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Targeting the pancreatic β-cell to treat diabetes.
Vetere A, Choudhary A, Burns SM, Wagner BK. Vetere A, et al. Among authors: choudhary a. Nat Rev Drug Discov. 2014 Apr;13(4):278-89. doi: 10.1038/nrd4231. Epub 2014 Feb 14. Nat Rev Drug Discov. 2014. PMID: 24525781 Review.
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dančík V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK. Chou DH, et al. Among authors: choudhary a. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. doi: 10.1021/jacs.5b04284. Epub 2015 Jun 15. J Am Chem Soc. 2015. PMID: 26042473 Free PMC article.
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, Clemons PA, Wagner BK, Choudhary A. Maji B, et al. Among authors: choudhary a. Cell. 2019 May 2;177(4):1067-1079.e19. doi: 10.1016/j.cell.2019.04.009. Cell. 2019. PMID: 31051099 Free PMC article.
Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells.
Lee M, Maji B, Manna D, Kahraman S, Elgamal RM, Small J, Kokkonda P, Vetere A, Goldberg JM, Lippard SJ, Kulkarni RN, Wagner BK, Choudhary A. Lee M, et al. Among authors: choudhary a. J Am Chem Soc. 2020 Apr 8;142(14):6477-6482. doi: 10.1021/jacs.0c00099. Epub 2020 Mar 16. J Am Chem Soc. 2020. PMID: 32175731 Free PMC article.
Phosphorylation-Inducing Chimeric Small Molecules.
Siriwardena SU, Munkanatta Godage DNP, Shoba VM, Lai S, Shi M, Wu P, Chaudhary SK, Schreiber SL, Choudhary A. Siriwardena SU, et al. Among authors: choudhary a. J Am Chem Soc. 2020 Aug 19;142(33):14052-14057. doi: 10.1021/jacs.0c05537. Epub 2020 Aug 4. J Am Chem Soc. 2020. PMID: 32787262
1,078 results