. 2021. PMID: 34016714 Free PMC article.
In this study, we elucidated a novel role of Ym2 (also known as Chil4 or Chi3l4), a chitinase-like protein expressed in supporting cells, in regulating regeneration of the injured OE in vivo in both male and female mice and cell proliferation/differentiation in OE colonies …
In this study, we elucidated a novel role of Ym2 (also known as Chil4 or Chi3l4), a chitinase-like protein expressed in supporting ce …
Targeted delivery of Chil3/Chil4 siRNA to alveolar macrophages using ternary complexes composed of HMG and oligoarginine micelles.
Choi M , Jeong H , Kim S , Kim M , Lee M , Rhim T . Choi M , et al. Nanoscale. 2020 Jan 2;12(2):933-943. doi: 10.1039/c9nr06382j. Nanoscale. 2020. PMID: 31840707
Cell-type-specific genes involved in disease can be effective therapeutic targets; therefore, the development of a cell-type-specific gene delivery system is essential. In this study, targeted delivery of Chil3 and Chil4 siRNA to activated macrophages was developed using a …
Cell-type-specific genes involved in disease can be effective therapeutic targets; therefore, the development of a cell-type-specific gene d …
Ym1 protein crystals promote type 2 immunity.
Heyndrickx I, Deswarte K, Verstraete K, Verschueren KHG, Smole U, Aegerter H, Dansercoer A, Hammad H, Savvides SN, Lambrecht BN. Heyndrickx I, et al. Elife. 2024 Jan 9;12:RP90676. doi: 10.7554/eLife.90676. Elife. 2024. PMID: 38194250 Free PMC article.
Although mice do not encode Gal10 in their genome, they do form pseudo-CLCs, made from the chitinase-like proteins Ym1 and/or Ym2, encoded by Chil3 and Chil4 and made by myeloid and epithelial cells respectively. Here, we investigated the biological effects of pseudo-CLCs …
Although mice do not encode Gal10 in their genome, they do form pseudo-CLCs, made from the chitinase-like proteins Ym1 and/or Ym2, encoded b …
Evaluation of chickens infected with a recombinant virulent NDV clone expressing chicken IL4.
Marcano VC, Susta L, Diel DG, Cardenas-Garcia S, Miller PJ, Afonso CL, Brown CC. Marcano VC, et al. Microb Pathog. 2021 Oct;159:105116. doi: 10.1016/j.micpath.2021.105116. Epub 2021 Jul 31. Microb Pathog. 2021. PMID: 34339794
To assess the role of chIL4 in velogenic NDV pathogenesis we created a vNDV infectious clone expressing chIL4. ...In addition, chIL4 signal was found in all tissues of rZJ1-IL4 birds at 5DPI. ...
To assess the role of chIL4 in velogenic NDV pathogenesis we created a vNDV infectious clone expressing chIL4. ...In addition, …
STAT6-induced production of mucus and resistin-like molecules in lung Club cells does not protect against helminth or influenza A virus infection.
Ruhl A, Antão AV, Dietschmann A, Radtke D, Tenbusch M, Voehringer D. Ruhl A, et al. Eur J Immunol. 2024 Jan;54(1):e2350558. doi: 10.1002/eji.202350558. Epub 2023 Oct 25. Eur J Immunol. 2024. PMID: 37855177
CCSP-Cre_STAT6vt mice and bronchiolar organoids derived from these show an enhanced expression of the chitinase-like protein Chil4 (Ym2) and resistin-like molecules (Relm-alpha, -beta, -gamma). ...
CCSP-Cre_STAT6vt mice and bronchiolar organoids derived from these show an enhanced expression of the chitinase-like protein Chil4 (Y …
A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation.
Ualiyeva S, Lemire E, Wong C, Perniss A, Boyd AA, Avilés EC, Minichetti DG, Maxfield A, Roditi R, Matsumoto I, Wang X, Deng W, Barrett NA, Buchheit KM, Laidlaw TM, Boyce JA, Bankova LG, Haber AL. Ualiyeva S, et al. Sci Immunol. 2024 Feb 2;9(92):eabq4341. doi: 10.1126/sciimmunol.abq4341. Epub 2024 Feb 2. Sci Immunol. 2024. PMID: 38306414
Inhalation of Alternaria induced mucosal epithelial effector molecules including Chil4 and a distinct pathway leading to proliferation of the quiescent olfactory horizontal basal stem cell (HBC) pool, both triggered in the absence of olfactory apoptosis. ...
Inhalation of Alternaria induced mucosal epithelial effector molecules including Chil4 and a distinct pathway leading to proliferatio …
Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice.
Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ong CB, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):331-40. doi: 10.1165/rcmb.2015-0165OC. Am J Respir Cell Mol Biol. 2016. PMID: 26203683
In contrast, 9-day ozone exposure elicited type 2 immune responses in C57BL/6 mice, with mucosal mRNA overexpression of Arg1, Ccl8 (MCP-2), Ccl11, Chil4 (Ym2), Clca1 (Gob5), Il5, Il10, and Il13; increased density of mucosal eosinophils; and nasal epithelial remodeling (e.g …
In contrast, 9-day ozone exposure elicited type 2 immune responses in C57BL/6 mice, with mucosal mRNA overexpression of Arg1, Ccl8 (MCP-2), …
Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer.
Lozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M. Lozano-Pope I, et al. BMC Cancer. 2017 Feb 15;17(1):133. doi: 10.1186/s12885-017-3114-y. BMC Cancer. 2017. PMID: 28201999 Free PMC article.
The most significant differentially upregulated gene during Helicobacter infection in Myd88 (-/-) mice was chitinase-like 4 (chil4), which is involved in tissue remodeling and wound healing. ...
The most significant differentially upregulated gene during Helicobacter infection in Myd88 (-/-) mice was chitinase-like 4 (chil4), …
14 results