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CHN1 promotes epithelial-mesenchymal transition via the Akt/GSK-3beta/Snail pathway in cervical carcinoma.
Zhao H, Wang L, Wang S, Chen X, Liang M, Zhang X, Wang J, Xu X. Zhao H, et al. J Transl Med. 2021 Jul 8;19(1):295. doi: 10.1186/s12967-021-02963-7. J Transl Med. 2021. PMID: 34238315 Free PMC article.
Upregulation and knockdown of CHN1 were achieved by transfection of CC cells. The effect of CHN1 on cell proliferation was determined by CCK-8 and plate clone formation assays. ...In contrast, silencing of CHN1 inhibited these phenomena. Overexpression of …
Upregulation and knockdown of CHN1 were achieved by transfection of CC cells. The effect of CHN1 on cell proliferation was det …
CHN1 is a Novel Prognostic Marker for Diffuse Large B-Cell Lymphoma.
Sun J, Zhu X, Zhao Y, Zhou Q, Qi R, Liu H. Sun J, et al. Pharmgenomics Pers Med. 2021 Apr 1;14:397-408. doi: 10.2147/PGPM.S301718. eCollection 2021. Pharmgenomics Pers Med. 2021. PMID: 33833551 Free PMC article.
RESULTS: We identified 6 candidate genes associated with the clinical outcome of DLBCL patients: CHN1, CD3D, CLU, ICOS, KLRB1 and LAT. Unlike the other five genes, CHN1 has not been previously reported to be implicated in lymphoma. ...Multivariate Cox regression ana …
RESULTS: We identified 6 candidate genes associated with the clinical outcome of DLBCL patients: CHN1, CD3D, CLU, ICOS, KLRB1 and LAT …
TBX18 knockdown sensitizes esophageal squamous cell carcinoma to radiotherapy by blocking the CHN1/RhoA axis.
Zhou J, Wu J, Wu G, Huang J, Zhang Y, Che J, Zhu K, Geng J, Fan Q. Zhou J, et al. Radiother Oncol. 2023 Sep;186:109788. doi: 10.1016/j.radonc.2023.109788. Epub 2023 Jul 1. Radiother Oncol. 2023. PMID: 37399907
Additionally, TBX18 was positively correlated with CHN1 in ESCC clinical specimens. Mechanistically, TBX18 bound to the CHN1 promoter region to transcriptionally activate CHN1, thus elevating RhoA activity. Moreover, TBX18 knockdown reduced ESCC cell prolifer …
Additionally, TBX18 was positively correlated with CHN1 in ESCC clinical specimens. Mechanistically, TBX18 bound to the CHN1 p …
CHN1 gene mutation analysis in patients with Duane retraction syndrome.
Biler ED, Ilim O, Onay H, Uretmen O. Biler ED, et al. J AAPOS. 2017 Dec;21(6):472-475.e2. doi: 10.1016/j.jaapos.2017.07.208. Epub 2017 Oct 13. J AAPOS. 2017. PMID: 29031989
PURPOSE: To investigate CHN1 (chimerin 1) gene mutations in patients with isolated nonsyndromic Duane syndrome and accompanying positive familial history, bilaterality, or various systemic disorders. ...Eleven cases had an additional congenital disorder. In 2 patients, 2 d …
PURPOSE: To investigate CHN1 (chimerin 1) gene mutations in patients with isolated nonsyndromic Duane syndrome and accompanying posit …
CHN1 and duane retraction syndrome: Expanding the phenotype to cranial nerves development disease.
Angelini C, Trimouille A, Arveiler B, Espil-Taris C, Ichinose N, Lasseaux E, Tourdias T, Lacombe D. Angelini C, et al. Eur J Med Genet. 2021 Apr;64(4):104188. doi: 10.1016/j.ejmg.2021.104188. Epub 2021 Mar 2. Eur J Med Genet. 2021. PMID: 33667650
A whole exome sequencing revealed a heterozygous missense variant in CHN1 gene. This gene encodes GTPase-activating protein and is involved in the assembly of neuronal locomotor circuits. ...We provide an additional description to support the role in cranial nerves develop …
A whole exome sequencing revealed a heterozygous missense variant in CHN1 gene. This gene encodes GTPase-activating protein and is in …
Bioinformatics-based analysis of the association between the A1-chimaerin (CHN1) gene and gastric cancer.
Li JP, Zeng SH, Zhang YH, Liu YJ. Li JP, et al. Bioengineered. 2021 Dec;12(1):2874-2889. doi: 10.1080/21655979.2021.1940621. Bioengineered. 2021. PMID: 34152250 Free PMC article.
Moreover, the CIBERSORT algorithm was used to estimate immune cell infiltration. In GC patients, CHN1 transcription and CHN1 protein expression were upregulated, and a high expression of CHN1 was remarkably linked to poor survival in GC patients. ...To our kn …
Moreover, the CIBERSORT algorithm was used to estimate immune cell infiltration. In GC patients, CHN1 transcription and CHN1 p …
Upregulation of miR-205 induces CHN1 expression, which is associated with the aggressive behaviour of cervical cancer cells and correlated with lymph node metastasis.
Liu J, Li Y, Chen X, Xu X, Zhao H, Wang S, Hao J, He B, Liu S, Wang J. Liu J, et al. BMC Cancer. 2020 Oct 27;20(1):1029. doi: 10.1186/s12885-020-07478-w. BMC Cancer. 2020. PMID: 33109127 Free PMC article.
The CHN1 gene was shown to be targeted by miR-205 in HeLa cells. Interestingly, transfection with miR-205 mimic upregulated CHN1 mRNA and protein, while miR-205 inhibitor downregulated CHN1 in high-risk and human papilloma virus (HPV)-negative human cervical …
The CHN1 gene was shown to be targeted by miR-205 in HeLa cells. Interestingly, transfection with miR-205 mimic upregulated CHN1 …
Identification of a novel CHN1 p.(Phe213Val) variant in a large Han Chinese family with congenital Duane retraction syndrome.
Zhou TC, Duan WH, Fu XL, Zhu Q, Guo LY, Zhou Y, Hua ZJ, Li XJ, Yang DM, Zhang JY, Yin J, Zhang XF, Zhou GL, Hu M. Zhou TC, et al. Sci Rep. 2020 Oct 1;10(1):16225. doi: 10.1038/s41598-020-73190-1. Sci Rep. 2020. PMID: 33004823 Free PMC article.
Ophthalmic and physical examinations, as well as genetic screenings for variants in chimerin 1 (CHN1), were performed for all family members. Functional analyses of a CHN1 variant in 293T cells included a Rac-GTP activation assay, alpha2-chimaerin translocation assa …
Ophthalmic and physical examinations, as well as genetic screenings for variants in chimerin 1 (CHN1), were performed for all family …
Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract.
McDonough LD, Mishra AA, Tosini N, Kakade P, Penumutchu S, Liang SH, Maufrais C, Zhai B, Taur Y, Belenky P, Bennett RJ, Hohl TM, Koh AY, Ene IV. McDonough LD, et al. mBio. 2021 Dec 21;12(6):e0287821. doi: 10.1128/mBio.02878-21. Epub 2021 Nov 2. mBio. 2021. PMID: 34724818 Free PMC article.
Despite its prevalence as a human commensal, the murine GI tract is generally refractory to colonization with the C. albicans reference isolate SC5314. Here, we identify two C. albicans isolates, 529L and CHN1, that stably colonize the murine GI tract in three different an …
Despite its prevalence as a human commensal, the murine GI tract is generally refractory to colonization with the C. albicans reference isol …
Duane Syndrome.
Barry BJ, Whitman MC, Hunter DG, Engle EC. Barry BJ, et al. 2007 May 25 [updated 2019 Aug 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2007 May 25 [updated 2019 Aug 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301369 Free Books & Documents. Review.
GENETIC COUNSELING: The majority of individuals with isolated Duane syndrome represent simplex cases (i.e., a single occurrence in a family), with a positive family history apparent for only approximately 10% of affected individuals. Duane syndrome resulting from a CHN1, M …
GENETIC COUNSELING: The majority of individuals with isolated Duane syndrome represent simplex cases (i.e., a single occurrence in a family) …
101 results