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Peripherally restricted CB1 receptor blockers.
Chorvat RJ. Chorvat RJ. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4751-60. doi: 10.1016/j.bmcl.2013.06.066. Epub 2013 Jul 4. Bioorg Med Chem Lett. 2013. PMID: 23902803 Review.
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.
Tam J, Cinar R, Liu J, Godlewski G, Wesley D, Jourdan T, Szanda G, Mukhopadhyay B, Chedester L, Liow JS, Innis RB, Cheng K, Rice KC, Deschamps JR, Chorvat RJ, McElroy JF, Kunos G. Tam J, et al. Among authors: chorvat rj. Cell Metab. 2012 Aug 8;16(2):167-79. doi: 10.1016/j.cmet.2012.07.002. Epub 2012 Jul 26. Cell Metab. 2012. PMID: 22841573 Free PMC article.
Preclinical toxicity evaluation of JD5037, a peripherally restricted CB1 receptor inverse agonist, in rats and dogs for treatment of nonalcoholic steatohepatitis.
Kale VP, Gibbs S, Taylor JA, Zmarowski A, Novak J, Patton K, Sparrow B, Gorospe J, Anand S, Cinar R, Kunos G, Chorvat RJ, Terse PS. Kale VP, et al. Among authors: chorvat rj. Regul Toxicol Pharmacol. 2019 Dec;109:104483. doi: 10.1016/j.yrtph.2019.104483. Epub 2019 Sep 30. Regul Toxicol Pharmacol. 2019. PMID: 31580887 Free PMC article.
Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines.
Chorvat RJ, Bakthavatchalam R, Beck JP, Gilligan PJ, Wilde RG, Cocuzza AJ, Hobbs FW, Cheeseman RS, Curry M, Rescinito JP, Krenitsky P, Chidester D, Yarem JA, Klaczkiewicz JD, Hodge CN, Aldrich PE, Wasserman ZR, Fernandez CH, Zaczek R, Fitzgerald LW, Huang SM, Shen HL, Wong YN, Chien BM, Arvanitis A, et al. Chorvat RJ, et al. J Med Chem. 1999 Mar 11;42(5):833-48. doi: 10.1021/jm980224g. J Med Chem. 1999. PMID: 10072681
Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines.
Arvanitis AG, Gilligan PJ, Chorvat RJ, Cheeseman RS, Christos TE, Bakthavatchalam R, Beck JP, Cocuzza AJ, Hobbs FW, Wilde RG, Arnold C, Chidester D, Curry M, He L, Hollis A, Klaczkiewicz J, Krenitsky PJ, Rescinito JP, Scholfield E, Culp S, De Souza EB, Fitzgerald L, Grigoriadis D, Tam SW, Shen HL, et al. Arvanitis AG, et al. Among authors: chorvat rj. J Med Chem. 1999 Mar 11;42(5):805-18. doi: 10.1021/jm980222w. J Med Chem. 1999. PMID: 10072679
18 results